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Preclinical Toxicity, Toxicokinetics, and Antitumoral Efficacy Studies of DTS-201, a Tumor-Selective Peptidic Prodrug of Doxorubicin

Clinical cancer research, 2008-02, Vol.14 (4), p.1258-1265

2008

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First-in-man phase I study assessing the safety and pharmacokinetics of a 1-hour intravenous infusion of the doxorubicin prodrug DTS-201 every 3 weeks in patients with advanced or metastatic solid tumours

European journal of cancer (1990), 2017-11, Vol.86, p.240-247

2017

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Improved Therapeutic Efficacy of Doxorubicin through Conjugation with a Novel Peptide Drug Delivery Technology (Vectocell)

Journal of medicinal chemistry, 2006-11, Vol.49 (23), p.6908-6916

2006

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Transport Mechanisms of the Large Neutral Amino Acid L-Phenylalanine in the Human Intestinal Epithelial Caco-2 Cell Line

The Journal of nutrition, 2000-11, Vol.130 (11), p.2780-2788

2000

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Antioxidative properties of natural coelenterazine and synthetic methyl coelenterazine in rat hepatocytes subjected to tert-butyl hydroperoxide-induced oxidative stress

Biochemical pharmacology, 2000-08, Vol.60 (4), p.471-478

2000

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Abstract 5353: Efficacy of an innovative, enzyme-activated doxorubicin prodrug in patient-derived dedifferentiated liposarcoma and synovial sarcoma xenograft models

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5353-5353

2015

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Extracellularly tumor-activated prodrugs for the selective chemotherapy of cancer : Application to doxorubicin and preliminary in vitro and in vivo studies

Cancer research (Chicago, Ill.), 2001-04, Vol.61 (7), p.2843-2846

2001

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Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2)

Toxicology letters, 2003-04, Vol.140, p.465-476

2003

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CPI-0004Na, a new extracellularly tumor-activated prodrug of doxorubicin: In vivo toxicity, activity, and tissue distribution confirm tumor cell selectivity

Cancer research (Chicago, Ill.), 2002-04, Vol.62 (8), p.2327-2331

2002

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Compartmentalized coculture of porcine arterial endothelial and smooth muscle cells on a microporous membrane

In vitro cellular & developmental biology. Animal, 1997-02, Vol.33 (2), p.92-103

1997

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Transport Mechanisms of the Imino Acid L-Proline in the Human Intestinal Epithelial Caco-2 Cell Line

The Journal of nutrition, 2000-11, Vol.130 (11), p.2772-2779

2000

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The uptake and intracellular accumulation of aminoglycoside antibiotics in lysosomes of cultured rat fibroblasts

Biochemical pharmacology, 1978-02, Vol.27 (4), p.415-424

1978

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N-Succinyl-(β-alanyl-l-leucyl-l-alanyl-l-leucyl)doxorubicin: An Extracellularly Tumor-Activated Prodrug Devoid of Intravenous Acute Toxicity

Journal of medicinal chemistry, 2001-10, Vol.44 (22), p.3750-3753

2001

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GABA induces down-regulation of the benzodiazepine-GABA receptor complex in the rat cultured neurons

European journal of pharmacology, 1987-12, Vol.144 (2), p.173-183

1987

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Effects of Antimycin, Glucose Deprivation, and Serum on Cultures of Neurons, Astrocytes, and Neuroblastoma Cells

Journal of neurochemistry, 1985-01, Vol.44 (1), p.143-148

1985

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Analytical Fractionation of Homogenates from Cultured Rat Embryo Fibroblasts

The Journal of cell biology, 1974-11, Vol.63 (2), p.383-401

1974

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Smooth Muscle Cells Influence Monocyte Response to LDL as well as Their Adhesion and Transmigration in a Coculture Model of the Arterial Wall

Journal of vascular research, 2001-09, Vol.38 (5), p.479-491

2001

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Coelenterazine: a two-stage antioxidant in lipid micelles

Free radical biology & medicine, 2004-02, Vol.36 (3), p.278-287

2004

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S-nitrosothiols do not induce oxidative stress, contrary to other nitric oxide donors, in cultures of vascular endothelial or smooth muscle cells

