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Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

BMC genomics, 2011-06, Vol.12 (1), p.281-281, Article 281

2011

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Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R,S]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide)

The Journal of pharmacology and experimental therapeutics, 2007-04, Vol.321 (1), p.45

2007

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The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis

The Journal of pharmacology and experimental therapeutics, 2010-04, Vol.333 (1), p.2

2010

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Modeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platform

PloS one, 2011-11, Vol.6 (11), p.e27009-e27009

2011

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Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors

Drug metabolism and disposition, 2007-03, Vol.35 (3), p.493

2007

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cis-2,5-Dicyanopyrrolidine Inhibitors of Dipeptidyl Peptidase IV: Synthesis and in Vitro, in Vivo, and X-ray Crystallographic Characterization

Journal of medicinal chemistry, 2006-06, Vol.49 (11), p.3068-3076

2006

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Establishment of correlation between in vitro enzyme binding potency and in vivo pharmacological activity: application to liver glycogen phosphorylase a inhibitors

The Journal of pharmacology and experimental therapeutics, 2006-06, Vol.317 (3), p.1230

2006

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Islet-selectivity of G-protein coupled receptor ligands evaluated for PET imaging of pancreatic β-cell mass

Biochemical and biophysical research communications, 2011-09, Vol.412 (3), p.413-418

2011

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Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets : Role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia

Diabetes (New York, N.Y.), 2005-05, Vol.54 (5), p.1552-1558

2005

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Defective Glycogenesis Contributes Toward the Inability to Suppress Hepatic Glucose Production in Response to Hyperglycemia and Hyperinsulinemia in Zucker Diabetic Fatty Rats

Diabetes (New York, N.Y.), 2011-09, Vol.60 (9), p.2225-2233

2011

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Pancreatic Beta Cell Mass PET Imaging and Quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in Rodent Models of Diabetes

Molecular imaging and biology, 2011-10, Vol.13 (5), p.973-984

2011

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Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs

The Journal of pharmacology and experimental therapeutics, 2011-06, Vol.337 (3), p.610

2011

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Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase

Journal of lipid research, 2005-03, Vol.46 (3), p.547-563

2005

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The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drug

FEBS letters, 2007-10, Vol.581 (24), p.4749-4753

2007

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3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (7), p.1991-1995

2009

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1-((3 S,4 S)-4-Amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1810-1814

2011

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Anilinoquinazoline Inhibitors of Fructose 1,6-Bisphosphatase Bind at a Novel Allosteric Site: Synthesis, In Vitro Characterization, and X-ray Crystallography

Journal of medicinal chemistry, 2002-08, Vol.45 (18), p.3865-3877

2002

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Cardioprotective effects of ingliforib, a novel glycogen phosphorylase inhibitor

American journal of physiology. Heart and circulatory physiology, 2004-03, Vol.286 (3), p.H1177-H1184

2004

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Indole-2-carboxamide Inhibitors of Human Liver Glycogen Phosphorylase

Journal of medicinal chemistry, 1998-07, Vol.41 (16), p.2934-2938

1998

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5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization

Applied catalysis. B, Environmental, 2005-01, Vol.15 (2), p.459-465

2005

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Integrated effects of multiple modulators on human liver glycogen phosphorylase a

American journal of physiology: endocrinology and metabolism, 2002-07, Vol.283 (1), p.E29-E37

2002

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3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: An allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (12), p.2055-2058

2003

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(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: Synthesis, in vitro, in vivo, and X-ray crystallographic characterization

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5638-5642

2007

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Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors

American journal of physiology: endocrinology and metabolism, 2005-09, Vol.289 (3), p.E366-E372

2005

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Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes

Diabetes (New York, N.Y.), 2000-12, Vol.49 (12), p.2079-2086

2000

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Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R,S]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide)

The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis

Modeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platform

Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors

cis-2,5-Dicyanopyrrolidine Inhibitors of Dipeptidyl Peptidase IV: Synthesis and in Vitro, in Vivo, and X-ray Crystallographic Characterization

Establishment of correlation between in vitro enzyme binding potency and in vivo pharmacological activity: application to liver glycogen phosphorylase a inhibitors

Islet-selectivity of G-protein coupled receptor ligands evaluated for PET imaging of pancreatic β-cell mass

Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets : Role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia

Defective Glycogenesis Contributes Toward the Inability to Suppress Hepatic Glucose Production in Response to Hyperglycemia and Hyperinsulinemia in Zucker Diabetic Fatty Rats

Pancreatic Beta Cell Mass PET Imaging and Quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in Rodent Models of Diabetes

Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs

Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase

The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drug

3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor

1-((3 S,4 S)-4-Amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes

Anilinoquinazoline Inhibitors of Fructose 1,6-Bisphosphatase Bind at a Novel Allosteric Site: Synthesis, In Vitro Characterization, and X-ray Crystallography

Cardioprotective effects of ingliforib, a novel glycogen phosphorylase inhibitor

Indole-2-carboxamide Inhibitors of Human Liver Glycogen Phosphorylase

5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization

Integrated effects of multiple modulators on human liver glycogen phosphorylase a

3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: An allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site

(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: Synthesis, in vitro, in vivo, and X-ray crystallographic characterization

Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors

Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes

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