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The trypanosome alternative oxidase: a potential drug target?

Parasitology, 2018-02, Vol.145 (2), p.175-183

2018

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Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6

Cell reports (Cambridge), 2024-02, Vol.43 (2), p.113679-113679, Article 113679

2024

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RES-Seq-a barcoded library of drug-resistant Leishmania donovani allowing rapid assessment of cross-resistance and relative fitness

mBio, 2023-12, Vol.14 (6), p.e0180323

2023

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Direct and indirect approaches to identify drug modes of action

IUBMB life, 2018-01, Vol.70 (1), p.9-22

2018

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Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues

PLoS neglected tropical diseases, 2017-09, Vol.11 (9), p.e0005886-e0005886

2017

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Simplifying nature: Towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins

Bioorganic & medicinal chemistry, 2017-11, Vol.25 (22), p.6126-6136

2017

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One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Journal of medicinal chemistry, 2009-07, Vol.52 (14), p.4454-4465

2009

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Regulation of the cardiac Na(+) pump by palmitoylation of its catalytic and regulatory subunits

Biochemical Society transactions, 2013-02, Vol.41 (1), p.95

2013

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Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series

Microorganisms (Basel), 2021-06, Vol.9 (7), p.1408

2021

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Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1

PLoS pathogens, 2024-07, Vol.20 (7), p.e1012382

2024

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Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease

Antimicrobial agents and chemotherapy, 2022-01, Vol.66 (1), p.e0153521-e0153521

2022

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Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation

Critical reviews in biochemistry and molecular biology, 2018-03, Vol.53 (2), p.175-191

2018

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Regulation of the cardiac sodium pump

Cellular and molecular life sciences : CMLS, 2013-04, Vol.70 (8), p.1357-1380

2013

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Sulphate Removal Induces a Major Conformational Change in Leishmania mexicana Pyruvate Kinase in the Crystalline State

Journal of molecular biology, 2008-11, Vol.383 (3), p.615-626

2008

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RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin

Human molecular genetics, 2005-05, Vol.14 (9), p.1183-1197

2005

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The Inhibitory Effect of Phospholemman on the Sodium Pump Requires Its Palmitoylation

The Journal of biological chemistry, 2011-10, Vol.286 (41), p.36020-36031

2011

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Structure‐Based Design, Synthesis and Biological Evaluation of Bis‐Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase

European journal of organic chemistry, 2019-09, Vol.2019 (31-32), p.5434-5440

2019

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Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

Journal of medicinal chemistry, 2010-01, Vol.53 (1), p.221-229

2010

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A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle

The Journal of biological chemistry, 2013-05, Vol.288 (19), p.13808-13820

2013

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Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors

ChemMedChem, 2016-07, Vol.11 (14), p.1503-1506

2016

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Non-natural Acetogenin Analogues as Potent Trypanosoma brucei Inhibitors

ChemMedChem, 2014-11, Vol.9 (11), p.2548-2556

2014

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Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate

Molecular microbiology, 2006-09, Vol.61 (6), p.1457-1468

2006

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Diversity oriented syntheses of fused pyrimidines designed as potential antifolates

Organic & biomolecular chemistry, 2009-01, Vol.7 (9), p.1829-1842

2009

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Design and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors

ACS infectious diseases, 2018-04, Vol.4 (4), p.560-567

2018

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Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis

Bioorganic & medicinal chemistry, 2008-05, Vol.16 (9), p.5050-5061

2008

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The trypanosome alternative oxidase: a potential drug target?

Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6

RES-Seq-a barcoded library of drug-resistant Leishmania donovani allowing rapid assessment of cross-resistance and relative fitness

Direct and indirect approaches to identify drug modes of action

Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues

Simplifying nature: Towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Regulation of the cardiac Na(+) pump by palmitoylation of its catalytic and regulatory subunits

Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series

Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease

Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation

Regulation of the cardiac sodium pump

Sulphate Removal Induces a Major Conformational Change in Leishmania mexicana Pyruvate Kinase in the Crystalline State

RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin

The Inhibitory Effect of Phospholemman on the Sodium Pump Requires Its Palmitoylation

Structure‐Based Design, Synthesis and Biological Evaluation of Bis‐Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle

Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors

Non-natural Acetogenin Analogues as Potent Trypanosoma brucei Inhibitors

Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate

Diversity oriented syntheses of fused pyrimidines designed as potential antifolates

Design and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors

Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis

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