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Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac

Drug metabolism and disposition, 2015-09, Vol.43 (9), p.1307-1315

2015

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Dabigatran Etexilate and Digoxin: Comparison as Clinical Probe Substrates for Evaluation of P‐gp Inhibition

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.788-792

2018

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Managing the challenge of chemically reactive metabolites in drug development

Nature reviews. Drug discovery, 2011-04, Vol.10 (4), p.292-306

2011

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The role of transporters in toxicity and disease

Drug metabolism and disposition, 2014-04, Vol.42 (4), p.541-545

2014

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Generating an in vitro-in vivo correlation for metabolism and liver enrichment of a hepatitis C virus drug, faldaprevir, using a rat hepatocyte model (HepatoPac)

Drug metabolism and disposition, 2014-03, Vol.42 (3), p.407-414

2014

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Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions

Drug metabolism and disposition, 2014-11, Vol.42 (11), p.1940-1946

2014

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Metabolic switching of BILR 355 in the presence of ritonavir. II. Uncovering novel contributions by gut bacteria and aldehyde oxidase

Drug metabolism and disposition, 2012-06, Vol.40 (6), p.1130-1137

2012

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Membrane transporters in drug development

Nature reviews. Drug discovery, 2010-03, Vol.9 (3), p.215-236

2010

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Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1206-1221

2019

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Metabolic switching of BILR 355 in the presence of ritonavir. I. Identifying an unexpected disproportionate human metabolite

Drug metabolism and disposition, 2012-06, Vol.40 (6), p.1122-1129

2012

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Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac

Drug metabolism and disposition, 2014-03, Vol.42 (3), p.394-406

2014

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Defining the Role of Gut Bacteria in the Metabolism of Deleobuvir: In Vitro and In Vivo Studies

Drug metabolism and disposition, 2015-10, Vol.43 (10), p.1612-1618

2015

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Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes

Drug metabolism and disposition, 2016-03, Vol.44 (3), p.466-475

2016

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Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation

Drug metabolism and disposition, 2014-03, Vol.42 (3), p.384-393

2014

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Enzyme kinetics in drug metabolism: fundamentals and applications

Methods in molecular biology (Clifton, N.J.), 2014, Vol.1113, p.1

2014

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Case study 7. Compiled aha moments in enzyme kinetics: authors' experiences

Methods in molecular biology (Clifton, N.J.), 2014, Vol.1113, p.513

Tweedie, Donald J

2014

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Case study 3. Application of basic enzyme kinetics to metabolism studies: real-life examples

Methods in molecular biology (Clifton, N.J.), 2014, Vol.1113, p.441

2014

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Expression and Characterization of Canine Cytochrome P450 2D15

Archives of biochemistry and biophysics, 1998-09, Vol.357 (1), p.27-36

1998

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Molecular Cloning, Expression, and Characterization of CYP2D17 from Cynomolgus Monkey Liver

Archives of biochemistry and biophysics, 1999-12, Vol.372 (1), p.189-196

1999

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Reversible mechanisms of enzyme inhibition and resulting clinical significance

Methods in molecular biology (Clifton, N.J.), 2014, Vol.1113, p.37

2014

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Induction of microsomal NADPH-cytochrome P-450 reductase and cytochrome P-450IVA1 (P-450LAω) by dehydroepiandrosterone in rats: a possible peroxisomal proliferator

Cancer research (Chicago, Ill.), 1989-05, Vol.49 (9), p.2337-2343

1989

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Sources of interindividual variability

Methods in molecular biology (Clifton, N.J.), 2014, Vol.1113, p.363

2014

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Fundamentals of enzyme kinetics

Methods in molecular biology (Clifton, N.J.), 2014, Vol.1113, p.9

2014

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Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine?

Drug metabolism and drug interactions, 2013-12, Vol.28 (4), p.239-246, Article 239

2013

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Rationalizing underprediction of drug clearance from enzyme and transporter kinetic data: from in vitro tools to mechanistic modeling

Methods in molecular biology (Clifton, N.J.), 2014, Vol.1113, p.255

Galetin, Aleksandra

2014

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Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac

Dabigatran Etexilate and Digoxin: Comparison as Clinical Probe Substrates for Evaluation of P‐gp Inhibition

Managing the challenge of chemically reactive metabolites in drug development

The role of transporters in toxicity and disease

Generating an in vitro-in vivo correlation for metabolism and liver enrichment of a hepatitis C virus drug, faldaprevir, using a rat hepatocyte model (HepatoPac)

Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions

Metabolic switching of BILR 355 in the presence of ritonavir. II. Uncovering novel contributions by gut bacteria and aldehyde oxidase

Membrane transporters in drug development

Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates

Metabolic switching of BILR 355 in the presence of ritonavir. I. Identifying an unexpected disproportionate human metabolite

Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac

Defining the Role of Gut Bacteria in the Metabolism of Deleobuvir: In Vitro and In Vivo Studies

Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes

Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation

Enzyme kinetics in drug metabolism: fundamentals and applications

Case study 7. Compiled aha moments in enzyme kinetics: authors' experiences

Case study 3. Application of basic enzyme kinetics to metabolism studies: real-life examples

Expression and Characterization of Canine Cytochrome P450 2D15

Molecular Cloning, Expression, and Characterization of CYP2D17 from Cynomolgus Monkey Liver

Reversible mechanisms of enzyme inhibition and resulting clinical significance

Induction of microsomal NADPH-cytochrome P-450 reductase and cytochrome P-450IVA1 (P-450LAω) by dehydroepiandrosterone in rats: a possible peroxisomal proliferator

Sources of interindividual variability

Fundamentals of enzyme kinetics

Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine?

Rationalizing underprediction of drug clearance from enzyme and transporter kinetic data: from in vitro tools to mechanistic modeling

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