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Enteric reabsorption processes and their impact on drug pharmacokinetics

Scientific reports, 2021-03, Vol.11 (1), p.5794-17, Article 5794

2021

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Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis

Journal of antimicrobial chemotherapy, 2014-01, Vol.69 (1), p.180-189

2014

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Gene Therapy: A Pharmacokinetic/Pharmacodynamic Modelling Overview

Pharmaceutical research, 2010-08, Vol.27 (8), p.1487-1497

2010

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IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity

Trials, 2022-09, Vol.23 (1), p.739-739, Article 739

2022

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Semi-mechanistic population pharmacokinetic/pharmacodynamic model for neutropenia following therapy with the Plk-1 inhibitor BI 2536 and its application in clinical development

Cancer chemotherapy and pharmacology, 2010-09, Vol.66 (4), p.785-795

2010

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Disentangling Anti-Tumor Response of Immunotherapy Combinations: A Physiologically Based Framework for V937 Oncolytic Virus and Pembrolizumab

Clinical pharmacology and therapeutics, 2024-07

2024

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How to use meropenem in pediatric patients undergoing CKRT? Integrated meropenem pharmacokinetic model for critically ill children

Antimicrobial agents and chemotherapy, 2024-04

2024

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Mechanism-Based Modeling of Perioperative Variations in Hemoglobin Concentration in Patients Undergoing Laparoscopic Surgery

Anesthesia and analgesia, 2024-01, Vol.138 (1), p.141

2024

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Dual activity of PD-L1 targeted Doxorubicin immunoliposomes promoted an enhanced efficacy of the antitumor immune response in melanoma murine model

Journal of nanobiotechnology, 2021-04, Vol.19 (1), p.102-102, Article 102

2021

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A Quantitative Systems Pharmacology Model for the Key Interleukins Involved in Crohn's Disease

The Journal of pharmacology and experimental therapeutics, 2020-03, Vol.372 (3), p.299-307

2020

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A physiologically based pharmacokinetic model for V937 oncolytic virus in mice

Frontiers in pharmacology, 2023-09, Vol.14, p.1211452-1211452

2023

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Assessment of Clinical Response to V937 Oncolytic Virus After Intravenous or Intratumoral Administration Using Physiologically‐Based Modeling

Clinical pharmacology and therapeutics, 2023-09, Vol.114 (3), p.623-632

2023

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Model‐Informed Dose Selection for Xentuzumab, a Dual Insulin‐Like Growth Factor‐I/II—Neutralizing Antibody

Clinical pharmacology and therapeutics, 2020-03, Vol.107 (3), p.597-606

2020

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Comparison of two pharmacokinetic–pharmacodynamic models of rocuronium bromide during profound neuromuscular block: analysis of estimated and measured post-tetanic count effect

British journal of anaesthesia : BJA, 2022-03, Vol.128 (3), p.473-481

2022

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Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies

Investigational new drugs, 2011-10, Vol.29 (5), p.984-995

2011

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A new immune-nanoplatform for promoting adaptive antitumor immune response

Nanomedicine, 2019-04, Vol.17, p.13-25

2019

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Mechanistic Modeling of a Novel Oncolytic Virus, V937, to Describe Viral Kinetic and Dynamic Processes Following Intratumoral and Intravenous Administration

Frontiers in pharmacology, 2021-07, Vol.12, p.705443-705443

2021

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Population pharmacokinetics of sublingually administered tacrolimus in infants and young children with liver transplantation

British journal of clinical pharmacology, 2023-03, Vol.89 (3), p.1115-1126

2023

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Characterizing Gemcitabine Effects Administered as Single Agent or Combined with Carboplatin in Mice Pancreatic and Ovarian Cancer Xenografts: A Semimechanistic Pharmacokinetic/Pharmacodynamics Tumor Growth-Response Model

The Journal of pharmacology and experimental therapeutics, 2017-03, Vol.360 (3), p.445-456

