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Delayed KCNQ1/KCNE1 assembly on the cell surface helps IKs fulfil its function as a repolarization reserve in the heart

The Journal of physiology, 2021-07, Vol.599 (13), p.3337-3361

2021

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Cellular mechanism of premature ventricular contraction–induced cardiomyopathy

Heart rhythm, 2014-11, Vol.11 (11), p.2064-2072

2014

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JPH-2 interacts with Cai -handling proteins and ion channels in dyads: Contribution to premature ventricular contraction–induced cardiomyopathy

Heart rhythm, 2016-03, Vol.13 (3), p.743-752

2016

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In aging hearts β-adrenergic stimulation can lead to a decrease, instead of an increase, in the slow delayed rectifier current: A new risk factor for aging-related arrhythmia?

Heart rhythm, 2021-12, Vol.18 (12), p.2210-2211

Tseng, Gea-Ny

2021

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Structure-function relationship of the slow delayed rectifier channel: impactful questions in 2020 and beyond

American journal of physiology. Heart and circulatory physiology, 2020-02, Vol.318 (2), p.H329-H331

Tseng, Gea-Ny

2020

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Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)

Molecular pharmacology, 2008-06, Vol.73 (6), p.1709-1721

2008

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Persistent PKA activation redistributes NaV1.5 to the cell surface of adult rat ventricular myocytes

The Journal of general physiology, 2024-02, Vol.156 (2)

2024

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Can biologic pacemakers respond to physiologic emotional arousal?

Heart rhythm, 2010-12, Vol.7 (12), p.1841-1842

Tseng, Gea-Ny, PhD

2010

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Gating charges in the activation and inactivation processes of the HERG channel

The Journal of general physiology, 2004-12, Vol.124 (6), p.703-718

2004

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Dynamic Partnership between KCNQ1 and KCNE1 and Influence on Cardiac IKs Current Amplitude by KCNE2

The Journal of biological chemistry, 2009-06, Vol.284 (24), p.16452-16462

2009

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Short-term memory in the heart: A road map for channel trafficking required

Heart rhythm, 2012-11, Vol.9 (11), p.1873-1874

Tseng, Gea-Ny, PhD, FAHA

2012

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Structural basis for KV7.1–KCNEx interactions in the IKs channel complex

Heart rhythm, 2010-05, Vol.7 (5), p.708-713

2010

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Delayed KCNQ1/KCNE1 assembly on the cell surface helps I Ks fulfil its function as a repolarization reserve in the heart

The Journal of physiology, 2021-07, Vol.599 (13), p.3337-3361

2021

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S-Palmitoylation of junctophilin-2 is critical for its role in tethering the sarcoplasmic reticulum to the plasma membrane

The Journal of biological chemistry, 2019-09, Vol.294 (36), p.13487-13501

2019

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A ligand-based virtual screening approach to identify small molecules as HERG channel activators

Combinatorial chemistry & high throughput screening, 2015-01, Vol.18 (3), p.269

2015

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Probing Binding Sites and Mechanisms of Action of an IKs Activator by Computations and Experiments

Biophysical journal, 2015-01, Vol.108 (1), p.62-75

2015

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Gating-Related Molecular Motions in the Extracellular Domain of the IKs Channel: Implications for IKs Channelopathy

The Journal of membrane biology, 2011-02, Vol.239 (3), p.137-156

2011

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Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart

Journal of molecular and cellular cardiology, 2021-06, Vol.155, p.1-9

2021

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Structural and functional role of the extracellular s5-p linker in the HERG potassium channel

The Journal of general physiology, 2002-11, Vol.120 (5), p.723-737

2002

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IKr: The hERG Channel

Journal of molecular and cellular cardiology, 2001-05, Vol.33 (5), p.835-849

Tseng, Gea-Ny

2001

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Dynamic palmitoylation regulates trafficking of K channel interacting protein 2 (KChIP2) across multiple subcellular compartments in cardiac myocytes

Journal of molecular and cellular cardiology, 2019-10, Vol.135, p.1-9

2019

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The phenotype of a KCNQ1 mutation depends on its KCNE partners: Is the cardiac slow delayed rectifier (IKs ) channel more than a KCNQ1/KCNE1 complex?

Heart rhythm, 2007-12, Vol.4 (12), p.1542-1543

Tseng, Gea-Ny, PhD

2007

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Building KCNQ1/KCNE1 Channel Models and Probing their Interactions by Molecular-Dynamics Simulations

Biophysical journal, 2013-12, Vol.105 (11), p.2461-2473

2013

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Dynamic conformational changes of extracellular S5–P linkers in the hERG channel

The Journal of physiology, 2005-11, Vol.569 (1), p.75-89

2005

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Chronic in vivo angiotensin II administration differentially modulates the slow delayed rectifier channels in atrial and ventricular myocytes

Heart rhythm, 2019-01, Vol.16 (1), p.108-116

2019

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Delayed KCNQ1/KCNE1 assembly on the cell surface helps IKs fulfil its function as a repolarization reserve in the heart

Cellular mechanism of premature ventricular contraction–induced cardiomyopathy

JPH-2 interacts with Cai -handling proteins and ion channels in dyads: Contribution to premature ventricular contraction–induced cardiomyopathy

In aging hearts β-adrenergic stimulation can lead to a decrease, instead of an increase, in the slow delayed rectifier current: A new risk factor for aging-related arrhythmia?

Structure-function relationship of the slow delayed rectifier channel: impactful questions in 2020 and beyond

Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)

Persistent PKA activation redistributes NaV1.5 to the cell surface of adult rat ventricular myocytes

Can biologic pacemakers respond to physiologic emotional arousal?

Gating charges in the activation and inactivation processes of the HERG channel

Dynamic Partnership between KCNQ1 and KCNE1 and Influence on Cardiac IKs Current Amplitude by KCNE2

Short-term memory in the heart: A road map for channel trafficking required

Structural basis for KV7.1–KCNEx interactions in the IKs channel complex

Delayed KCNQ1/KCNE1 assembly on the cell surface helps I Ks fulfil its function as a repolarization reserve in the heart

S-Palmitoylation of junctophilin-2 is critical for its role in tethering the sarcoplasmic reticulum to the plasma membrane

A ligand-based virtual screening approach to identify small molecules as HERG channel activators

Probing Binding Sites and Mechanisms of Action of an IKs Activator by Computations and Experiments

Gating-Related Molecular Motions in the Extracellular Domain of the IKs Channel: Implications for IKs Channelopathy

Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart

Structural and functional role of the extracellular s5-p linker in the HERG potassium channel

IKr: The hERG Channel

Dynamic palmitoylation regulates trafficking of K channel interacting protein 2 (KChIP2) across multiple subcellular compartments in cardiac myocytes

The phenotype of a KCNQ1 mutation depends on its KCNE partners: Is the cardiac slow delayed rectifier (IKs ) channel more than a KCNQ1/KCNE1 complex?

Building KCNQ1/KCNE1 Channel Models and Probing their Interactions by Molecular-Dynamics Simulations

Dynamic conformational changes of extracellular S5–P linkers in the hERG channel

Chronic in vivo angiotensin II administration differentially modulates the slow delayed rectifier channels in atrial and ventricular myocytes

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