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Mechanism and Function of Monoclonal Antibodies Targeting Siglec-15 for Therapeutic Inhibition of Osteoclastic Bone Resorption

The Journal of biological chemistry, 2014-03, Vol.289 (10), p.6498-6512

2014

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Abstract LB-091: Inhibition of Siglec-15 prevents bone loss in a mouse model of multiple myeloma

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.LB-091-LB-091

2016

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Ligand-Independent Recruitment of SRC-1 to Estrogen Receptor β through Phosphorylation of Activation Function AF-1

Molecular cell, 1999-04, Vol.3 (4), p.513-519

1999

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Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway

Bone (New York, N.Y.), 2008-01, Vol.42 (1), p.150-161

2008

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4-Hydroxytamoxifen Is an Isoform-Specific Inhibitor of Orphan Estrogen-Receptor-Related (ERR) Nuclear Receptors β and γ

Endocrinology (Philadelphia), 2001-10, Vol.142 (10), p.4572-4575

2001

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Dominant Activity of Activation Function 1 (AF-1) and Differential Stoichiometric Requirements for AF-1 and -2 in the Estrogen Receptor α-β Heterodimeric Complex

Molecular and Cellular Biology, 1999-03, Vol.19 (3), p.1919-1927

1999

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Synthesis and Evaluation of a Novel Nonsteroidal-Specific Endothelial Cell Proliferation Inhibitor

Journal of medicinal chemistry, 2003-04, Vol.46 (8), p.1289-1292

2003

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De Novo Design, Synthesis, and Evaluation of Novel Nonsteroidal Phenanthrene Ligands for the Estrogen Receptor

Journal of medicinal chemistry, 2003-04, Vol.46 (8), p.1408-1418

2003

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Coregulators of estrogen receptor action

Critical reviews in eukaryotic gene expression, 2002-01, Vol.12 (1), p.1

2002

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Abstract LB-297: The EMT inhibitor AB-16B5 interacts with specific isoforms of secreted clusterin

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.LB-297-LB-297

2012

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In vitro evaluation of the anti-estrogenic activity of hydroxyl substituted diphenylnaphthyl alkene ligands for the estrogen receptor

Bioorganic & medicinal chemistry, 2005-03, Vol.13 (5), p.1819-1828

2005

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A Polymorphic Autoregulatory Hormone Response Element in the Human Estrogen-related Receptor α (ERRα) Promoter Dictates Peroxisome Proliferator-activated Receptor γ Coactivator-1α Control of ERRα Expression

The Journal of biological chemistry, 2004-04, Vol.279 (18), p.18504-18510

2004

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De novo design, synthesis and evaluation of a non-steroidal diphenylnaphthyl propylene ligand for the estrogen receptor

Bioorganic & medicinal chemistry, 2003-04, Vol.11 (7), p.1389-1396

2003

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Coregulators of Estrogen Receptor Action

Critical reviews in eukaryotic gene expression, 2002, Vol.12 (1), p.22

2002

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Abstract 666: AB-3A4: A novel KAAG1-targeting antibody-drug conjugate is active in models of ovarian carcinoma, triple-negative breast cancer and castration-resistant prostate cancer

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.666-666

2014

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Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta

Genes & development, 2001-04, Vol.15 (7), p.833-838

2001

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Abstract LB-33: Pre-clinical evaluation of AB-16B5, a monoclonal antibody specific for tumor-associated sCLU, demonstrates therapeutic potential as an inhibitor of EMT in prostate, pancreatic and lung cancer

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.LB-33-LB-33

2011

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EM-800, a Novel Antiestrogen, Acts as a Pure Antagonist of the Transcriptional Functions of Estrogen Receptors α and β

Endocrinology (Philadelphia), 1998-01, Vol.139 (1), p.111-118

1998

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Estrogen Receptor β: Re-evaluation of Estrogen and Antiestrogen Signaling

Steroids, 1998-05, Vol.63 (5), p.335-339

1998

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Ligand-independent activation of the estrogen receptors α and β by mutations of a conserved tyrosine can be abolished by antiestrogens

