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Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors

Clinical pharmacokinetics, 2019-07, Vol.58 (7), p.835-857

2019

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Beyond Deterministic Models in Drug Discovery and Development

Trends in pharmacological sciences (Regular ed.), 2020-11, Vol.41 (11), p.882-895

2020

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Pharmacokinetic Profiles Determine Optimal Combination Treatment Schedules in Computational Models of Drug Resistance

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16), p.3372-3382

2020

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Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment

PLoS computational biology, 2023-10, Vol.19 (10), p.e1011507-e1011507

2023

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Population-Pharmacokinetic and Covariate Analysis of Lurbinectedin (PM01183), a New RNA Polymerase II Inhibitor, in Pooled Phase I/II Trials in Patients with Cancer

Clinical pharmacokinetics, 2019-03, Vol.58 (3), p.363-374

2019

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Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation

European journal of pharmaceutical sciences, 2023-04, Vol.183, p.106399-106399, Article 106399

2023

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Optimal dynamic control approach in a multi-objective therapeutic scenario: Application to drug delivery in the treatment of prostate cancer

PLoS computational biology, 2018-04, Vol.14 (4), p.e1006087

2018

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A systems pharmacology model for inflammatory bowel disease

PloS one, 2018-03, Vol.13 (3), p.e0192949

2018

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Advanced Boolean modeling of biological networks applied to systems pharmacology

Bioinformatics (Oxford, England), 2017-04, Vol.33 (7), p.1040-1048

2017

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Machine Learning Analysis of Individual Tumor Lesions in Four Metastatic Colorectal Cancer Clinical Studies: Linking Tumor Heterogeneity to Overall Survival

The AAPS journal, 2020-03, Vol.22 (3), p.58-58, Article 58

2020

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Relevance of primary lesion location, tumour heterogeneity and genetic mutation demonstrated through tumour growth inhibition and overall survival modelling in metastatic colorectal cancer

British journal of clinical pharmacology, 2022-01, Vol.88 (1), p.166-177

2022

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Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice

Acta pharmacologica Sinica, 2024-07

2024

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The Role of Mathematical Models in Immuno-Oncology: Challenges and Future Perspectives

Pharmaceutics, 2021-07, Vol.13 (7), p.1016

2021

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The Long Neglected Player: Modeling Tumor Uptake to Guide Optimal Dosing

Clinical cancer research, 2018-07, Vol.24 (14), p.3236-3238

2018

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Drug Exposure to Establish Pharmacokinetic–Response Relationships in Oncology

Clinical pharmacokinetics, 2020-02, Vol.59 (2), p.123-135

2020

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Physiologically-Based Pharmacokinetic model for Ciprofloxacin in children with complicated Urinary Tract Infection

European journal of pharmaceutical sciences, 2019-02, Vol.128, p.171-179

2019

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Untangling Absorption Mechanisms and Variability in Bioequivalence Studies Using Population Analysis

Pharmaceutical research, 2021-12, Vol.38 (12), p.2047-2063

2021

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Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-β kinase antagonist, in mice

European journal of cancer (1990), 2008-01, Vol.44 (1), p.142-150

2008

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Neoadjuvant therapy for locally advanced gastric cancer patients. A population pharmacodynamic modeling

PloS one, 2019-05, Vol.14 (5), p.e0215970-e0215970

2019

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Tramadol and O-Desmethyl Tramadol Clearance Maturation and Disposition in Humans: A Pooled Pharmacokinetic Study

Clinical pharmacokinetics, 2015-02, Vol.54 (2), p.167-178

2015

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Model-Based Meta-Analysis Supporting the Combination of Acetaminophen and Topical Diclofenac in Acute Pain: A Therapy for Mild-to-Moderate Osteoarthritis Pain?

Pain and therapy, 2024-02, Vol.13 (1), p.145-159

2024

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Model-Based Assessment of the Liver Safety Profile of Acetaminophen to Support its Combination Use with Topical Diclofenac in Mild-to-Moderate Osteoarthritis Pain

Pain and therapy, 2024-02, Vol.13 (1), p.127-143

2024

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Mechanistic modelling of enzyme‐restoration effects of new recombinant liver‐targeted proteins in acute intermittent porphyria

British journal of pharmacology, 2022-07, Vol.179 (14), p.3815-3830

2022

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Modulation of intratumoural myeloid cells, the hallmark of the anti-tumour efficacy induced by a triple combination: tumour-associated peptide, TLR-3 ligand and α-PD-1

British journal of cancer, 2021-03, Vol.124 (7), p.1275-1285

2021

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Modelling of neutrophil dynamics in children receiving busulfan or treosulfan for haematopoietic stem cell transplant conditioning

British journal of clinical pharmacology, 2020-08, Vol.86 (8), p.1537-1549

2020

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Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors

Beyond Deterministic Models in Drug Discovery and Development

Pharmacokinetic Profiles Determine Optimal Combination Treatment Schedules in Computational Models of Drug Resistance

Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment

Population-Pharmacokinetic and Covariate Analysis of Lurbinectedin (PM01183), a New RNA Polymerase II Inhibitor, in Pooled Phase I/II Trials in Patients with Cancer

Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation

Optimal dynamic control approach in a multi-objective therapeutic scenario: Application to drug delivery in the treatment of prostate cancer

A systems pharmacology model for inflammatory bowel disease

Advanced Boolean modeling of biological networks applied to systems pharmacology

Machine Learning Analysis of Individual Tumor Lesions in Four Metastatic Colorectal Cancer Clinical Studies: Linking Tumor Heterogeneity to Overall Survival

Relevance of primary lesion location, tumour heterogeneity and genetic mutation demonstrated through tumour growth inhibition and overall survival modelling in metastatic colorectal cancer

Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice

The Role of Mathematical Models in Immuno-Oncology: Challenges and Future Perspectives

The Long Neglected Player: Modeling Tumor Uptake to Guide Optimal Dosing

Drug Exposure to Establish Pharmacokinetic–Response Relationships in Oncology

Physiologically-Based Pharmacokinetic model for Ciprofloxacin in children with complicated Urinary Tract Infection

Untangling Absorption Mechanisms and Variability in Bioequivalence Studies Using Population Analysis

Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-β kinase antagonist, in mice

Neoadjuvant therapy for locally advanced gastric cancer patients. A population pharmacodynamic modeling

Tramadol and O-Desmethyl Tramadol Clearance Maturation and Disposition in Humans: A Pooled Pharmacokinetic Study

Model-Based Meta-Analysis Supporting the Combination of Acetaminophen and Topical Diclofenac in Acute Pain: A Therapy for Mild-to-Moderate Osteoarthritis Pain?

Model-Based Assessment of the Liver Safety Profile of Acetaminophen to Support its Combination Use with Topical Diclofenac in Mild-to-Moderate Osteoarthritis Pain

Mechanistic modelling of enzyme‐restoration effects of new recombinant liver‐targeted proteins in acute intermittent porphyria

Modulation of intratumoural myeloid cells, the hallmark of the anti-tumour efficacy induced by a triple combination: tumour-associated peptide, TLR-3 ligand and α-PD-1

Modelling of neutrophil dynamics in children receiving busulfan or treosulfan for haematopoietic stem cell transplant conditioning

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