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Therapy of experimental NASH and fibrosis with galectin inhibitors

PloS one, 2013-12, Vol.8 (12), p.e83481

2013

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Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease

PloS one, 2013-10, Vol.8 (10), p.e75361

2013

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Utility and variability of three non-invasive liver fibrosis imaging modalities to evaluate efficacy of GR-MD-02 in subjects with NASH and bridging fibrosis during a phase-2 randomized clinical trial

PloS one, 2018-09, Vol.13 (9), p.e0203054-e0203054

2018

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Binding of polysaccharides to human galectin-3 at a noncanonical site in its carbohydrate recognition domain

Glycobiology (Oxford), 2016-01, Vol.26 (1), p.88-99

2016

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Galectin-3 inhibition with belapectin combined with anti-OX40 therapy reprograms the tumor microenvironment to favor anti-tumor immunity

Oncoimmunology, 2021-01, Vol.10 (1), p.1892265-1892265

2021

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Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor

Journal for immunotherapy of cancer, 2021-04, Vol.9 (4), p.e002371

2021

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Phase 2 Dose-Finding Study in Patients with Gout Using SEL-212, a Novel PEGylated Uricase (SEL-037) Combined with Tolerogenic Nanoparticles (SEL-110)

Rheumatology and therapy., 2023-08, Vol.10 (4), p.825-847

2023

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Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension

Gastroenterology (New York, N.Y. 1943), 2020-04, Vol.158 (5), p.1334-1345.e5

2020

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The COMPARE head-to-head, randomized controlled trial of SEL-212 (pegadricase plus rapamycin-containing nanoparticle, ImmTOR™) versus pegloticase for refractory gout

Rheumatology (Oxford, England), 2024-04, Vol.63 (4), p.1058-1067

2024

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Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease

Journal of autoimmunity, 2023-11, Vol.140, p.103125-103125, Article 103125

2023

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Cdx1 and Cdx2 expression during intestinal development

Gastroenterology (New York, N.Y. 1943), 2000-10, Vol.119 (4), p.961-971

2000

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Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates Its transactivation capacity

Gastroenterology (New York, N.Y. 1943), 2001-12, Vol.121 (6), p.1437-1450

2001

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DNA Methylation Down-regulates CDX1 Gene Expression in Colorectal Cancer Cell Lines

The Journal of biological chemistry, 2002-09, Vol.277 (39), p.35795-35800

2002

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An intestine-specific homeobox gene regulates proliferation and differentiation

Molecular and Cellular Biology, 1996-02, Vol.16 (2), p.619-625

1996

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A Novel Colonic Repressor Element Regulates Intestinal Gene Expression by Interacting with Cux/CDP

Molecular and Cellular Biology, 2002-08, Vol.22 (15), p.5467-5478

2002

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Sa1686 Galectin-3 (Gal-3) Expression in Relation to Fibrosis in Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH)

Gastroenterology (New York, N.Y. 1943), 2014-05, Vol.146 (5), p.S-951-S-951

2014

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P084 Gout symptom improvements and patient outcomes with SEL-212 in gout refractory to conventional therapy: DISSOLVE I & II phase 3, double-blind, placebo-controlled clinical trials

Rheumatology (Oxford, England), 2024-04, Vol.63 (Supplement_1)

2024

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Surviving Hurricane Katrina: reconstructing the educational enterprise of Tulane University School of Medicine

Academic medicine, 2007-08, Vol.82 (8), p.757-762

2007

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The Caudal-related Homeodomain Protein Cdx1 Inhibits Proliferation of Intestinal Epithelial Cells by Down-regulation of D-type Cyclins

The Journal of biological chemistry, 2000-02, Vol.275 (6), p.4499-4506

2000

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The Down Regulated in Adenoma (dra) Gene Encodes an Intestine-specific Membrane Sulfate Transport Protein

The Journal of biological chemistry, 1995-05, Vol.270 (20), p.11897-11902

1995

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Clusterin gene transcription is activated by caudal-related homeobox genes in intestinal epithelium

American journal of physiology: Gastrointestinal and liver physiology, 2001-01, Vol.280 (1), p.G149-G156

2001

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Regulation of sucrase-isomaltase gene expression along the crypt-villus axis of rat small intestine

Biochemical and biophysical research communications, 1990-12, Vol.173 (3), p.765-773

Traber, Peter G.

1990

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Induction of cytochrome P450IA genes (CYP1A) by omeprazole in the human alimentary tract

Gastroenterology (New York, N.Y. 1943), 1992-11, Vol.103 (5), p.1509-1516

1992

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Tu1283 PRECLINICAL CHARACTERIZATION OF AN ORAL SMALL MOLECULE INHIBITOR TARGETING THE INTEGRIN α4β7 FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES (IBD)

Gastroenterology (New York, N.Y. 1943), 2020-05, Vol.158 (6), p.S-1043-S-1043

2020

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Developmental expression of SI is regulated in transgenic mice by an evolutionarily conserved promoter

American journal of physiology: Gastrointestinal and liver physiology, 1997-07, Vol.273 (1 Pt 1), p.G83-G92

1997

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Therapy of experimental NASH and fibrosis with galectin inhibitors

Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease

Utility and variability of three non-invasive liver fibrosis imaging modalities to evaluate efficacy of GR-MD-02 in subjects with NASH and bridging fibrosis during a phase-2 randomized clinical trial

Binding of polysaccharides to human galectin-3 at a noncanonical site in its carbohydrate recognition domain

Galectin-3 inhibition with belapectin combined with anti-OX40 therapy reprograms the tumor microenvironment to favor anti-tumor immunity

Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor

Phase 2 Dose-Finding Study in Patients with Gout Using SEL-212, a Novel PEGylated Uricase (SEL-037) Combined with Tolerogenic Nanoparticles (SEL-110)

Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension

The COMPARE head-to-head, randomized controlled trial of SEL-212 (pegadricase plus rapamycin-containing nanoparticle, ImmTOR™) versus pegloticase for refractory gout

Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease

Cdx1 and Cdx2 expression during intestinal development

Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates Its transactivation capacity

DNA Methylation Down-regulates CDX1 Gene Expression in Colorectal Cancer Cell Lines

An intestine-specific homeobox gene regulates proliferation and differentiation

A Novel Colonic Repressor Element Regulates Intestinal Gene Expression by Interacting with Cux/CDP

Sa1686 Galectin-3 (Gal-3) Expression in Relation to Fibrosis in Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH)

P084 Gout symptom improvements and patient outcomes with SEL-212 in gout refractory to conventional therapy: DISSOLVE I & II phase 3, double-blind, placebo-controlled clinical trials

Surviving Hurricane Katrina: reconstructing the educational enterprise of Tulane University School of Medicine

The Caudal-related Homeodomain Protein Cdx1 Inhibits Proliferation of Intestinal Epithelial Cells by Down-regulation of D-type Cyclins

The Down Regulated in Adenoma (dra) Gene Encodes an Intestine-specific Membrane Sulfate Transport Protein

Clusterin gene transcription is activated by caudal-related homeobox genes in intestinal epithelium

Regulation of sucrase-isomaltase gene expression along the crypt-villus axis of rat small intestine

Induction of cytochrome P450IA genes (CYP1A) by omeprazole in the human alimentary tract

Tu1283 PRECLINICAL CHARACTERIZATION OF AN ORAL SMALL MOLECULE INHIBITOR TARGETING THE INTEGRIN α4β7 FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES (IBD)

Developmental expression of SI is regulated in transgenic mice by an evolutionarily conserved promoter

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