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Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition

Cell metabolism, 2021-04, Vol.33 (4), p.818-832.e7

2021

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The menthol receptor TRPM8 is the principal detector of environmental cold

Nature, 2007-07, Vol.448 (7150), p.204-208

2007

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TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents

Cell, 2006-03, Vol.124 (6), p.1269-1282

2006

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Coiled Coils Direct Assembly of a Cold-Activated TRP Channel

Neuron (Cambridge, Mass.), 2006-07, Vol.51 (2), p.201-212

2006

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The star-nosed mole reveals clues to the molecular basis of mammalian touch

PloS one, 2013-01, Vol.8 (1), p.e55001-e55001

2013

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Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model

PloS one, 2013-09, Vol.8 (9), p.e74891

2013

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Prediction of human serotonin and norepinephrine transporter occupancy of duloxetine by pharmacokinetic/pharmacodynamic modeling in the rat

The Journal of pharmacology and experimental therapeutics, 2012-04, Vol.341 (1), p.137

2012

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Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

Nature neuroscience, 2008-07, Vol.11 (7), p.772-779

2008

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Influence of ligand binding kinetics on functional inhibition of human recombinant serotonin and norepinephrine transporters

Journal of pharmacological and toxicological methods, 2010-03, Vol.61 (2), p.192-204

2010

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Neuroanatomical Evidence for Segregation of Nerve Fibers Conveying Light Touch and Pain Sensation in Eimer's Organ of the Mole

Proceedings of the National Academy of Sciences - PNAS, 2006-06, Vol.103 (24), p.9339-9344

2006

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Discovery of Axelopran (TD-1211): A Peripherally Restricted μ‑Opioid Receptor Antagonist

ACS medicinal chemistry letters, 2019-12, Vol.10 (12), p.1641-1647

2019

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Fine structure of Eimer's organ in the coast mole (Scapanus orarius)

Anatomical record (Hoboken, N.J. : 2007), 2007-05, Vol.290 (5), p.437-448

2007

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The in vitro pharmacological profile of TD-1211, a neutral opioid receptor antagonist

Naunyn-Schmiedeberg's archives of pharmacology, 2013-06, Vol.386 (6), p.479-491

2013

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The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity

Naunyn-Schmiedeberg's archives of pharmacology, 2013-06, Vol.386 (6), p.471-478

2013

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5-HT 4 receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment

Neuropharmacology, 2011-07, Vol.61 (1), p.69-79

2011

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Cer1p Functions as a Molecular Chaperone in the Endoplasmic Reticulum of Saccharomyces cerevisiae

Molecular and Cellular Biology, 1999-08, Vol.19 (8), p.5298-5307

1999

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Differential effects of monoamine reuptake inhibitors on food intake and energy expenditure in a mouse model of diet‐induced obesity

The FASEB journal, 2010-04, Vol.24 (S1), p.994.6-994.6

2010

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5-HT sub(4 receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment)

Neuropharmacology, 2011-08, Vol.61 (1-2), p.69-79

2011

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The Pharmacology of TD-8954, a Potent and Selective 5-HT4 Receptor Agonist with Gastrointestinal Prokinetic Properties

Frontiers in pharmacology, 2011-01, Vol.2

2011

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5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment

Neuropharmacology, 2011-07, Vol.61 (1-2), p.69-79

2011

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The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties

Frontiers in pharmacology, 2011, Vol.2, p.25-25

2011

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Modulation of Postendocytic Sorting of G Protein-Coupled Receptors

Science (American Association for the Advancement of Science), 2002-07, Vol.297 (5581), p.615-620

2002

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Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition

The menthol receptor TRPM8 is the principal detector of environmental cold

TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents

Coiled Coils Direct Assembly of a Cold-Activated TRP Channel

The star-nosed mole reveals clues to the molecular basis of mammalian touch

Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model

Prediction of human serotonin and norepinephrine transporter occupancy of duloxetine by pharmacokinetic/pharmacodynamic modeling in the rat

Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

Influence of ligand binding kinetics on functional inhibition of human recombinant serotonin and norepinephrine transporters

Neuroanatomical Evidence for Segregation of Nerve Fibers Conveying Light Touch and Pain Sensation in Eimer's Organ of the Mole

Discovery of Axelopran (TD-1211): A Peripherally Restricted μ‑Opioid Receptor Antagonist

Fine structure of Eimer's organ in the coast mole (Scapanus orarius)

The in vitro pharmacological profile of TD-1211, a neutral opioid receptor antagonist

The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity

5-HT 4 receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment

Cer1p Functions as a Molecular Chaperone in the Endoplasmic Reticulum of Saccharomyces cerevisiae

Differential effects of monoamine reuptake inhibitors on food intake and energy expenditure in a mouse model of diet‐induced obesity

5-HT sub(4 receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment)

The Pharmacology of TD-8954, a Potent and Selective 5-HT4 Receptor Agonist with Gastrointestinal Prokinetic Properties

5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment

The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties

Modulation of Postendocytic Sorting of G Protein-Coupled Receptors

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