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Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity

Molecular cancer therapeutics, 2007-07, Vol.6 (7), p.2012-2021

2007

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Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor

Journal of medicinal chemistry, 2008-08, Vol.51 (15), p.4632-4640

2008

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Impact of Common Epidermal Growth Factor Receptor and HER2 Variants on Receptor Activity and Inhibition by Lapatinib

Cancer research (Chicago, Ill.), 2008-01, Vol.68 (2), p.571-579

2008

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A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

Cancer research (Chicago, Ill.), 2004-09, Vol.64 (18), p.6652-6659

2004

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Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase

Bioorganic & medicinal chemistry letters, 2005-08, Vol.15 (15), p.3519-3523

2005

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Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.817-820

2009

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Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2- c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.250-254

2007

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Agouti Antagonism of Melanocortin Binding and Action in the B16F10 Murine Melanoma Cell Line

Biochemistry (Easton), 1995-08, Vol.34 (33), p.10406-10411

1995

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Orally active 4-amino-5-diarylurea-furo[2,3- d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1773-1778

2007

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Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: Implications for cellular potency and selectivity over insulin receptor

Biochemical pharmacology, 2009-12, Vol.78 (12), p.1438-1447

2009

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4-Acylamino-6-arylfuro[2,3- d]pyrimidines: potent and selective glycogen synthase kinase-3 inhibitors

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (15), p.3907-3911

2004

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A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib)

Cancer research (Chicago, Ill.), 2004-09, Vol.64 (18), p.6652-6659

2004

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Mutations in the Carboxyl Terminus of the Agouti Protein Decrease Agouti Inhibition of Ligand Binding to the Melanocortin Receptors

Biochemistry (Easton), 1997-02, Vol.36 (8), p.2084-2090

1997

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Proteoglycan expression by human trabecular meshworks

Current eye research, 1997, Vol.16 (5), p.412-421

1997

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Design and Effective Synthesis of Novel Templates, 3,7-Diphenyl-4-amino-thieno and Furo-[3,2-c]pyridines as Protein Kinase Inhibitors and in vitro Evaluation Targeting Angiogenetic Kinases

ChemInform, 2007-05, Vol.38 (19), p.no-no

2007

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4-Acylamino-6-arylfuro[2,3-d]pyrimidines: Potent and Selective Glycogen Synthase Kinase-3 Inhibitors

ChemInform, 2004-11, Vol.35 (46), p.no-no

2004

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Adaptive immune defects and delayed rejection of allogeneic tumor cells in beige mice

Cellular immunology, 1984-01, Vol.87 (2), p.348-356

1984

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Resistance to moloney murine sarcoma virus-induced tumorigenesis in NK-deficient beige mice

Cellular immunology, 1982-11, Vol.74 (1), p.120-125

1982

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Modeling 25 years of food web changes in Narragansett Bay (USA) as a tool for ecosystem-based management

Marine ecology. Progress series (Halstenbek), 2020-11, Vol.654, p.17-33

2020

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Recruitment strategies for predominantly low-income, multi-racial/ethnic children and parents to 3-year community-based intervention trials: Childhood Obesity Prevention and Treatment Research (COPTR) Consortium

Trials, 2019-05, Vol.20 (1), p.296-296, Article 296

2019

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Respiratory-associated deaths in people with intellectual disabilities: a systematic review and meta-analysis

BMJ open, 2021-07, Vol.11 (7), p.e043658-e043658

2021

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Clinical Care of Two Patients with Ebola Virus Disease in the United States

The New England journal of medicine, 2014-12, Vol.371 (25), p.2402-2409

2014

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Rates, causes and predictors of all-cause and avoidable mortality in 163 686 children and young people with and without intellectual disabilities: a record linkage national cohort study

BMJ open, 2022-09, Vol.12 (9), p.e061636-e061636

2022

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Multicomponent Obesity Prevention Intervention in Low-Income Preschoolers: Primary and Subgroup Analyses of the NET-Works Randomized Clinical Trial, 2012-2017

American journal of public health (1971), 2018-12, Vol.108 (12), p.1695-1706

2018

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Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

Nature (London), 1994-08, Vol.370 (6490), p.558-561

1994

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Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity

Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor

Impact of Common Epidermal Growth Factor Receptor and HER2 Variants on Receptor Activity and Inhibition by Lapatinib

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase

Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors

Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2- c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases

Agouti Antagonism of Melanocortin Binding and Action in the B16F10 Murine Melanoma Cell Line

Orally active 4-amino-5-diarylurea-furo[2,3- d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2

Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: Implications for cellular potency and selectivity over insulin receptor

4-Acylamino-6-arylfuro[2,3- d]pyrimidines: potent and selective glycogen synthase kinase-3 inhibitors

A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib)

Mutations in the Carboxyl Terminus of the Agouti Protein Decrease Agouti Inhibition of Ligand Binding to the Melanocortin Receptors

Proteoglycan expression by human trabecular meshworks

Design and Effective Synthesis of Novel Templates, 3,7-Diphenyl-4-amino-thieno and Furo-[3,2-c]pyridines as Protein Kinase Inhibitors and in vitro Evaluation Targeting Angiogenetic Kinases

4-Acylamino-6-arylfuro[2,3-d]pyrimidines: Potent and Selective Glycogen Synthase Kinase-3 Inhibitors

Adaptive immune defects and delayed rejection of allogeneic tumor cells in beige mice

Resistance to moloney murine sarcoma virus-induced tumorigenesis in NK-deficient beige mice

Modeling 25 years of food web changes in Narragansett Bay (USA) as a tool for ecosystem-based management

Recruitment strategies for predominantly low-income, multi-racial/ethnic children and parents to 3-year community-based intervention trials: Childhood Obesity Prevention and Treatment Research (COPTR) Consortium

Respiratory-associated deaths in people with intellectual disabilities: a systematic review and meta-analysis

Clinical Care of Two Patients with Ebola Virus Disease in the United States

Rates, causes and predictors of all-cause and avoidable mortality in 163 686 children and young people with and without intellectual disabilities: a record linkage national cohort study

Multicomponent Obesity Prevention Intervention in Low-Income Preschoolers: Primary and Subgroup Analyses of the NET-Works Randomized Clinical Trial, 2012-2017

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

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