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Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2428-2436

2019

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Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi® and Epclusa

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2415-2427

2019

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Efficient photocatalysis of organic dyes under simulated sunlight irradiation by a novel magnetic CuFe2O4@porphyrin nanofiber hybrid material fabricated via self-assembly

Fuel (Guildford), 2020-12, Vol.281, p.118655, Article 118655

2020

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Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (22), p.6404-6412

2009

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Pyrrolo[1,2- b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (12), p.3616-3621

2008

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1' -dioxo-1' 4'-dihydro-1 λ6-benzoll 1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7'-substitution of benzothiadiazine

Bioorganic & medicinal chemistry letters, 2008-02, Vol.18 (4), p.1413-1418

2008

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Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[ b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.4181-4185

2008

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1' ,4'-dihydro-1 λ6-benzoll[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2-and 6-pyridazinone substituents

Bioorganic & medicinal chemistry letters, 2008-02, Vol.18 (4), p.1419-1424

2008

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'λ6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5. Exploration of pyridazinones containing 6-amino-substituents

Bioorganic & medicinal chemistry letters, 2008-10, Vol.18 (20), p.5635-5639

2008

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5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.451-458

2009

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5,5'- and 6,6'-Dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (21), p.6047-6052

2009

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4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2008-08, Vol.18 (16), p.4628-4632

2008

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Efficient Large-Scale Synthesis of 2-Amino-5-methanesulfonylaminobenzenesulfonamide

Synthetic communications, 2008-05, Vol.38 (12), p.1909-1916

2008

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Synthesis of New Pyridazinone Derivatives: 2,6-Disubstituted 5-Hydroxy-3(2H)-pyridazinone-4-carboxylic Acid Ethyl Esters

Synthesis (Stuttgart), 2007-11, Vol.2007 (21), p.3301-3308

2007

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Efficient synthesis of (1 R,2 S) and (1 S,2 R)-2-aminocyclopentanecarboxylic acid ethyl ester derivatives in enantiomerically pure form

Tetrahedron: asymmetry, 2008-12, Vol.19 (24), p.2796-2803

2008

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5,6-Dihydro-lH-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.451-458

2009

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5,6-Dihydro-1 H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.451-458

2009

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5,5′- and 6,6′-Dialkyl-5,6-dihydro-1 H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (21), p.6047-6052

2009

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4-(1,1-Dioxo-1,4-dihydro-1 lambda super(6)-benzo[1,4]thiazin-3-yl)-5-hydroxy- 2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (16), p.4628-4632

2008

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Discovery of tricyclic 5,6-dihydro-1 H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (22), p.6404-6412

2009

Volltextzugriff (PDF)

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ 6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2 H-pyridazin-3-ones. Part 1: Exploration of 7′-substitution of benzothiadiazine

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (4), p.1413-1418

2008

Volltextzugriff (PDF)

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ 6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2 H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (20), p.5635-5639

2008

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Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi

Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi® and Epclusa

Efficient photocatalysis of organic dyes under simulated sunlight irradiation by a novel magnetic CuFe2O4@porphyrin nanofiber hybrid material fabricated via self-assembly

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Pyrrolo[1,2- b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1' -dioxo-1' 4'-dihydro-1 λ6-benzoll 1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7'-substitution of benzothiadiazine

Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[ b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1' ,4'-dihydro-1 λ6-benzoll[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2-and 6-pyridazinone substituents

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'λ6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5. Exploration of pyridazinones containing 6-amino-substituents

5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

5,5'- and 6,6'-Dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments

Efficient Large-Scale Synthesis of 2-Amino-5-methanesulfonylaminobenzenesulfonamide

Synthesis of New Pyridazinone Derivatives: 2,6-Disubstituted 5-Hydroxy-3(2H)-pyridazinone-4-carboxylic Acid Ethyl Esters

Efficient synthesis of (1 R,2 S) and (1 S,2 R)-2-aminocyclopentanecarboxylic acid ethyl ester derivatives in enantiomerically pure form

5,6-Dihydro-lH-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

5,6-Dihydro-1 H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

5,5′- and 6,6′-Dialkyl-5,6-dihydro-1 H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

4-(1,1-Dioxo-1,4-dihydro-1 lambda super(6)-benzo[1,4]thiazin-3-yl)-5-hydroxy- 2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase

Discovery of tricyclic 5,6-dihydro-1 H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ 6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2 H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ 6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2 H-pyridazin-3-ones. Part 1: Exploration of 7′-substitution of benzothiadiazine

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ 6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2 H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents

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