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Advances in epigenetics in systemic sclerosis: molecular mechanisms and therapeutic potential

Nature reviews. Rheumatology, 2021-10, Vol.17 (10), p.596-607

2021

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Dissecting the Cellular Mechanism of Prostacyclin Analog Iloprost in Reversing Vascular Dysfunction in Scleroderma

Arthritis & rheumatology (Hoboken, N.J.), 2021-03, Vol.73 (3), p.520-529

2021

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EZH2 Modulates the DNA Methylome and Controls T Cell Adhesion Through Junctional Adhesion Molecule A in Lupus Patients

Arthritis & rheumatology (Hoboken, N.J.), 2018-01, Vol.70 (1), p.98-108

2018

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Glycoprotein nonmetastatic melanoma protein B: A key mediator and an emerging therapeutic target in autoimmune diseases

The FASEB journal, 2020-07, Vol.34 (7), p.8810-8823

2020

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Unfolding the pathogenesis of scleroderma through genomics and epigenomics

Journal of autoimmunity, 2017-09, Vol.83, p.73-94

2017

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Identification of Cysteine‐Rich Angiogenic Inducer 61 as a Potential Antifibrotic and Proangiogenic Mediator in Scleroderma

Arthritis & rheumatology (Hoboken, N.J.), 2019-08, Vol.71 (8), p.1350-1359

2019

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Inhibition of EZH2 Ameliorates Lupus‐Like Disease in MRL/lpr Mice

Arthritis & rheumatology (Hoboken, N.J.), 2019-10, Vol.71 (10), p.1681-1690

2019

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Genome‐Wide Reduction in Chromatin Accessibility and Unique Transcription Factor Footprints in Endothelial Cells and Fibroblasts in Scleroderma Skin

Arthritis & rheumatology (Hoboken, N.J.), 2021-08, Vol.73 (8), p.1501-1513

2021

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Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors

Arthritis & rheumatology (Hoboken, N.J.), 2016-12, Vol.68 (12), p.2975-2985

2016

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Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa

Annals of the rheumatic diseases, 2018-11, Vol.77 (11), p.1653-1664

2018

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Hypomethylation of STAT1 and HLA-DRB1 is associated with type-I interferon-dependent HLA-DRB1 expression in lupus CD8+ T cells

Annals of the rheumatic diseases, 2019-04, Vol.78 (4), p.519-528

2019

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Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription

American Journal of Physiology: Cell Physiology, 2014-07, Vol.307 (1), p.C2-C13

2014

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Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury

The Journal of pharmacology and experimental therapeutics, 2014-06, Vol.349 (3), p.480-486

2014

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A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers

Arthritis research & therapy, 2019-09, Vol.21 (1), p.202-202, Article 202

2019

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Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis

Nature communications, 2022-11, Vol.13 (1), p.7074-7074, Article 7074

2022

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Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways

International journal of molecular sciences, 2024-02, Vol.25 (5), p.2454

2024

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Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis

Nature communications, 2024-01, Vol.15 (1), p.210-17, Article 210

2024

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A unique role for galectin-9 in angiogenesis and inflammatory arthritis

Arthritis research & therapy, 2018-02, Vol.20 (1), p.31-31, Article 31

2018

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Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs

Nature communications, 2022-10, Vol.13 (1), p.6358-6358, Article 6358

2022

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Role of cellular senescence in the pathogenesis of systemic sclerosis

Current opinion in rheumatology, 2022-11, Vol.34 (6), p.343-350

2022

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Functional Characterization of Glycoprotein Nonmetastatic Melanoma Protein B in Scleroderma Fibrosis

Frontiers in immunology, 2022-02, Vol.13, p.814533-814533

2022

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Effect of oxidative stress on protein tyrosine phosphatase 1B in scleroderma dermal fibroblasts

Arthritis & rheumatology (Hoboken, N.J.), 2012-06, Vol.64 (6), p.1978-1989

2012

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Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies

Annals of the rheumatic diseases, 2015-08, Vol.74 (8), p.1612-1620

2015

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Methyl-CpG-binding protein 2 mediates antifibrotic effects in scleroderma fibroblasts

Annals of the rheumatic diseases, 2018-08, p.annrheumdis-2018-213022

2018

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Activation of the Thromboxane A2 Receptor by 8-Isoprostane Inhibits the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Scleroderma

Journal of investigative dermatology, 2015-12, Vol.135 (12), p.3153-3162

2015

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Advances in epigenetics in systemic sclerosis: molecular mechanisms and therapeutic potential

Dissecting the Cellular Mechanism of Prostacyclin Analog Iloprost in Reversing Vascular Dysfunction in Scleroderma

EZH2 Modulates the DNA Methylome and Controls T Cell Adhesion Through Junctional Adhesion Molecule A in Lupus Patients

Glycoprotein nonmetastatic melanoma protein B: A key mediator and an emerging therapeutic target in autoimmune diseases

Unfolding the pathogenesis of scleroderma through genomics and epigenomics

Identification of Cysteine‐Rich Angiogenic Inducer 61 as a Potential Antifibrotic and Proangiogenic Mediator in Scleroderma

Inhibition of EZH2 Ameliorates Lupus‐Like Disease in MRL/lpr Mice

Genome‐Wide Reduction in Chromatin Accessibility and Unique Transcription Factor Footprints in Endothelial Cells and Fibroblasts in Scleroderma Skin

Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors

Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa

Hypomethylation of STAT1 and HLA-DRB1 is associated with type-I interferon-dependent HLA-DRB1 expression in lupus CD8+ T cells

Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription

Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers

Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis

Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways

Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis

A unique role for galectin-9 in angiogenesis and inflammatory arthritis

Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs

Role of cellular senescence in the pathogenesis of systemic sclerosis

Functional Characterization of Glycoprotein Nonmetastatic Melanoma Protein B in Scleroderma Fibrosis

Effect of oxidative stress on protein tyrosine phosphatase 1B in scleroderma dermal fibroblasts

Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies

Methyl-CpG-binding protein 2 mediates antifibrotic effects in scleroderma fibroblasts

Activation of the Thromboxane A2 Receptor by 8-Isoprostane Inhibits the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Scleroderma

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