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Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.794-806

2007

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Characterization of (16 R) and (16 S)-hydroxyroquefortine C; diastereomeric metabolites from Penicillium crustosum DAOM 215343

Tetrahedron letters, 2012-02, Vol.53 (8), p.956-958

2012

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Synthesis and Reactivity of N-Hydroxy-2-Amino-3-Arylindoles

Synlett, 2007-12, Vol.2007 (19), p.2991-2994

2007

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Isolation and Structure Elucidation by LC-MS-SPE/NMR: PR Toxin- and Cuspidatol-Related Eremophilane Sesquiterpenes from Penicillium roqueforti

Journal of natural products (Washington, D.C.), 2007-01, Vol.70 (1), p.121-123

2007

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Identification of novel metabolites of colchicine in rat bile facilitated by enhanced online radiometric detection

Drug metabolism and disposition, 2008-04, Vol.36 (4), p.731

2008

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Diversity in the Oxidation of Substrates by Cytochrome P450 2D6: Lack of an Obligatory Role of Aspartate 301−Substrate Electrostatic Bonding

Biochemistry (Easton), 2002-09, Vol.41 (36), p.11025-11034

2002

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Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.527-530

2005

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In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites

Bioorganic & medicinal chemistry letters, 2007-01, Vol.17 (2), p.301-304

2007

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Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560

Journal of mass spectrometry., 2006-06, Vol.41 (6), p.771-780

2006

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In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663)

Bioorganic & medicinal chemistry letters, 2001-04, Vol.11 (8), p.1059-1062

2001

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Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx ™)

Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (23), p.2683-2686

2000

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Amination of chiral enolates by dialkyl azodiformates. Synthesis of .alpha.-hydrazino acids and .alpha.-amino acids

Journal of the American Chemical Society, 1986-10, Vol.108 (20), p.6397-6399

1986

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NMR structural studies of the tight complex between a trifluoromethyl ketone inhibitor and the 85-kDa human phospholipase A2

Biochemistry (Easton), 1993-11, Vol.32 (47), p.12560-12565

1993

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In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization

Drug metabolism and disposition, 2001-05, Vol.29 (5), p.638

2001

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Total Synthesis of (+)-Cyanthiwigin AC

Organic letters, 2006-11, Vol.8 (24), p.5585-5588

2006

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Discovery of a Potent and Selective Prostaglandin D 2 Receptor Antagonist, [(3 R )-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[ b ]indol-3-yl]-acetic Acid (MK-0524)

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.794-806

2007

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Studies on the Dimerization of 2-Benzylidene-1-indanone

Journal of organic chemistry, 1997-06, Vol.62 (13), p.4339-4342

1997

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Site Selectivity in the α-Silyl Lithiation of 3,4,6-Tris-O-(tert-butyldimethylsilyl)-d-glucal and 3,4-Bis-O-(tert-butyldimethylsilyl)- 6-deoxy-l-glucal with tert-Butyllithium

Journal of organic chemistry, 1996-02, Vol.61 (3), p.1165-1168

1996

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Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization

Drug metabolism and disposition, 2001-03, Vol.29 (3), p.232

2001

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Synthesis and reactivity of N-hydroxy-2-aminoindoles

Tetrahedron letters, 2006-01, Vol.47 (2), p.159-162

2006

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Oxidative bioactivation of the lactol prodrug of a lactone cyclooxygenase-2 inhibitor

Drug metabolism and disposition, 1999-03, Vol.27 (3), p.403

1999

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Discovery, Biosynthesis, and Structure Elucidation of Metabolites of a Doping Agent and a Direct Analogue, Tetrahydrogestrinone and Gestrinone, Using Human Hepatocytes

Analytical chemistry (Washington), 2005-05, Vol.77 (10), p.3164-3172

2005

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Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action

Molecular pharmacology, 2001-01, Vol.59 (1), p.144-152

2001

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Characterization of the in vitro oxidative metabolites of the COX-2 selective inhibitor L-766,112

Bioorganic & medicinal chemistry letters, 1997-01, Vol.7 (1), p.53-56

1997

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Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)

Characterization of (16 R) and (16 S)-hydroxyroquefortine C; diastereomeric metabolites from Penicillium crustosum DAOM 215343

Synthesis and Reactivity of N-Hydroxy-2-Amino-3-Arylindoles

Isolation and Structure Elucidation by LC-MS-SPE/NMR: PR Toxin- and Cuspidatol-Related Eremophilane Sesquiterpenes from Penicillium roqueforti

Identification of novel metabolites of colchicine in rat bile facilitated by enhanced online radiometric detection

Diversity in the Oxidation of Substrates by Cytochrome P450 2D6: Lack of an Obligatory Role of Aspartate 301−Substrate Electrostatic Bonding

Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites

Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560

In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663)

Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx ™)

Amination of chiral enolates by dialkyl azodiformates. Synthesis of .alpha.-hydrazino acids and .alpha.-amino acids

NMR structural studies of the tight complex between a trifluoromethyl ketone inhibitor and the 85-kDa human phospholipase A2

In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization

Total Synthesis of (+)-Cyanthiwigin AC

Discovery of a Potent and Selective Prostaglandin D 2 Receptor Antagonist, [(3 R )-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[ b ]indol-3-yl]-acetic Acid (MK-0524)

Studies on the Dimerization of 2-Benzylidene-1-indanone

Site Selectivity in the α-Silyl Lithiation of 3,4,6-Tris-O-(tert-butyldimethylsilyl)-d-glucal and 3,4-Bis-O-(tert-butyldimethylsilyl)- 6-deoxy-l-glucal with tert-Butyllithium

Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization

Synthesis and reactivity of N-hydroxy-2-aminoindoles

Oxidative bioactivation of the lactol prodrug of a lactone cyclooxygenase-2 inhibitor

Discovery, Biosynthesis, and Structure Elucidation of Metabolites of a Doping Agent and a Direct Analogue, Tetrahydrogestrinone and Gestrinone, Using Human Hepatocytes

Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action

Characterization of the in vitro oxidative metabolites of the COX-2 selective inhibitor L-766,112

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