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The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2

Inflammation research, 2002-03, Vol.51 (3), p.135-143

2002

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Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis

Journal of rheumatology, 2001-09, Vol.28 (9), p.2060

2001

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Antithrombotic and platelet function inhibiting effects of ML3000, a new antiinflammatory drug with Cox/5-LOX inhibitory activity

Inflammation research, 2002-03, Vol.51 (3), p.129-134

2002

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ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury

European journal of pharmacology, 1994-12, Vol.271 (2), p.525-531

1994

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Anti-inflammatory planar chiral [2.2]paracyclophaneacetic acid enantiomers

Inflammation research, 2001-07, Vol.50 (7), p.371-374

2001

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The Effects of ML 3000 on Antigen-induced Responses in Sheep

Pulmonary pharmacology & therapeutics, 1997-06, Vol.10 (3), p.167-173

1997

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The pharmacological profile of ML3000: A new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase

Inflammopharmacology, 2001-05, Vol.9 (1-2), p.113-124

2001

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The Influence of Oxidatively Modified Low Density Lipoprotein on Parameters of Energy Metabolism and Contractile Function of Arterial Smooth Muscle

Free radical research, 1991, Vol.11 (6), p.281-286

1991

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Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors

Journal of rheumatology, 2002-07, Vol.29 (7), p.1446

2002

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Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase

Arzneimittel-Forschung, 1994-05, Vol.44 (5), p.629

1994

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Studies on the in vitro and in vivo genotoxicity of [2,2-dimethyl-6- (4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid

Arzneimittel-Forschung, 1995-04, Vol.45 (4), p.486

1995

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Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid

Arzneimittel-Forschung, 1995-01, Vol.45 (1), p.27

1995

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Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl- 2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in the rat

Arzneimittel-Forschung, 1994-12, Vol.44 (12), p.1329

1994

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General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3- dihydro-1H-pyrrolizine-5-yl]-acetic acid in experimental animals

Arzneimittel-Forschung, 1995-02, Vol.45 (2), p.159

1995

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P59 Diarylpyrrolizines; dual inhibitors of CO and 5-LO

European journal of pharmaceutical sciences, 1994, Vol.2 (1), p.133-133

1994

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Synthesis and Evaluation of a Novel Series of Pyrrolizine Derivatives as Dual Cyclooxygenase-1 and 5-Lipoxygenase Inhibitors

Archiv der Pharmazie (Weinheim), 1997-10, Vol.330 (9-10), p.307-312

1997

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In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML‐3000 reduces the progression of experimental osteoarthritis: Suppression of collagenase 1 and interleukin‐1β synthesis

Arthritis and rheumatism, 2001-10, Vol.44 (10), p.2320-2330

2001

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Beeinflussung der aktiv mechanischen Eigenschaften von arteriellen Gefäßsegmenten durch oxidativ modifiziertes LDL

Arteriosklerose, 1990, p.292-295

1990

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Sexually transmitted infections in young people and factors associated with HIV coinfection: an observational study in a large city

BMJ open, 2019-05, Vol.9 (5), p.e027245

2019

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In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis

Arthritis and rheumatism, 2001-10, Vol.44 (10), p.2320-2330

2001

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ChemInform Abstract: Synthesis and Evaluation of a Novel Series of Pyrrolizine Derivatives (VII) as Dual Cyclooxygenase-1 and 5-Lipoxygenase Inhibitors

ChemInform, 1998-02, Vol.29 (5), p.no-no

1998

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Cefepime–Taniborbactam in Complicated Urinary Tract Infection

The New England journal of medicine, 2024-02, Vol.390 (7), p.611-622

2024

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Three randomized trials of maternal influenza immunization in Mali, Nepal, and South Africa: Methods and expectations

Vaccine, 2015-07, Vol.33 (32), p.3801-3812

2015

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Development of the All-Russian project "Regional Educational Schools of the Russian Society of Obstetricians and Gynecologists"

Obstetrics and gynecology: News, Opinions, Training, 2021, Vol.9 (1), p.69-73

2021

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DRINK OF THE GODS IN EVERYDAY AND HOLYDAY JAPANESE CULTURE

Vestnik Tomskogo gosudarstvennogo universiteta. Kul'turologiya i iskusstvovedenie, 2020-09 (39), p.22-32

Izotova, Nadezda N.

2020

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The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2

Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis

Antithrombotic and platelet function inhibiting effects of ML3000, a new antiinflammatory drug with Cox/5-LOX inhibitory activity

ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury

Anti-inflammatory planar chiral [2.2]paracyclophaneacetic acid enantiomers

The Effects of ML 3000 on Antigen-induced Responses in Sheep

The pharmacological profile of ML3000: A new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase

The Influence of Oxidatively Modified Low Density Lipoprotein on Parameters of Energy Metabolism and Contractile Function of Arterial Smooth Muscle

Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors

Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase

Studies on the in vitro and in vivo genotoxicity of [2,2-dimethyl-6- (4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid

Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid

Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl- 2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in the rat

General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3- dihydro-1H-pyrrolizine-5-yl]-acetic acid in experimental animals

P59 Diarylpyrrolizines; dual inhibitors of CO and 5-LO

Synthesis and Evaluation of a Novel Series of Pyrrolizine Derivatives as Dual Cyclooxygenase-1 and 5-Lipoxygenase Inhibitors

In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML‐3000 reduces the progression of experimental osteoarthritis: Suppression of collagenase 1 and interleukin‐1β synthesis

Beeinflussung der aktiv mechanischen Eigenschaften von arteriellen Gefäßsegmenten durch oxidativ modifiziertes LDL

Sexually transmitted infections in young people and factors associated with HIV coinfection: an observational study in a large city

In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis

ChemInform Abstract: Synthesis and Evaluation of a Novel Series of Pyrrolizine Derivatives (VII) as Dual Cyclooxygenase-1 and 5-Lipoxygenase Inhibitors

Cefepime–Taniborbactam in Complicated Urinary Tract Infection

Three randomized trials of maternal influenza immunization in Mali, Nepal, and South Africa: Methods and expectations

Development of the All-Russian project "Regional Educational Schools of the Russian Society of Obstetricians and Gynecologists"

DRINK OF THE GODS IN EVERYDAY AND HOLYDAY JAPANESE CULTURE

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