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Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

Journal of the American Chemical Society, 2003-04, Vol.125 (14), p.4087-4096

2003

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Fragment Screening and Assembly: A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor

Journal of medicinal chemistry, 2003-09, Vol.46 (20), p.4232-4235

2003

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Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice

Diabetes (New York, N.Y.), 2003-01, Vol.52 (1), p.21-28

2003

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Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis

Diabetes (New York, N.Y.), 2002-08, Vol.51 (8), p.2405-2411

2002

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Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line

Molecular and cellular endocrinology, 2002-09, Vol.195 (1), p.109-118

2002

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Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors

Journal of medicinal chemistry, 2006-07, Vol.49 (15), p.4455-4458

2006

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Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.668-672

2007

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c-Jun N-terminal kinase pathways in diabetes

The international journal of biochemistry & cell biology, 2008, Vol.40 (12), p.2702-2706

2008

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Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors

Biochemistry (Easton), 2006-06, Vol.45 (24), p.7474-7482

2006

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Identification of a monoacid-Based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.3947-3950

2003

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Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (10), p.2590-2594

2006

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Antisense Protein Tyrosine Phosphatase 1B Reverses Activation of p38 Mitogen-Activated Protein Kinase in Liver of ob/ob Mice

Molecular endocrinology (Baltimore, Md.), 2003-06, Vol.17 (6), p.1131-1143

2003

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Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells

Biochemical and biophysical research communications, 2003-01, Vol.300 (2), p.261-267

2003

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PTP1B Antisense Oligonucleotide Lowers PTP1B Protein, Normalizes Blood Glucose, and Improves Insulin Sensitivity in Diabetic Mice

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (17), p.11357-11362

2002

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Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity

Journal of medicinal chemistry, 2006-06, Vol.49 (12), p.3563-3580

2006

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Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors

Journal of medicinal chemistry, 2007-04, Vol.50 (8), p.1983-1987

2007

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Liver-specific Knockdown of JNK1 Up-regulates Proliferator-activated Receptor γ Coactivator 1β and Increases Plasma Triglyceride despite Reduced Glucose and Insulin Levels in Diet-induced Obese Mice

The Journal of biological chemistry, 2007-08, Vol.282 (31), p.22765-22774

2007

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Zotarolimus, a Novel Sirolimus Analogue With Potent Anti-proliferative Activity on Coronary Smooth Muscle Cells and Reduced Potential for Systemic Immunosuppression

Journal of cardiovascular pharmacology, 2007-04, Vol.49 (4), p.228-235

2007

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Pillars article: the CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. 1988

The Journal of immunology (1950), 2010-09, Vol.185 (5), p.2645-2649

2010

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T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC

Cellular immunology, 2002-05, Vol.217 (1), p.78-86

2002

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Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands

Journal of medicinal chemistry, 2003-07, Vol.46 (16), p.3437-3440

2003

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"The next big thing" in diabetes: clinical progress on DPP-IV inhibitors

Drug development research, 2006-08, Vol.67 (8), p.627-642

2006

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Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5543-5546

2004

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Discovery of 2-[4-{{2-(2S,5R)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279): A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes

Journal of medicinal chemistry, 2006-10, Vol.49 (21), p.6416-6420

2006

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Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

Fragment Screening and Assembly: A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor

Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice

Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis

Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line

Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors

Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies

c-Jun N-terminal kinase pathways in diabetes

Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors

Identification of a monoacid-Based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B

Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors

Antisense Protein Tyrosine Phosphatase 1B Reverses Activation of p38 Mitogen-Activated Protein Kinase in Liver of ob/ob Mice

Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells

PTP1B Antisense Oligonucleotide Lowers PTP1B Protein, Normalizes Blood Glucose, and Improves Insulin Sensitivity in Diabetic Mice

Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity

Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors

Liver-specific Knockdown of JNK1 Up-regulates Proliferator-activated Receptor γ Coactivator 1β and Increases Plasma Triglyceride despite Reduced Glucose and Insulin Levels in Diet-induced Obese Mice

Zotarolimus, a Novel Sirolimus Analogue With Potent Anti-proliferative Activity on Coronary Smooth Muscle Cells and Reduced Potential for Systemic Immunosuppression

Pillars article: the CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. 1988

T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC

Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands

"The next big thing" in diabetes: clinical progress on DPP-IV inhibitors

Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Discovery of 2-[4-{{2-(2S,5R)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279): A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes

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