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Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease

Frontiers in pharmacology, 2021-07, Vol.12, p.701301-701301

2021

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Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions

Cell, 2014-08, Vol.158 (5), p.1159-1172

2014

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Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling

Brain (London, England : 1878), 2014-06, Vol.137 (Pt 6), p.1656-1675

2014

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Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

Annals of neurology, 2011-05, Vol.69 (5), p.819-830

2011

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Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics

Cell death & disease, 2022-11, Vol.13 (11), p.959-959, Article 959

2022

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Mechanisms of neuronal death in disease: defining the models and the players

Biochemical journal, 2008-10, Vol.415 (2), p.165-182

2008

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Caspase Inhibitors: Prospective Therapies for Stroke

The Neuroscientist (Baltimore, Md.), 2013-04, Vol.19 (2), p.129-136

2013

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Caspases: Therapeutic Targets in Neurologic Disease

Neurotherapeutics, 2015-01, Vol.12 (1), p.42-48

2015

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Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice

Nature communications, 2013-01, Vol.4 (1), p.1939-1939, Article 1939

2013

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Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline

Cell death & disease, 2022-11, Vol.13 (11), p.937-937, Article 937

2022

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Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion

Frontiers in neuroscience, 2023-06, Vol.17, p.1209527

2023

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Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant

American journal of human genetics, 2016-11, Vol.99 (5), p.1117-1129

2016

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The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of Neurodegeneration

The Journal of neuroscience, 2009-01, Vol.29 (4), p.1011-1016

2009

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Correction: Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline

Cell death & disease, 2022-11, Vol.13 (11), p.993-993, Article 993

2022

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Cystatin C protects neuronal cells from amyloid-beta-induced toxicity

Journal of Alzheimer's disease, 2010-01, Vol.19 (3), p.885-894

2010

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Caspase-2 and tau-a toxic partnership?

Nature medicine, 2016-11, Vol.22 (11), p.1207-1208

2016

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Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection

Molecular neurodegeneration, 2012-12, Vol.7 (1), p.60-60, Article 60

2012

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Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Journal of visualized experiments, 2021-08 (174)

2021

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Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion

Nature communications, 2020-07, Vol.11 (1), p.3502-3502, Article 3502

2020

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Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways

The Journal of neuroscience, 2009-07, Vol.29 (27), p.8828-8838

2009

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The Matrix Receptor CD44 Is Present in Astrocytes throughout the Human Central Nervous System and Accumulates in Hypoxia and Seizures

Cells (Basel, Switzerland), 2024-01, Vol.13 (2), p.129

2024

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Regulation of caspases in the nervous system implications for functions in health and disease

Progress in molecular biology and translational science, 2011, Vol.99, p.265-305

2011

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In vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility

Journal of visualized experiments, 2022-04 (182)

2022

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Neuronal caspase 2 activity and function requires RAIDD, but not PIDD

Biochemical journal, 2012-06, Vol.444 (3), p.591-599

2012

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Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Journal of visualized experiments, 2015-06 (100), p.e52805

2015

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Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions

Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics

Mechanisms of neuronal death in disease: defining the models and the players

Caspase Inhibitors: Prospective Therapies for Stroke

Caspases: Therapeutic Targets in Neurologic Disease

Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice

Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline

Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion

Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant

The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of Neurodegeneration

Correction: Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline

Cystatin C protects neuronal cells from amyloid-beta-induced toxicity

Caspase-2 and tau-a toxic partnership?

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion

Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways

The Matrix Receptor CD44 Is Present in Astrocytes throughout the Human Central Nervous System and Accumulates in Hypoxia and Seizures

Regulation of caspases in the nervous system implications for functions in health and disease

In vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility

Neuronal caspase 2 activity and function requires RAIDD, but not PIDD

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

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