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Microsecond Simulations Indicate that Ethanol Binds between Subunits and Could Stabilize an Open-State Model of a Glycine Receptor

Biophysical journal, 2011-04, Vol.100 (7), p.1642-1650

2011

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Ethanol's molecular targets

Science signaling, 2008-07, Vol.1 (28), p.re7

2008

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Emerging molecular mechanisms of general anesthetic action

Trends in pharmacological sciences (Regular ed.), 2005-10, Vol.26 (10), p.503-510

2005

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Stabilization of the GluCl Ligand-Gated Ion Channel in the Presence and Absence of Ivermectin

Biophysical journal, 2013-08, Vol.105 (3), p.640-647

2013

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Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (29), p.12149-12154

2011

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Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity

International journal of molecular sciences, 2020-04, Vol.21 (7), p.2471

2020

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Coupling of agonist binding to channel gating in the GABAa receptor

Nature (London), 2003-01, Vol.421 (6920), p.272-275

2003

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P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders

Frontiers in neuroscience, 2014-06, Vol.8, p.176-176

2014

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Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

PLoS computational biology, 2012-10, Vol.8 (10), p.e1002710-e1002710

2012

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Inhibition versus Potentiation of Ligand-Gated Ion Channels Can Be Altered by a Single Mutation that Moves Ligands between Intra- and Intersubunit Sites

Structure (London), 2013-08, Vol.21 (8), p.1307-1316

2013

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Zinc-Dependent Modulation of α2- and α3-Glycine Receptor Subunits by Ethanol

Alcoholism, clinical and experimental research, 2013-12, Vol.37 (12), p.2002-2010

2013

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Molecular targets and mechanisms for ethanol action in glycine receptors

Pharmacology & therapeutics (Oxford), 2010-07, Vol.127 (1), p.53-65

2010

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Alcohol dependence: molecular and behavioral evidence

Trends in pharmacological sciences (Regular ed.), 2014-07, Vol.35 (7), p.317-323

2014

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Specific Binding Sites for Alcohols and Anesthetics on Ligand-Gated Ion Channels

Proceedings of the National Academy of Sciences - PNAS, 2000-08, Vol.97 (16), p.9305-9310

2000

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Loop 2 Structure in Glycine and GABAA Receptors Plays a Key Role in Determining Ethanol Sensitivity

The Journal of biological chemistry, 2009-10, Vol.284 (40), p.27304-27314

2009

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Endothelial Fate Mapping in Mice With Pulmonary Hypertension

Circulation (New York, N.Y.), 2014-02, Vol.129 (6), p.692-703

2014

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Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics

Pharmacological reviews, 2014-04, Vol.66 (2), p.396-412

2014

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Mutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo

The Journal of pharmacology and experimental therapeutics, 2013-02, Vol.344 (2), p.489-500

2013

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Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation

Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (17), p.7987-7992

2010

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Assessment of Homology Templates and an Anesthetic Binding Site within the γ-Aminobutyric Acid Receptor

Anesthesiology (Philadelphia), 2013-11, Vol.119 (5), p.1087-1095

2013

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Modulation of α1β3γ2 GABAA receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (8), p.1-8

2021

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Channel Gating of the Glycine Receptor Changes Accessibility to Residues Implicated in Receptor Potentiation by Alcohols and Anesthetics

The Journal of biological chemistry, 2004-08, Vol.279 (32), p.33919-33927

2004

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An intersubunit electrostatic interaction in the GABAA receptor facilitates its responses to benzodiazepines

The Journal of biological chemistry, 2018-05, Vol.293 (21), p.8264-8274

2018

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Modulation of α1β3γ2 GABA A receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (8)

2021

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Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors

The Journal of pharmacology and experimental therapeutics, 2010-09, Vol.334 (3), p.720-728

2010

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Microsecond Simulations Indicate that Ethanol Binds between Subunits and Could Stabilize an Open-State Model of a Glycine Receptor

Ethanol's molecular targets

Emerging molecular mechanisms of general anesthetic action

Stabilization of the GluCl Ligand-Gated Ion Channel in the Presence and Absence of Ivermectin

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity

Coupling of agonist binding to channel gating in the GABAa receptor

P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

Inhibition versus Potentiation of Ligand-Gated Ion Channels Can Be Altered by a Single Mutation that Moves Ligands between Intra- and Intersubunit Sites

Zinc-Dependent Modulation of α2- and α3-Glycine Receptor Subunits by Ethanol

Molecular targets and mechanisms for ethanol action in glycine receptors

Alcohol dependence: molecular and behavioral evidence

Specific Binding Sites for Alcohols and Anesthetics on Ligand-Gated Ion Channels

Loop 2 Structure in Glycine and GABAA Receptors Plays a Key Role in Determining Ethanol Sensitivity

Endothelial Fate Mapping in Mice With Pulmonary Hypertension

Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics

Mutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo

Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation

Assessment of Homology Templates and an Anesthetic Binding Site within the γ-Aminobutyric Acid Receptor

Modulation of α1β3γ2 GABAA receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix

Channel Gating of the Glycine Receptor Changes Accessibility to Residues Implicated in Receptor Potentiation by Alcohols and Anesthetics

An intersubunit electrostatic interaction in the GABAA receptor facilitates its responses to benzodiazepines

Modulation of α1β3γ2 GABA A receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix

Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors

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