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Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal

Cancer science, 2003-01, Vol.94 (1), p.15-21

2003

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Modulation of Akt Kinase Activity by Binding to Hsp90

Proceedings of the National Academy of Sciences - PNAS, 2000-09, Vol.97 (20), p.10832-10837

2000

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Dofequidar fumarate sensitizes cancer stem‐like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP‐mediated drug export

Cancer science, 2009-11, Vol.100 (11), p.2060-2068

2009

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Involvement of mitochondrial aggregation in arsenic trioxide (As2O3)‐induced apoptosis in human glioblastoma cells

Cancer science, 2005-11, Vol.96 (11), p.825-833

2005

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Acyl‐CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide

Cancer science, 2009-08, Vol.100 (8), p.1556-1562

2009

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Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

Cancer research (Chicago, Ill.), 2009-05, Vol.69 (10), p.4225-4234

2009

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Akt/Protein Kinase B-Dependent Phosphorylation and Inactivation of WEE1Hu Promote Cell Cycle Progression at G2/M Transition

Molecular and Cellular Biology, 2005-07, Vol.25 (13), p.5725-5737

2005

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Platelet aggregation in the formation of tumor metastasis

Proceedings of the Japan Academy, Series B, 2008/06/30, Vol.84(6), pp.189-198

2008

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Small Molecules Destabilize cIAP1 by Activating Auto-ubiquitylation

The Journal of biological chemistry, 2008-04, Vol.283 (14), p.8961-8968

2008

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The Platelet Aggregation-Inducing Factor Aggrus/Podoplanin Promotes Pulmonary Metastasis

The American journal of pathology, 2007-04, Vol.170 (4), p.1337-1347

2007

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Dephosphorylated hypoxia-inducible factor 1α as a mediator of p53-dependent apoptosis during hypoxia

Oncogene, 2001-09, Vol.20 (41), p.5779-5788

2001

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Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

The Journal of biological chemistry, 2003-12, Vol.278 (49), p.49254-49260

2003

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Freud-1/Aki1, a Novel PDK1-Interacting Protein, Functions as a Scaffold To Activate the PDK1/Akt Pathway in Epidermal Growth Factor Signaling

Molecular and Cellular Biology, 2008-10, Vol.28 (19), p.5996-6009

2008

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Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions

Cancer science, 2010-05, Vol.101 (5), p.1125-1132

2010

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Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine)

Oncogene, 2002-03, Vol.21 (11), p.1727-1738

2002

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Rap1 Translates Chemokine Signals to Integrin Activation, Cell Polarization, and Motility across Vascular Endothelium under Flow

The Journal of cell biology, 2003-04, Vol.161 (2), p.417-427

2003

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Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis

Oncogene, 2003-08, Vol.22 (36), p.5579-5585

2003

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TRF1 Mediates Mitotic Abnormalities Induced by Aurora-A Overexpression

Cancer research (Chicago, Ill.), 2010-03, Vol.70 (5), p.2041-2052

2010

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A Synthetic Inhibitor of Histone Deacetylase, MS-27-275, with Marked in vivo Antitumor Activity against Human Tumors

Proceedings of the National Academy of Sciences - PNAS, 1999-04, Vol.96 (8), p.4592-4597

1999

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Breast Cancer Resistance Protein Exports Sulfated Estrogens but Not Free Estrogens

Molecular pharmacology, 2003-09, Vol.64 (3), p.610-618

2003

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Involvement of 3-Phosphoinositide-dependent Protein Kinase-1 in the MEK/MAPK Signal Transduction Pathway

The Journal of biological chemistry, 2004-08, Vol.279 (32), p.33759-33767

2004

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Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors

Oncogene, 2004-11, Vol.23 (52), p.8552-8556

2004

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Involvement of Hsp90 in Signaling and Stability of 3-Phosphoinositide-dependent Kinase-1

The Journal of biological chemistry, 2002-03, Vol.277 (12), p.10346-10353

2002

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Defects of the apoptotic pathway as therapeutic target against cancer

Drug resistance updates, 2005-12, Vol.8 (6), p.339-343

2005

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Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function

Nature cell biology, 2004-09, Vol.6 (9), p.849-860

2004

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Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal

Modulation of Akt Kinase Activity by Binding to Hsp90

Dofequidar fumarate sensitizes cancer stem‐like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP‐mediated drug export

Involvement of mitochondrial aggregation in arsenic trioxide (As2O3)‐induced apoptosis in human glioblastoma cells

Acyl‐CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide

Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

Akt/Protein Kinase B-Dependent Phosphorylation and Inactivation of WEE1Hu Promote Cell Cycle Progression at G2/M Transition

Platelet aggregation in the formation of tumor metastasis

Small Molecules Destabilize cIAP1 by Activating Auto-ubiquitylation

The Platelet Aggregation-Inducing Factor Aggrus/Podoplanin Promotes Pulmonary Metastasis

Dephosphorylated hypoxia-inducible factor 1α as a mediator of p53-dependent apoptosis during hypoxia

Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

Freud-1/Aki1, a Novel PDK1-Interacting Protein, Functions as a Scaffold To Activate the PDK1/Akt Pathway in Epidermal Growth Factor Signaling

Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine)

Rap1 Translates Chemokine Signals to Integrin Activation, Cell Polarization, and Motility across Vascular Endothelium under Flow

Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis

TRF1 Mediates Mitotic Abnormalities Induced by Aurora-A Overexpression

A Synthetic Inhibitor of Histone Deacetylase, MS-27-275, with Marked in vivo Antitumor Activity against Human Tumors

Breast Cancer Resistance Protein Exports Sulfated Estrogens but Not Free Estrogens

Involvement of 3-Phosphoinositide-dependent Protein Kinase-1 in the MEK/MAPK Signal Transduction Pathway

Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors

Involvement of Hsp90 in Signaling and Stability of 3-Phosphoinositide-dependent Kinase-1

Defects of the apoptotic pathway as therapeutic target against cancer

Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function

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