2017

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Predicting tumour growth and its impact on survival in gemcitabine-treated patients with advanced pancreatic cancer

European journal of pharmaceutical sciences, 2018-03, Vol.115, p.296-303

2018

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Population pharmacokinetics of piperacillin in critically ill children including those undergoing continuous kidney replacement therapy

Clinical microbiology and infection, 2022-09, Vol.28 (9), p.1287-1287.e15

2022

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Translational Framework Predicting Tumour Response in Gemcitabine-Treated Patients with Advanced Pancreatic and Ovarian Cancer from Xenograft Studies

The AAPS journal, 2019-03, Vol.21 (2), p.23-23, Article 23

2019

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Disease pharmacokinetic–pharmacodynamic modelling in acute intermittent porphyria to support the development of mRNA‐based therapies

British journal of pharmacology, 2020-07, Vol.177 (14), p.3168-3182

2020

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Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development

International journal of molecular sciences, 2022-07, Vol.23 (15), p.8295

2022

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Systematic Modeling and Design Evaluation of Unperturbed Tumor Dynamics in Xenografts

The Journal of pharmacology and experimental therapeutics, 2018-07, Vol.366 (1), p.96-104

2018

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Enteric reabsorption processes and their impact on drug pharmacokinetics

Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis

Gene Therapy: A Pharmacokinetic/Pharmacodynamic Modelling Overview

Semi-mechanistic population pharmacokinetic/pharmacodynamic model for neutropenia following therapy with the Plk-1 inhibitor BI 2536 and its application in clinical development

Disentangling Anti-Tumor Response of Immunotherapy Combinations: A Physiologically Based Framework for V937 Oncolytic Virus and Pembrolizumab

How to use meropenem in pediatric patients undergoing CKRT? Integrated meropenem pharmacokinetic model for critically ill children

Mechanism-Based Modeling of Perioperative Variations in Hemoglobin Concentration in Patients Undergoing Laparoscopic Surgery

Dual activity of PD-L1 targeted Doxorubicin immunoliposomes promoted an enhanced efficacy of the antitumor immune response in melanoma murine model

A Quantitative Systems Pharmacology Model for the Key Interleukins Involved in Crohn's Disease

A physiologically based pharmacokinetic model for V937 oncolytic virus in mice

Assessment of Clinical Response to V937 Oncolytic Virus After Intravenous or Intratumoral Administration Using Physiologically‐Based Modeling

Model‐Informed Dose Selection for Xentuzumab, a Dual Insulin‐Like Growth Factor‐I/II—Neutralizing Antibody

Comparison of two pharmacokinetic–pharmacodynamic models of rocuronium bromide during profound neuromuscular block: analysis of estimated and measured post-tetanic count effect

Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies

A new immune-nanoplatform for promoting adaptive antitumor immune response

Mechanistic Modeling of a Novel Oncolytic Virus, V937, to Describe Viral Kinetic and Dynamic Processes Following Intratumoral and Intravenous Administration

Population pharmacokinetics of sublingually administered tacrolimus in infants and young children with liver transplantation

Characterizing Gemcitabine Effects Administered as Single Agent or Combined with Carboplatin in Mice Pancreatic and Ovarian Cancer Xenografts: A Semimechanistic Pharmacokinetic/Pharmacodynamics Tumor Growth-Response Model

Predicting tumour growth and its impact on survival in gemcitabine-treated patients with advanced pancreatic cancer

Population pharmacokinetics of piperacillin in critically ill children including those undergoing continuous kidney replacement therapy

Translational Framework Predicting Tumour Response in Gemcitabine-Treated Patients with Advanced Pancreatic and Ovarian Cancer from Xenograft Studies

Disease pharmacokinetic–pharmacodynamic modelling in acute intermittent porphyria to support the development of mRNA‐based therapies

Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development

Systematic Modeling and Design Evaluation of Unperturbed Tumor Dynamics in Xenografts

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