Cancer research (Chicago, Ill.), 1998-03, Vol.58 (5), p.877-881

1998

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Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor β

Molecular endocrinology (Baltimore, Md.), 1997-03, Vol.11 (3), p.353-365

1997

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A polymorphic autoregulatory hormone response element in the human estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha expression

The Journal of biological chemistry, 2004-04, Vol.279 (18), p.18504-18510

2004

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A Polymorphic Autoregulatory Hormone Response Element in the Human Estrogen-related Receptor Î± (ERRÎ±) Promoter Dictates Peroxisome Proliferator-activated Receptor Î³ Coactivator-1Î± Control of ERRÎ± Expression

The Journal of biological chemistry, 2004-04, Vol.279 (18), p.18504

2004

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EM-800, a Novel Antiestrogen, Acts as a Pure Antagonist of the Transcriptional Functions of Estrogen Receptors α and β1

Endocrinology (Philadelphia), 1998-01, Vol.139 (1), p.111-118

1998

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NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is targeted to the cytoplasm in insect cell lines

FEBS letters, 1995-07, Vol.368 (1), p.177-182

1995

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Mechanism and Function of Monoclonal Antibodies Targeting Siglec-15 for Therapeutic Inhibition of Osteoclastic Bone Resorption

Abstract LB-091: Inhibition of Siglec-15 prevents bone loss in a mouse model of multiple myeloma

Ligand-Independent Recruitment of SRC-1 to Estrogen Receptor β through Phosphorylation of Activation Function AF-1

Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway

4-Hydroxytamoxifen Is an Isoform-Specific Inhibitor of Orphan Estrogen-Receptor-Related (ERR) Nuclear Receptors β and γ

Dominant Activity of Activation Function 1 (AF-1) and Differential Stoichiometric Requirements for AF-1 and -2 in the Estrogen Receptor α-β Heterodimeric Complex

Synthesis and Evaluation of a Novel Nonsteroidal-Specific Endothelial Cell Proliferation Inhibitor

De Novo Design, Synthesis, and Evaluation of Novel Nonsteroidal Phenanthrene Ligands for the Estrogen Receptor

Coregulators of estrogen receptor action

Abstract LB-297: The EMT inhibitor AB-16B5 interacts with specific isoforms of secreted clusterin

In vitro evaluation of the anti-estrogenic activity of hydroxyl substituted diphenylnaphthyl alkene ligands for the estrogen receptor

A Polymorphic Autoregulatory Hormone Response Element in the Human Estrogen-related Receptor α (ERRα) Promoter Dictates Peroxisome Proliferator-activated Receptor γ Coactivator-1α Control of ERRα Expression

De novo design, synthesis and evaluation of a non-steroidal diphenylnaphthyl propylene ligand for the estrogen receptor

Coregulators of Estrogen Receptor Action

Abstract 666: AB-3A4: A novel KAAG1-targeting antibody-drug conjugate is active in models of ovarian carcinoma, triple-negative breast cancer and castration-resistant prostate cancer

Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta

Abstract LB-33: Pre-clinical evaluation of AB-16B5, a monoclonal antibody specific for tumor-associated sCLU, demonstrates therapeutic potential as an inhibitor of EMT in prostate, pancreatic and lung cancer

EM-800, a Novel Antiestrogen, Acts as a Pure Antagonist of the Transcriptional Functions of Estrogen Receptors α and β

Estrogen Receptor β: Re-evaluation of Estrogen and Antiestrogen Signaling

Ligand-independent activation of the estrogen receptors α and β by mutations of a conserved tyrosine can be abolished by antiestrogens

Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor β

A polymorphic autoregulatory hormone response element in the human estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha expression

A Polymorphic Autoregulatory Hormone Response Element in the Human Estrogen-related Receptor Î± (ERRÎ±) Promoter Dictates Peroxisome Proliferator-activated Receptor Î³ Coactivator-1Î± Control of ERRÎ± Expression

EM-800, a Novel Antiestrogen, Acts as a Pure Antagonist of the Transcriptional Functions of Estrogen Receptors α and β1

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is targeted to the cytoplasm in insect cell lines

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