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Optimization and Simulation of Tandem Column Supercritical Fluid Chromatography Separations Using Column Back Pressure as a Unique Parameter

Analytical chemistry (Washington), 2014-04, Vol.86 (8), p.4033-4040

2014

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Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

Drug discovery today, 2014-01, Vol.19 (1), p.95-102

2014

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Fast Photochemical Oxidation of Proteins (FPOP) Maps the Epitope of EGFR Binding to Adnectin

Journal of the American Society for Mass Spectrometry, 2014-12, Vol.25 (12), p.2084-2092

2014

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Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis

Analytical chemistry (Washington), 2017-02, Vol.89 (4), p.2250-2258

2017

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Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL‑6 Receptor upon Binding of Protein Therapeutics

Analytical chemistry (Washington), 2017-07, Vol.89 (14), p.7742-7749

2017

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Approach To Evaluating Dried Blood Spot Sample Stability during Drying Process and Discovery of a Treated Card To Maintain Analyte Stability by Rapid On-Card pH Modification

Analytical chemistry (Washington), 2011-12, Vol.83 (23), p.9033-9038

2011

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The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton’s tyrosine kinase

Journal of Chromatography A, 2017-03, Vol.1487, p.116-128

2017

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Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry

Journal of the American Society for Mass Spectrometry, 2018-01, Vol.29 (1), p.174-182

2018

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Characterization and quantification of histidine degradation in therapeutic protein formulations by size exclusion-hydrophilic interaction two dimensional-liquid chromatography with stable-isotope labeling mass spectrometry

Journal of Chromatography A, 2015-12, Vol.1426, p.133-139

2015

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Structural mass spectrometry in biologics discovery: advances and future trends

Drug discovery today, 2012-12, Vol.17 (23-24), p.1323-1330

2012

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Challenges in accurate quantitation of lysophosphatidic acids in human biofluids

Journal of lipid research, 2014-08, Vol.55 (8), p.1784-1796

2014

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High-resolution MS for structural characterization of protein therapeutics: advances and future directions

Bioanalysis, 2013-05, Vol.5 (10), p.1299-1313

2013

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Characterization of disulfide linkages in recombinant human granulocyte-colony stimulating factor

Rapid communications in mass spectrometry, 2013-05, Vol.27 (9), p.940-946

2013

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A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies

Biomedical chromatography, 2012-08, Vol.26 (8), p.1024-1032

2012

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Utility of Ion Mobility Mass Spectrometry for Drug-to-Antibody Ratio Measurements in Antibody-Drug Conjugates

Journal of the American Society for Mass Spectrometry, 2015-10, Vol.26 (10), p.1791-1794

2015

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Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry

Journal of the American Society for Mass Spectrometry, 2017-05, Vol.28 (5), p.795-802

2017

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Enantioselective chromatography in drug discovery

Drug Discovery Today, 2005-04, Vol.10 (8), p.571-577

2005

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Chromatography-based methods for determining molar extinction coefficients of cytotoxic payload drugs and drug antibody ratios of antibody drug conjugates

Journal of Chromatography A, 2016-07, Vol.1455, p.133-139

2016

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Characterization of protein therapeutics by mass spectrometry: recent developments and future directions

Drug discovery today, 2011, Vol.16 (1), p.58-64

2011

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Development of a highly sensitive liquid chromatography/tandem mass spectrometry method to quantify total and free levels of a target protein, interferon-gamma-inducible protein-10, at picomolar levels in human serum

Rapid communications in mass spectrometry, 2014-07, Vol.28 (13), p.1535-1543

2014

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Pellet Digestion: A Simple And Efficient Sample Preparation Technique For Lc–MS/MS Quantification of Large Therapeutic Proteins in Plasma

Bioanalysis, 2012-01, Vol.4 (1), p.17-28

2012

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Metabolomics in the pharmaceutical industry

Drug discovery today. Technologies, 2015-06, Vol.13, p.25-31

2015

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Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development

Journal of organic chemistry, 2015-07, Vol.80 (14), p.7019-7032

2015

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Attribution of the discrepancy between ELISA and LC-MS/MS assay results of a PEGylated scaffold protein in post-dose monkey plasma samples due to the presence of anti-drug antibodies

Analytical and bioanalytical chemistry, 2012-01, Vol.402 (3), p.1229-1239

2012

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A Tris (2-Carboxyethyl) Phosphine (TCEP) Related Cleavage on Cysteine-Containing Proteins

Journal of the American Society for Mass Spectrometry, 2010-05, Vol.21 (5), p.837-844

2010

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Optimization and Simulation of Tandem Column Supercritical Fluid Chromatography Separations Using Column Back Pressure as a Unique Parameter

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

Fast Photochemical Oxidation of Proteins (FPOP) Maps the Epitope of EGFR Binding to Adnectin

Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis

Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL‑6 Receptor upon Binding of Protein Therapeutics

Approach To Evaluating Dried Blood Spot Sample Stability during Drying Process and Discovery of a Treated Card To Maintain Analyte Stability by Rapid On-Card pH Modification

The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton’s tyrosine kinase

Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry

Characterization and quantification of histidine degradation in therapeutic protein formulations by size exclusion-hydrophilic interaction two dimensional-liquid chromatography with stable-isotope labeling mass spectrometry

Structural mass spectrometry in biologics discovery: advances and future trends

Challenges in accurate quantitation of lysophosphatidic acids in human biofluids

High-resolution MS for structural characterization of protein therapeutics: advances and future directions

Characterization of disulfide linkages in recombinant human granulocyte-colony stimulating factor

A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies

Utility of Ion Mobility Mass Spectrometry for Drug-to-Antibody Ratio Measurements in Antibody-Drug Conjugates

Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry

Enantioselective chromatography in drug discovery

Chromatography-based methods for determining molar extinction coefficients of cytotoxic payload drugs and drug antibody ratios of antibody drug conjugates

Characterization of protein therapeutics by mass spectrometry: recent developments and future directions

Development of a highly sensitive liquid chromatography/tandem mass spectrometry method to quantify total and free levels of a target protein, interferon-gamma-inducible protein-10, at picomolar levels in human serum

Pellet Digestion: A Simple And Efficient Sample Preparation Technique For Lc–MS/MS Quantification of Large Therapeutic Proteins in Plasma

Metabolomics in the pharmaceutical industry

Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development

Attribution of the discrepancy between ELISA and LC-MS/MS assay results of a PEGylated scaffold protein in post-dose monkey plasma samples due to the presence of anti-drug antibodies

A Tris (2-Carboxyethyl) Phosphine (TCEP) Related Cleavage on Cysteine-Containing Proteins

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