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Synthesis, Structure−Activity Relationships, and Biological Properties of 1-Heteroaryl-4-[ω-(1H-indol-3-yl)alkyl]piperazines, Novel Potential Antipsychotics Combining Potent Dopamine D2 Receptor Antagonism with Potent Serotonin Reuptake Inhibition

Journal of medicinal chemistry, 2005-11, Vol.48 (22), p.6855-6869

2005

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SLV310, a novel, potential antipsychotic, combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (3), p.405-408

2003

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Structure-Affinity Relationship Studies on 5-HT1A receptor Ligands. 2. Heterobicyclic Phenylpiperazines with N4-Aralkyl Substituents

Journal of medicinal chemistry, 1994-08, Vol.37 (17), p.2761-2773

1994

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A Series of N4-Imidoethyl Derivatives of 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazine as 5-HT1A Receptor Ligands: Synthesis and Structure-Affinity Relationships

Journal of medicinal chemistry, 1995-10, Vol.38 (21), p.4303-4308

1995

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The concept of selectivity in 5-HT receptor research

European journal of pharmacology, 1990-06, Vol.188 (6), p.301-312

1990

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N4-Unsubstituted N1-Arylpiperazines as High-Affinity 5-HT1A Receptor Ligands

Journal of medicinal chemistry, 1995-05, Vol.38 (11), p.1942-1954

1995

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Preclinical pharmacology of flesinoxan: A potential anxiolytic and antidepressant drug

Human psychopharmacology, 1991-10, Vol.6 (S1), p.S53-S61

1991

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Serotonergic receptors in anxiety and aggression; evidence from animal pharmacology

Human psychopharmacology, 1991-10, Vol.6 (S1), p.S73-S78

1991

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Evaluation of the receptor selectivity of the H3 receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5‐HT3 receptor revealed

British journal of pharmacology, 1995-10, Vol.116 (4), p.2315-2321

1995

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5-HT1A- versus D2-Receptor Selectivity of Flesinoxan and Analogous N 4-Substituted N 1-Arylpiperazines

Journal of medicinal chemistry, 1997-01, Vol.40 (3), p.300-312

1997

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Synthesis and structure–Activity data of some new epibatidine analogues

Bioorganic & medicinal chemistry, 1998-11, Vol.6 (11), p.2103-2110

1998

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Metabolism of chlorodiphenyl ethers and Irgasan DP 300

Xenobiotica, 1979-01, Vol.9 (2), p.65-77

1979

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Synthesis, Structure−Activity Relationships, and Biological Properties of 1-Heteroaryl-4-[ω-(1 H -indol-3-yl)alkyl]piperazines, Novel Potential Antipsychotics Combining Potent Dopamine D 2 Receptor Antagonism with Potent Serotonin Reuptake Inhibition

Journal of medicinal chemistry, 2005-11, Vol.48 (22), p.6855-6869

2005

Volltextzugriff (PDF)

Structure-affinity relationship studies on 5-HT1A receptor ligands. 1. Heterobicyclic phenylpiperazines with N4-alkyl substituents

Journal of medicinal chemistry, 1993-09, Vol.36 (19), p.2751-2760

1993

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Identification of hydroxyhalobiphenyls as their methyl ethers by gas chromatography mass spectrometry

Biological Mass Spectrometry, 1977-10, Vol.4 (5), p.310-316

1977

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Serotonin agonists and antagonists. Pharmacological tools and therapeutics

Recueil des Travaux Chimiques des Pays-Bas, 1993, Vol.112 (2), p.126-130

1993

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New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D2-Receptor and serotonin 5-HT1A-Receptor affinities

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2345-2349

2001

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Reductive dechlorination of chlorobiphenylols by rats

Experientia, 1977-09, Vol.33 (9), p.1134-1136

1977

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Ethopharmacological studies differentiate the effects of various serotonergic compounds on aggression in rats

