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TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity

Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (20), p.8485-8490

2011

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Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

Scientific reports, 2021-04, Vol.11 (1), p.7700-7700, Article 7700

2021

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selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system

Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (47), p.20081-20086

2009

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RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

Psychopharmacology, 2009-01, Vol.202 (1-3), p.207-223

2009

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The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (20), p.5940-5944

2009

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A Virtual Screening Method for Prediction of the hERG Potassium Channel Liability of Compound Libraries

Chembiochem : a European journal of chemical biology, 2002-05, Vol.3 (5), p.455-459

2002

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Activation of GABAA Receptors by Guanidinoacetate: A Novel Pathophysiological Mechanism

Neurobiology of disease, 2002-11, Vol.11 (2), p.298-307

2002

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Evaluation of a High-Throughput Fluorescence Assay Method for hERG Potassium Channel Inhibition

Journal of biomolecular screening, 2005-06, Vol.10 (4), p.339-347

2005

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Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5746-5752

2009

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Functional Consequences of Reduction in NMDA Receptor Glycine Affinity in Mice Carrying Targeted Point Mutations in the Glycine Binding Site

The Journal of neuroscience, 2000-06, Vol.20 (11), p.4037-4049

2000

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Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons

European journal of pharmacology, 1993-07, Vol.238 (2), p.209-216

1993

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Alterations in High-Frequency Neuronal Oscillations in a Cynomolgus Macaque Test of Sustained Attention Following NMDA Receptor Antagonism

Neuropsychopharmacology (New York, N.Y.), 2016-04, Vol.41 (5), p.1319-1328

2016

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Activation of GABA A Receptors by Guanidinoacetate: A Novel Pathophysiological Mechanism

Neurobiology of disease, 2002-11, Vol.11 (2), p.298-307

2002

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Basmisanil, a highly selective GABA A -α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

Scientific reports, 2021-04, Vol.11 (1), p.7700

2021

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A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones

The Journal of physiology, 1996-12, Vol.497 (Pt 3), p.761-772

1996

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The effect of subunit composition of rat brain GABA A receptors on channel function

Neuron (Cambridge, Mass.), 1990-11, Vol.5 (5), p.703-711

1990

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The effect of subunit composition of rat brain GABAA receptors on channel function

Neuron (Cambridge, Mass.), 1990-11, Vol.5 (5), p.703-711

1990

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Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABAA α5 inverse agonists with potential for the treatment of cognitive dysfunction

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (20), p.5958-5961

2009

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Pharmacokinetic profiling and behavior characterization of a GalR3 antagonist

The FASEB journal, 2008-03, Vol.22 (S1)

2008

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The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABA sub(A) alpha 5 inverse agonists for the treatment of cognitive dysfunction

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (20), p.5940-5944

2009

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Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABA sub(A) alpha 5 inverse agonists with potential for the treatment of cognitive dysfunction

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (20), p.5958-5961

2009

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Imidazo[1,5- a][1,2,4]-triazolo[1,5- d][1,4]benzodiazepines as potent and highly selective GABA A α5 inverse agonists with potential for the treatment of cognitive dysfunction

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (20), p.5958-5961

2009

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The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABA A α5 inverse agonists for the treatment of cognitive dysfunction

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (20), p.5940-5944

2009

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The discovery and unique pharmacological profile of RO4938581 and R04882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (20), p.5940-5944

2009

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RO4938581, a novel cognitive enhancer acting at GABAA [alpha]5 subunit-containing receptors

Psychopharmacology, 2009-01, Vol.202 (1-3), p.207

2009

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TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity

Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system

RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction

A Virtual Screening Method for Prediction of the hERG Potassium Channel Liability of Compound Libraries

Activation of GABAA Receptors by Guanidinoacetate: A Novel Pathophysiological Mechanism

Evaluation of a High-Throughput Fluorescence Assay Method for hERG Potassium Channel Inhibition

Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series

Functional Consequences of Reduction in NMDA Receptor Glycine Affinity in Mice Carrying Targeted Point Mutations in the Glycine Binding Site

Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons

Alterations in High-Frequency Neuronal Oscillations in a Cynomolgus Macaque Test of Sustained Attention Following NMDA Receptor Antagonism

Activation of GABA A Receptors by Guanidinoacetate: A Novel Pathophysiological Mechanism

Basmisanil, a highly selective GABA A -α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones

The effect of subunit composition of rat brain GABA A receptors on channel function

The effect of subunit composition of rat brain GABAA receptors on channel function

Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABAA α5 inverse agonists with potential for the treatment of cognitive dysfunction

Pharmacokinetic profiling and behavior characterization of a GalR3 antagonist

The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABA sub(A) alpha 5 inverse agonists for the treatment of cognitive dysfunction

Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABA sub(A) alpha 5 inverse agonists with potential for the treatment of cognitive dysfunction

Imidazo[1,5- a][1,2,4]-triazolo[1,5- d][1,4]benzodiazepines as potent and highly selective GABA A α5 inverse agonists with potential for the treatment of cognitive dysfunction

The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABA A α5 inverse agonists for the treatment of cognitive dysfunction

The discovery and unique pharmacological profile of RO4938581 and R04882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction

RO4938581, a novel cognitive enhancer acting at GABAA [alpha]5 subunit-containing receptors

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