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Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9

Human molecular genetics, 2015-07, Vol.24 (13), p.3764-3774

2015

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Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos

Scientific reports, 2017-02, Vol.7 (1), p.42081-42081, Article 42081

2017

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CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys

Cell research, 2019-04, Vol.29 (4), p.334-336

2019

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CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms

Human molecular genetics, 2019-02, Vol.28 (4), p.561-571

2019

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CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases

Molecular neurodegeneration, 2015-08, Vol.10 (1), p.35, Article 35

2015

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PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis

Protein & cell, 2022-01, Vol.13 (1), p.26-46

2022

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Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates

Translational psychiatry, 2019-10, Vol.9 (1), p.267-13, Article 267

2019

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Application of CRISPR/Cas9 System in Establishing Large Animal Models

Frontiers in cell and developmental biology, 2022-05, Vol.10, p.919155-919155

2022

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A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Advanced science, 2023-11, Vol.10 (31), p.e2301120-e2301120

2023

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Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys

Signal transduction and targeted therapy, 2023-09, Vol.8 (1), p.358-358, Article 358

2023

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Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

Signal transduction and targeted therapy, 2023-09, Vol.8 (1), p.327-327, Article 327

2023

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Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig

Frontiers in cell and developmental biology, 2023-01, Vol.10, p.1115348-1115348

2023

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CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate

Cell discovery, 2023-03, Vol.9 (1), p.27-27, Article 27

2023

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A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington’s Disease

Cell, 2018-05, Vol.173 (4), p.989-1002.e13

2018

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Use of CRISPR/Cas9 to model brain diseases

Progress in neuro-psychopharmacology & biological psychiatry, 2018-02, Vol.81, p.488-492

2018

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Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate

Cell research, 2017-10, Vol.27 (10), p.1293-1297

2017

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TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS

Human molecular genetics, 2021-07, Vol.30 (16), p.1484-1496

2021

Volltextzugriff (PDF)

Large animal models for Huntington's disease research

Zoological research, 2024-03, Vol.45 (2), p.275

2024

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Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta

Alzheimer's & dementia, 2024-07

2024

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Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain

The Journal of neuroscience, 2015-05, Vol.35 (21), p.8345-8358

2015

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CRISPR: Established Editor of Human Embryos?

Cell stem cell, 2017-09, Vol.21 (3), p.295-296

2017

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CRISPR/Cas9: Implications for Modeling and Therapy of Neurodegenerative Diseases

Frontiers in molecular neuroscience, 2016-04, Vol.9, p.30-30

2016

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Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease

Nature biomedical engineering, 2023-05, Vol.7 (5), p.629

2023

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A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023)

Advanced science, 2023-11, Vol.10 (31)

2023

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Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin

Human molecular genetics, 2015-03, Vol.24 (5), p.1350-1362

2015

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Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9

Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos

CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys

CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms

CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases

PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis

Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates

Application of CRISPR/Cas9 System in Establishing Large Animal Models

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys

Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig

CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate

A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington’s Disease

Use of CRISPR/Cas9 to model brain diseases

Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate

TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS

Large animal models for Huntington's disease research

Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta

Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain

CRISPR: Established Editor of Human Embryos?

CRISPR/Cas9: Implications for Modeling and Therapy of Neurodegenerative Diseases

Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023)

Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin

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