European journal of pharmacology, 2001-08, Vol.425 (1), p.11-19

2001

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Protection against nitrofurantoin-induced oxidative stress by coelenterazine analogues and their oxidation products in rat hepatocytes

Free radical research, 2001-01, Vol.34 (3), p.285-296

2001

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Transferrin protein and iron uptake by cultured rat fibroblasts

FEBS letters, 1979-12, Vol.108 (1), p.127-130

1979

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CPI-0004Na, a new doxorubicin prodrug, reduces growth of 3LL-H61 carcinoma lung metastases in C57BI/6 mice

Journal of experimental therapeutics & oncology, 2004-07, Vol.4 (2), p.167

2004

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[31] Isolation of modified liver lysosomes

Methods in Enzymology, 1974, Vol.31, p.323-329

Trouet, André

1974

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Lysosomotropic agents

Biochemical pharmacology, 1974-01, Vol.23 (18), p.2495,IN1,2511-2510,IN3,2531

1974

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Increased selectivity of drugs by linking to carriers

European journal of cancer, 1978-01, Vol.14 (2), p.105-111

Trouet, André

1978

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Preclinical Toxicity, Toxicokinetics, and Antitumoral Efficacy Studies of DTS-201, a Tumor-Selective Peptidic Prodrug of Doxorubicin

First-in-man phase I study assessing the safety and pharmacokinetics of a 1-hour intravenous infusion of the doxorubicin prodrug DTS-201 every 3 weeks in patients with advanced or metastatic solid tumours

Improved Therapeutic Efficacy of Doxorubicin through Conjugation with a Novel Peptide Drug Delivery Technology (Vectocell)

Transport Mechanisms of the Large Neutral Amino Acid L-Phenylalanine in the Human Intestinal Epithelial Caco-2 Cell Line

Antioxidative properties of natural coelenterazine and synthetic methyl coelenterazine in rat hepatocytes subjected to tert-butyl hydroperoxide-induced oxidative stress

Abstract 5353: Efficacy of an innovative, enzyme-activated doxorubicin prodrug in patient-derived dedifferentiated liposarcoma and synovial sarcoma xenograft models

Extracellularly tumor-activated prodrugs for the selective chemotherapy of cancer : Application to doxorubicin and preliminary in vitro and in vivo studies

Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2)

CPI-0004Na, a new extracellularly tumor-activated prodrug of doxorubicin: In vivo toxicity, activity, and tissue distribution confirm tumor cell selectivity

Compartmentalized coculture of porcine arterial endothelial and smooth muscle cells on a microporous membrane

Transport Mechanisms of the Imino Acid L-Proline in the Human Intestinal Epithelial Caco-2 Cell Line

The uptake and intracellular accumulation of aminoglycoside antibiotics in lysosomes of cultured rat fibroblasts

N-Succinyl-(β-alanyl-l-leucyl-l-alanyl-l-leucyl)doxorubicin: An Extracellularly Tumor-Activated Prodrug Devoid of Intravenous Acute Toxicity

GABA induces down-regulation of the benzodiazepine-GABA receptor complex in the rat cultured neurons

Effects of Antimycin, Glucose Deprivation, and Serum on Cultures of Neurons, Astrocytes, and Neuroblastoma Cells

Analytical Fractionation of Homogenates from Cultured Rat Embryo Fibroblasts

Smooth Muscle Cells Influence Monocyte Response to LDL as well as Their Adhesion and Transmigration in a Coculture Model of the Arterial Wall

Coelenterazine: a two-stage antioxidant in lipid micelles

S-nitrosothiols do not induce oxidative stress, contrary to other nitric oxide donors, in cultures of vascular endothelial or smooth muscle cells

Protection against nitrofurantoin-induced oxidative stress by coelenterazine analogues and their oxidation products in rat hepatocytes

Transferrin protein and iron uptake by cultured rat fibroblasts

CPI-0004Na, a new doxorubicin prodrug, reduces growth of 3LL-H61 carcinoma lung metastases in C57BI/6 mice

[31] Isolation of modified liver lysosomes

Lysosomotropic agents

Increased selectivity of drugs by linking to carriers

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