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Osteoclast differentiation by RANKL and OPG signaling pathways

Journal of bone and mineral metabolism, 2021-01, Vol.39 (1), p.19-26

2021

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Siglec-15, a member of the sialic acid-binding lectin, is a novel regulator for osteoclast differentiation

Biochemical and biophysical research communications, 2011-06, Vol.409 (3), p.424-429

2011

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Siglec-15-targeting therapy protects against glucocorticoid-induced osteoporosis of growing skeleton in juvenile rats

Bone (New York, N.Y.), 2020-06, Vol.135, p.115331-115331, Article 115331

2020

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Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines

Bioorganic & medicinal chemistry letters, 2020-10, Vol.30 (20), p.127475-127475, Article 127475

2020

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Siglec-15-targeting therapy increases bone mass in rats without impairing skeletal growth

Bone (New York, N.Y.), 2018-11, Vol.116, p.172-180

2018

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Characterization, pharmacokinetics, and pharmacodynamics of anti-Siglec-15 antibody and its potency for treating osteoporosis and as follow-up treatment after parathyroid hormone use

Bone (New York, N.Y.), 2022-02, Vol.155, p.116241-116241, Article 116241

2022

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Impaired osteoclast differentiation and function and mild osteopetrosis development in Siglec-15-deficient mice

Bone (New York, N.Y.), 2013-03, Vol.53 (1), p.87-93

2013

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Structure and Function of Potential Glycosylation Sites of Dynactin-Associated Protein dynAP

Molecular biotechnology, 2022-06, Vol.64 (6), p.611-620

2022

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Osteoclast Differentiation Factor is a Ligand for Osteoprotegerin/Osteoclastogenesis-Inhibitory Factor and is Identical to TRANCE/RANKL

Proceedings of the National Academy of Sciences - PNAS, 1998-03, Vol.95 (7), p.3597-3602

1998

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Severe Osteoporosis in Mice Lacking Osteoclastogenesis Inhibitory Factor/Osteoprotegerin

Biochemical and biophysical research communications, 1998-06, Vol.247 (3), p.610-615

1998

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Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis

Journal of bone and mineral metabolism, 2002-01, Vol.20 (6), p.337-344

2002

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Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG)

Journal of bone and mineral metabolism, 2005, Vol.23 (1), p.41-47

2005

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Characterization of Structural Domains of Human Osteoclastogenesis Inhibitory Factor

The Journal of biological chemistry, 1998-02, Vol.273 (9), p.5117-5123

1998

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SNF4435C and D, Novel Immunosuppressants Produced by a Strain of Streptomyces spectabilis: I. Taxonomy, Fermentation, Isolation and Biological Activities

The Journal of Antibiotics, 2001/07/25, Vol.54(7), pp.541-547

2001

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Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation

Bone (New York, N.Y.), 2021-11, Vol.152, p.116095-116095, Article 116095

2021

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Interactions between Cancer and Bone Marrow Cells Induce Osteoclast Differentiation Factor Expression and Osteoclast-like Cell Formation in Vitro

Biochemical and biophysical research communications, 2000-01, Vol.267 (2), p.632-637

2000

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Osteoclastogenesis Inhibitory Factor (OCIF) Directly Inhibits Bone-Resorbing Activity of Isolated Mature Osteoclasts

Biochemical and biophysical research communications, 1998-10, Vol.251 (3), p.796-801

1998

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SNF4435C and d, novel immunosuppressants produced by a strain of Streptomyces spectabilis. II. Structure elucidation

Journal of antibiotics, 2001-07, Vol.54 (7), p.548-553

2001

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Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating β-Thalassemia and Sickle Cell Disease

ACS medicinal chemistry letters, 2021-01, Vol.12 (1), p.121-128

2021

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SW-163C and E, Novel Antitumor Depsipeptides Produced by Streptomyces sp: II. Structure Elucidation

The Journal of Antibiotics, 2001/08/25, Vol.54(8), pp.622-627

2001

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Characterization of Monomeric and Homodimeric Forms of Osteoclastogenesis Inhibitory Factor

Biochemical and biophysical research communications, 1998-04, Vol.245 (2), p.382-387

1998

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Reversal of Multidrug Resistance by Novel Nitrophenyl Pyrones, SNF4435C and D

Cancer science, 2001-11, Vol.92 (11), p.1235-1241

2001

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SW-163C and E, novel antitumor depsipeptides produced by Streptomyces sp. : I. Taxonomy, fermentation, isolation and biological activities

Journal of antibiotics, 2001-08, Vol.54 (8), p.615-627

2001

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Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor/osteoprotegerin : reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor

Journal of bone and mineral metabolism, 2001-01, Vol.19 (6), p.365-372

2001

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Immunological Study on Circulating Murine Osteoprotegerin/Osteoclastogenesis Inhibitory Factor (OPG/OCIF): Possible Role of OPG/OCIF in the Prevention of Osteoporosis in Pregnancy

Biochemical and biophysical research communications, 2001-10, Vol.288 (1), p.217-224

2001

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Osteoclast differentiation by RANKL and OPG signaling pathways

Siglec-15, a member of the sialic acid-binding lectin, is a novel regulator for osteoclast differentiation

Siglec-15-targeting therapy protects against glucocorticoid-induced osteoporosis of growing skeleton in juvenile rats

Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines

Siglec-15-targeting therapy increases bone mass in rats without impairing skeletal growth

Characterization, pharmacokinetics, and pharmacodynamics of anti-Siglec-15 antibody and its potency for treating osteoporosis and as follow-up treatment after parathyroid hormone use

Impaired osteoclast differentiation and function and mild osteopetrosis development in Siglec-15-deficient mice

Structure and Function of Potential Glycosylation Sites of Dynactin-Associated Protein dynAP

Osteoclast Differentiation Factor is a Ligand for Osteoprotegerin/Osteoclastogenesis-Inhibitory Factor and is Identical to TRANCE/RANKL

Severe Osteoporosis in Mice Lacking Osteoclastogenesis Inhibitory Factor/Osteoprotegerin

Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis

Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG)

Characterization of Structural Domains of Human Osteoclastogenesis Inhibitory Factor

SNF4435C and D, Novel Immunosuppressants Produced by a Strain of Streptomyces spectabilis: I. Taxonomy, Fermentation, Isolation and Biological Activities

Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation

Interactions between Cancer and Bone Marrow Cells Induce Osteoclast Differentiation Factor Expression and Osteoclast-like Cell Formation in Vitro

Osteoclastogenesis Inhibitory Factor (OCIF) Directly Inhibits Bone-Resorbing Activity of Isolated Mature Osteoclasts

SNF4435C and d, novel immunosuppressants produced by a strain of Streptomyces spectabilis. II. Structure elucidation

Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating β-Thalassemia and Sickle Cell Disease

SW-163C and E, Novel Antitumor Depsipeptides Produced by Streptomyces sp: II. Structure Elucidation

Characterization of Monomeric and Homodimeric Forms of Osteoclastogenesis Inhibitory Factor

Reversal of Multidrug Resistance by Novel Nitrophenyl Pyrones, SNF4435C and D

SW-163C and E, novel antitumor depsipeptides produced by Streptomyces sp. : I. Taxonomy, fermentation, isolation and biological activities

Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor/osteoprotegerin : reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor

Immunological Study on Circulating Murine Osteoprotegerin/Osteoclastogenesis Inhibitory Factor (OPG/OCIF): Possible Role of OPG/OCIF in the Prevention of Osteoporosis in Pregnancy

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