European journal of pharmacology, 1990-07, Vol.183 (4), p.1384-1384

1990

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Some thoughts on aqueous solubilities and partition coefficients of PCB, and the mathematical correlation between bioaccumulation and physico-chemical properties

Chemosphere (Oxford), 1978, Vol.7 (10), p.849-860

1978

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Adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-HT1A receptor agonist flesinoxan

European journal of pharmacology, 1994-04, Vol.256 (2), p.141-147

1994

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2-Phenylpyrroles as conformationally restricted benzamide analogs. A new class of potential antipsychotics. 2

Journal of medicinal chemistry, 1988-10, Vol.31 (10), p.1934-1940

1988

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Identification of hydroxylated chlorodibenzo-p-dioxins, chlorodibenzofurans, chlorodiphenyl ethers and chloronaphthalenes as their methyl ethers by gas chromatography mass spectrometry

Biological Mass Spectrometry, 1978-03, Vol.5 (3), p.224-231

1978

Volltextzugriff (PDF)

Ligand binding assays

Pharmacochemistry Library, 1997, Vol.27, p.67-71

1997

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Serenics: pharmacology and metabolism

European journal of pharmacology, 1990-07, Vol.183 (4), p.1402-1402

1990

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Synthesis, Structure−Activity Relationships, and Biological Properties of 1-Heteroaryl-4-[ω-(1H-indol-3-yl)alkyl]piperazines, Novel Potential Antipsychotics Combining Potent Dopamine D2 Receptor Antagonism with Potent Serotonin Reuptake Inhibition

SLV310, a novel, potential antipsychotic, combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition

Structure-Affinity Relationship Studies on 5-HT1A receptor Ligands. 2. Heterobicyclic Phenylpiperazines with N4-Aralkyl Substituents

A Series of N4-Imidoethyl Derivatives of 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazine as 5-HT1A Receptor Ligands: Synthesis and Structure-Affinity Relationships

The concept of selectivity in 5-HT receptor research

N4-Unsubstituted N1-Arylpiperazines as High-Affinity 5-HT1A Receptor Ligands

Preclinical pharmacology of flesinoxan: A potential anxiolytic and antidepressant drug

Serotonergic receptors in anxiety and aggression; evidence from animal pharmacology

Evaluation of the receptor selectivity of the H3 receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5‐HT3 receptor revealed

5-HT1A- versus D2-Receptor Selectivity of Flesinoxan and Analogous N 4-Substituted N 1-Arylpiperazines

Synthesis and structure–Activity data of some new epibatidine analogues

Metabolism of chlorodiphenyl ethers and Irgasan DP 300

Synthesis, Structure−Activity Relationships, and Biological Properties of 1-Heteroaryl-4-[ω-(1 H -indol-3-yl)alkyl]piperazines, Novel Potential Antipsychotics Combining Potent Dopamine D 2 Receptor Antagonism with Potent Serotonin Reuptake Inhibition

Structure-affinity relationship studies on 5-HT1A receptor ligands. 1. Heterobicyclic phenylpiperazines with N4-alkyl substituents

Identification of hydroxyhalobiphenyls as their methyl ethers by gas chromatography mass spectrometry

Serotonin agonists and antagonists. Pharmacological tools and therapeutics

New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D2-Receptor and serotonin 5-HT1A-Receptor affinities

Reductive dechlorination of chlorobiphenylols by rats

Ethopharmacological studies differentiate the effects of various serotonergic compounds on aggression in rats

Some thoughts on aqueous solubilities and partition coefficients of PCB, and the mathematical correlation between bioaccumulation and physico-chemical properties

Adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-HT1A receptor agonist flesinoxan

2-Phenylpyrroles as conformationally restricted benzamide analogs. A new class of potential antipsychotics. 2

Identification of hydroxylated chlorodibenzo-p-dioxins, chlorodibenzofurans, chlorodiphenyl ethers and chloronaphthalenes as their methyl ethers by gas chromatography mass spectrometry

Ligand binding assays

Serenics: pharmacology and metabolism

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