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Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450

Drug metabolism and disposition, 1999-12, Vol.27 (12), p.1488

1999

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Topiramate and Phenytoin Pharmacokinetics During Repetitive Monotherapy and Combination Therapy to Epileptic Patients

Epilepsia (Copenhagen), 2002-07, Vol.43 (7), p.691-696

2002

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Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

Chemical research in toxicology, 1992-01, Vol.5 (1), p.54-59

1992

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Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies

Drug metabolism and disposition, 1996-04, Vol.24 (4), p.414

1996

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Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients

The Journal of pharmacology and experimental therapeutics, 1994-10, Vol.271 (1), p.549

1994

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Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen

Drug metabolism and disposition, 1997-12, Vol.25 (12), p.1407

1997

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Warfarin-fluconazole. II. A metabolically based drug interaction: in vivo studies

Drug metabolism and disposition, 1996-04, Vol.24 (4), p.422

1996

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Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline

Chemical research in toxicology, 1993-09, Vol.6 (5), p.649-656

1993

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Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation

The Journal of pharmacology and experimental therapeutics, 1994-10, Vol.271 (1), p.557

1994

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The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity

Drug metabolism and disposition, 2003-12, Vol.31 (12), p.1481-1497

2003

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Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19

Drug metabolism and disposition, 1996-05, Vol.24 (5), p.610

1996

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Three-dimensional quantitative structure-activity relationship for inhibitors of cytochrome P4502C9

Drug metabolism and disposition, 1996-01, Vol.24 (1), p.1

1996

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A Refined 3-Dimensional QSAR of Cytochrome P450 2C9: Computational Predictions of Drug Interactions

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2789-2796

2000

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Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: In vitro and in vivo comparison and calculation of in vivo inhibition constants

Clinical pharmacology and therapeutics, 1997-11, Vol.62 (5), p.490-504

1997

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Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism

Drug metabolism and disposition, 1995-04, Vol.23 (4), p.490

1995

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(R)-(+)-Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 2A6

Drug metabolism and disposition, 1998-07, Vol.26 (7), p.701

1998

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Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species difference

Drug metabolism and disposition, 1993-09, Vol.21 (5), p.874

1993

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Active Site Characteristics of CYP4B1 Probed with Aromatic Ligands

Biochemistry (Easton), 2001-07, Vol.40 (29), p.8597-8605

2001

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Oxidation of Acetaminophen to Its Toxic Quinone Imine and Nontoxic Catechol Metabolites by Baculovirus-Expressed and Purified Human Cytochromes P450 2E1 and 2A6

Chemical research in toxicology, 1998-04, Vol.11 (4), p.295-301

1998

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Inhibition of (S)-warfarin metabolism by sulfinpyrazone and its metabolites

Drug metabolism and disposition, 1995-06, Vol.23 (6), p.659

1995

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Mechanism-Based Inactivation of P450 2A6 by Furanocoumarins

Biochemistry (Easton), 1998-07, Vol.37 (28), p.10047-10061

1998

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Characteristics of warfarin hydroxylation catalyzed by human liver microsomes

Drug metabolism and disposition, 1989-05, Vol.17 (3), p.265

1989

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Mechanism-Based Inactivation of Cytochrome P450 2B1 by 8-Methoxypsoralen and Several Other Furanocoumarins

Biochemistry (Easton), 1998-09, Vol.37 (38), p.13184-13193

1998

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Allelic Variants of Human Cytochrome P450 2C9: Baculovirus-Mediated Expression, Purification, Structural Characterization, Substrate Stereoselectivity, and Prochiral Selectivity of the Wild-Type and I359L Mutant Forms

Archives of biochemistry and biophysics, 1996-09, Vol.333 (2), p.447-458

1996

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Mechanisms of the stereoselective interaction between miconazole and racemic warfarin in human subjects

Clinical pharmacology and therapeutics, 1992-06, Vol.51 (6), p.656-667

1992

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Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450

Topiramate and Phenytoin Pharmacokinetics During Repetitive Monotherapy and Combination Therapy to Epileptic Patients

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies

Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients

Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen

Warfarin-fluconazole. II. A metabolically based drug interaction: in vivo studies

Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline

Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation

The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity

Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19

Three-dimensional quantitative structure-activity relationship for inhibitors of cytochrome P4502C9

A Refined 3-Dimensional QSAR of Cytochrome P450 2C9: Computational Predictions of Drug Interactions

Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: In vitro and in vivo comparison and calculation of in vivo inhibition constants

Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism

(R)-(+)-Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 2A6

Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species difference

Active Site Characteristics of CYP4B1 Probed with Aromatic Ligands

Oxidation of Acetaminophen to Its Toxic Quinone Imine and Nontoxic Catechol Metabolites by Baculovirus-Expressed and Purified Human Cytochromes P450 2E1 and 2A6

Inhibition of (S)-warfarin metabolism by sulfinpyrazone and its metabolites

Mechanism-Based Inactivation of P450 2A6 by Furanocoumarins

Characteristics of warfarin hydroxylation catalyzed by human liver microsomes

Mechanism-Based Inactivation of Cytochrome P450 2B1 by 8-Methoxypsoralen and Several Other Furanocoumarins

Allelic Variants of Human Cytochrome P450 2C9: Baculovirus-Mediated Expression, Purification, Structural Characterization, Substrate Stereoselectivity, and Prochiral Selectivity of the Wild-Type and I359L Mutant Forms

Mechanisms of the stereoselective interaction between miconazole and racemic warfarin in human subjects

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