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Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes

The Journal of pharmacology and experimental therapeutics, 2019-07, Vol.370 (1), p.72

2019

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Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro–In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2795-2804

2017

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Validation of Human MDR1-MDCK and BCRP-MDCK Cell Lines to Improve the Prediction of Brain Penetration

Journal of pharmaceutical sciences, 2019-07, Vol.108 (7), p.2476-2483

2019

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Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance

Drug metabolism and disposition, 2018-07, Vol.46 (7), p.989-1000

2018

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The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

The Journal of pharmacology and experimental therapeutics, 2006-01, Vol.316 (1), p.336

2006

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Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey

Drug metabolism and disposition, 2018-08, Vol.46 (8), p.1179-1189

2018

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A novel relay method for determining low-clearance values

Drug metabolism and disposition, 2012-09, Vol.40 (9), p.1860

2012

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Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes

The AAPS journal, 2017-05, Vol.19 (3), p.787-796

2017

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In Vitro Evaluation of the Potential for Drug Interactions by Salidroside

Nutrients, 2023-08, Vol.15 (17), p.3723

2023

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Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study

Drug metabolism and disposition, 2005-02, Vol.33 (2), p.262

2005

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A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects

Drug metabolism and disposition, 2018-04, Vol.46 (4), p.357-366

2018

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Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Drug metabolism and disposition, 2012-03, Vol.40 (3), p.625

2012

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Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides

Drug metabolism and disposition, 2017-07, Vol.45 (7), p.721-733

2017

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A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects

Drug metabolism and disposition, 2018-04, Vol.46 (4), p.346-356

2018

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Estimation of Circulating Drug Metabolite Exposure in Human Using In Vitro Data and Physiologically Based Pharmacokinetic Modeling: Example of a High Metabolite/Parent Drug Ratio

Drug metabolism and disposition, 2018-02, Vol.46 (2), p.89-99

2018

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In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: Qualitative relationships, quantitative predictions, and the rank-order approach

Clinical pharmacology and therapeutics, 2005-12, Vol.78 (6), p.582-592

2005

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Prediction of drug-drug interactions from in vitro induction data: application of the relative induction score approach using cryopreserved human hepatocytes

Drug metabolism and disposition, 2008-09, Vol.36 (9), p.1971

2008

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The role of ADME pharmacogenomics in early clinical trials: perspective of the Industry Pharmacogenomics Working Group (I-PWG)

Pharmacogenomics, 2015-12, Vol.16 (18), p.2055-2067

2015

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Tissue distribution and elimination of [14C]apixaban in rats

Drug metabolism and disposition, 2011-02, Vol.39 (2), p.256

2011

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Simultaneous assessment of transporter drug–drug interactions using a probe drug cocktail in cynomolgus monkey

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S77-S77

2019

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P110 - The phenotyping of solute carrier transporters in human primary hepatocytes: A chemical inhibition approach

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S55-S56

2020

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P-glycoprotein has differential effects on the disposition of statin acid and lactone forms in mdr1a/b knockout and wild-type mice

Drug metabolism and disposition, 2007-10, Vol.35 (10), p.1725

2007

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Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG

Pharmacogenomics, 2016-04, Vol.17 (6), p.615-631

2016

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Unbound tissue exposure (Kpuu) of oatps substrates in the cynomolgus monkey

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S105-S105

2017

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The phenotyping of solute carrier transporters in human primary hepatocytes

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S71-S71

2019

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Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes

Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro–In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs

Validation of Human MDR1-MDCK and BCRP-MDCK Cell Lines to Improve the Prediction of Brain Penetration

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey

A novel relay method for determining low-clearance values

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes

In Vitro Evaluation of the Potential for Drug Interactions by Salidroside

Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects

Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects

Estimation of Circulating Drug Metabolite Exposure in Human Using In Vitro Data and Physiologically Based Pharmacokinetic Modeling: Example of a High Metabolite/Parent Drug Ratio

In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: Qualitative relationships, quantitative predictions, and the rank-order approach

Prediction of drug-drug interactions from in vitro induction data: application of the relative induction score approach using cryopreserved human hepatocytes

The role of ADME pharmacogenomics in early clinical trials: perspective of the Industry Pharmacogenomics Working Group (I-PWG)

Tissue distribution and elimination of [14C]apixaban in rats

Simultaneous assessment of transporter drug–drug interactions using a probe drug cocktail in cynomolgus monkey

P110 - The phenotyping of solute carrier transporters in human primary hepatocytes: A chemical inhibition approach

P-glycoprotein has differential effects on the disposition of statin acid and lactone forms in mdr1a/b knockout and wild-type mice

Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG

Unbound tissue exposure (Kpuu) of oatps substrates in the cynomolgus monkey

The phenotyping of solute carrier transporters in human primary hepatocytes

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