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Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins

Science (American Association for the Advancement of Science), 1999-06, Vol.284 (5420), p.1664-1666

1999

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Mechanism of Selective Inhibition of the Inducible Isoform of Prostaglandin G/H Synthase

Proceedings of the National Academy of Sciences - PNAS, 1994-11, Vol.91 (23), p.11202-11206

1994

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Aggrecan Protects Cartilage Collagen from Proteolytic Cleavage

The Journal of biological chemistry, 2003-11, Vol.278 (46), p.45539-45545

2003

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The MAPK cascade is required for mammalian associative learning

Nature neuroscience, 1998-11, Vol.1 (7), p.602-609

1998

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Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

The Journal of biological chemistry, 1998-07, Vol.273 (29), p.18623-18632

1998

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Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice

Cell, 1997-10, Vol.91 (2), p.197-208

1997

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A necessity for MAP kinase activation in mammalian spatial learning

Learning & memory (Cold Spring Harbor, N.Y.), 1999-09, Vol.6 (5), p.478-490

1999

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Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release

Journal of medicinal chemistry, 2001-10, Vol.44 (21), p.3351-3354

2001

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Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPAR delta

Genes & development, 1999-06, Vol.13 (12), p.1561-1574

1999

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Cyclooxygenase-2 Differentially Directs Uterine Angiogenesis during Implantation in Mice

The Journal of biological chemistry, 2002-08, Vol.277 (32), p.29260-29267

2002

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Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II

Nature (London), 1995-11, Vol.378 (6555), p.406-409

1995

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Hepatic cholesterol metabolism in patients with cholesterol gallstones: Enhanced intracellular transport of cholesterol

Gastroenterology (New York, N.Y. 1943), 1996-05, Vol.110 (5), p.1619-1627

1996

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Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy

The Journal of immunology (1950), 1998-05, Vol.160 (9), p.4175-4181

1998

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Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy

The Journal of biological chemistry, 2000-11, Vol.275 (47), p.37086-37092

2000

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Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity

The Journal of biological chemistry, 1999-03, Vol.274 (10), p.6594-6601

1999

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Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis

The Journal of biological chemistry, 1993-10, Vol.268 (30), p.22591-22599

1993

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Dependence of Dbl and Dbs Transformation on MEK and NF-κB Activation

Molecular and Cellular Biology, 1999-11, Vol.19 (11), p.7759-7770

1999

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Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the central ring and o-biphenyl analogs

Bioorganic & medicinal chemistry letters, 1999-04, Vol.9 (7), p.919-924

1999

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Mechanistic studies of lanosterol C-32 demethylation. Conditions which promote oxysterol intermediate accumulation during the demethylation process

The Journal of biological chemistry, 1986-12, Vol.261 (36), p.16937-16942

1986

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The Extracellular Signal-Regulated Kinase Cascade Is Required for NMDA Receptor-Independent LTP in Area CA1 But Not Area CA3 of the Hippocampus

The Journal of neuroscience, 2000-05, Vol.20 (9), p.3057-3066

2000

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Antiinflammatory 4,5-Diarylpyrroles. 2. Activity as a Function of Cyclooxygenase-2 Inhibition

Journal of medicinal chemistry, 1995-09, Vol.38 (20), p.3895-3901

1995

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Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation

The Journal of biological chemistry, 1984-11, Vol.259 (21), p.13402-13412

1984

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Inhibition of MAP Kinase Kinase (MEK) Results in an Anti-inflammatory Response in Vivo

Biochemical and biophysical research communications, 2000-02, Vol.268 (2), p.647-651

2000

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Receptor density dictates the behavior of a subset of steroid ligands in glucocorticoid receptor-mediated transrepression

International immunopharmacology, 2003-12, Vol.3 (13), p.1803-1817

2003

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Control of low density lipoprotein receptor gene promoter activity. Ketoconazole inhibits serum lipoprotein but not oxysterol suppression of gene transcription

The Journal of biological chemistry, 1989-07, Vol.264 (21), p.12352-12357

1989

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Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins

Mechanism of Selective Inhibition of the Inducible Isoform of Prostaglandin G/H Synthase

Aggrecan Protects Cartilage Collagen from Proteolytic Cleavage

The MAPK cascade is required for mammalian associative learning

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice

A necessity for MAP kinase activation in mammalian spatial learning

Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release

Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPAR delta

Cyclooxygenase-2 Differentially Directs Uterine Angiogenesis during Implantation in Mice

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II

Hepatic cholesterol metabolism in patients with cholesterol gallstones: Enhanced intracellular transport of cholesterol

Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy

Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy

Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity

Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis

Dependence of Dbl and Dbs Transformation on MEK and NF-κB Activation

Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the central ring and o-biphenyl analogs

Mechanistic studies of lanosterol C-32 demethylation. Conditions which promote oxysterol intermediate accumulation during the demethylation process

The Extracellular Signal-Regulated Kinase Cascade Is Required for NMDA Receptor-Independent LTP in Area CA1 But Not Area CA3 of the Hippocampus

Antiinflammatory 4,5-Diarylpyrroles. 2. Activity as a Function of Cyclooxygenase-2 Inhibition

Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation

Inhibition of MAP Kinase Kinase (MEK) Results in an Anti-inflammatory Response in Vivo

Receptor density dictates the behavior of a subset of steroid ligands in glucocorticoid receptor-mediated transrepression

Control of low density lipoprotein receptor gene promoter activity. Ketoconazole inhibits serum lipoprotein but not oxysterol suppression of gene transcription

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