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Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity

Bioorganic & medicinal chemistry, 2006-08, Vol.14 (15), p.5357-5369

2006

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Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (23), p.5344-5352

2005

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Can the calculation of ligand binding free energies be improved with continuum solvent electrostatics and an ideal‐gas entropy correction?

Journal of computational chemistry, 2002-09, Vol.23 (12), p.1143-1149

2002

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Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.817-822

2005

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Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors

Journal of medicinal chemistry, 1994-11, Vol.37 (23), p.3889-3901

1994

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Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function

Thrombosis and haemostasis, 1997-09, Vol.78 (3), p.1142

1997

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Active site-blocked factors VIIa and IXa differentially inhibit fibrin formation in a human ex vivo thrombosis model

Arteriosclerosis, thrombosis, and vascular biology, 1995-08, Vol.15 (8), p.1098

1995

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Activated clotting time as a appropriate test to compare heparin and direct thrombin inhibitors such as hirudin or Ro 46-6240 in experimental arterial thrombosis

Circulation (New York, N.Y.), 1995-03, Vol.91 (5), p.1568-1574

1995

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Endothelial cells stimulated with tumor necrosis factor-alpha express varying amounts of tissue factor resulting in inhomogenous fibrin deposition in a native blood flow system. Effects of thrombin inhibitors

The Journal of clinical investigation, 1994-05, Vol.93 (5), p.2073-2083

1994

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Role of Collagen-Adherent Platelets in Mediating Fibrin Formation in Flowing Whole Blood

Blood, 1995-11, Vol.86 (10), p.3815-3822

1995

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Relationship between tissue factor expression and deposition of fibrin, platelets, and leukocytes on cultured endothelial cells under venous blood flow conditions

Blood, 1993-04, Vol.81 (8), p.2050-2058

1993

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Activated clotting time as an appropriate test to compare heparin and direct thrombin inhibitor such as hirudin or Ro 46-6240 in experimental arterial thrombosis

Circulation (New York, N.Y.), 1995-03, Vol.91 (5), p.1568

1995

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Identification of a sulfated tetrasaccharide with heparin-like antiproliferative activity

Bioorganic & medicinal chemistry letters, 1994-06, Vol.4 (12), p.1419-1422

1994

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The heparin-like antiproliferative activity of sulfated tetrasaccharides is sensitive to structural variation

Bioorganic & medicinal chemistry letters, 1995-03, Vol.5 (5), p.437-442

1995

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Heparin, carboxyl-reduced sulfated heparin, and Trestatin A sulfate. Antiproliferative and anticoagulant activities

Carbohydrate research, 1990-09, Vol.204, p.131-139

1990

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The Development of Potent and Highly Selective Thrombin Inhibitors

European journal of medicinal chemistry, 1995, Vol.30, p.131s-138s

1995

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Platelet adhesion, release and aggregation in flowing blood: effects of surface properties and platelet function

Thrombosis and haemostasis, 1976-01, Vol.35 (1), p.124

1976

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Synthesis of an N-Acetylated Heparin Pentasaccharide and its anticoagulant activity in comparison with the heparin pentasaccharide with high anti-factor-Xa activity

Helvetica chimica acta, 1989-09, Vol.72 (6), p.1268-1277

1989

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Decreased adhesion of giant (Bernard-Soulier) platelets to subendothelium: Further implications on the role of the von Willebrand factor in hemostasis

The American journal of medicine, 1974-01, Vol.57 (6), p.920-926

1974

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Hereditary Defect in Platelet Function in Rats

Blood, 1972-08, Vol.40 (2), p.217-226

1972

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Studies of platelet 5-hydroxytryptamine (serotonin) in storage pool disease and albinism

The Journal of clinical investigation, 1974-08, Vol.54 (2), p.421-432

1974

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Platelet interaction with collagen fibrils in flowing blood. II. Impaired adhesion-aggregation in bleeding disorders. A comparison with subendothelium

Thrombosis and haemostasis, 1977-02, Vol.37 (1), p.17

1977

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INTERACTION OF PLATELETS WITH SUBENDOTHELIUM: A NEW METHOD FOR IDENTIFYING AND CLASSIFYING ABNORMALITIES OF PLATELET FUNCTION

Annals of the New York Academy of Sciences, 1977-02, Vol.283 (1), p.293-309

1977

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Platelet Function Tests in Disease

Annual review of medicine, 1973-01, Vol.24 (1), p.1-18

1973

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Inhibition of thrombosis on vascular catheters in cats

Radiology, 1973-01, Vol.106 (1), p.49

1973

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Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity

Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors

Can the calculation of ligand binding free energies be improved with continuum solvent electrostatics and an ideal‐gas entropy correction?

Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors

Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors

Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function

Active site-blocked factors VIIa and IXa differentially inhibit fibrin formation in a human ex vivo thrombosis model

Activated clotting time as a appropriate test to compare heparin and direct thrombin inhibitors such as hirudin or Ro 46-6240 in experimental arterial thrombosis

Endothelial cells stimulated with tumor necrosis factor-alpha express varying amounts of tissue factor resulting in inhomogenous fibrin deposition in a native blood flow system. Effects of thrombin inhibitors

Role of Collagen-Adherent Platelets in Mediating Fibrin Formation in Flowing Whole Blood

Relationship between tissue factor expression and deposition of fibrin, platelets, and leukocytes on cultured endothelial cells under venous blood flow conditions

Activated clotting time as an appropriate test to compare heparin and direct thrombin inhibitor such as hirudin or Ro 46-6240 in experimental arterial thrombosis

Identification of a sulfated tetrasaccharide with heparin-like antiproliferative activity

The heparin-like antiproliferative activity of sulfated tetrasaccharides is sensitive to structural variation

Heparin, carboxyl-reduced sulfated heparin, and Trestatin A sulfate. Antiproliferative and anticoagulant activities

The Development of Potent and Highly Selective Thrombin Inhibitors

Platelet adhesion, release and aggregation in flowing blood: effects of surface properties and platelet function

Synthesis of an N-Acetylated Heparin Pentasaccharide and its anticoagulant activity in comparison with the heparin pentasaccharide with high anti-factor-Xa activity

Decreased adhesion of giant (Bernard-Soulier) platelets to subendothelium: Further implications on the role of the von Willebrand factor in hemostasis

Hereditary Defect in Platelet Function in Rats

Studies of platelet 5-hydroxytryptamine (serotonin) in storage pool disease and albinism

Platelet interaction with collagen fibrils in flowing blood. II. Impaired adhesion-aggregation in bleeding disorders. A comparison with subendothelium

INTERACTION OF PLATELETS WITH SUBENDOTHELIUM: A NEW METHOD FOR IDENTIFYING AND CLASSIFYING ABNORMALITIES OF PLATELET FUNCTION

Platelet Function Tests in Disease

Inhibition of thrombosis on vascular catheters in cats

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