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Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia

Molecular cell, 2014-01, Vol.53 (2), p.247-261

2014

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High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction

Journal of the American Chemical Society, 2013-01, Vol.135 (2), p.669-682

2013

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Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)–Mixed Lineage Leukemia (MLL) Protein–Protein Interaction

Journal of medicinal chemistry, 2017-06, Vol.60 (12), p.4818-4839

2017

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Key aspects of papillomavirus infection influence the host cervicovaginal microbiome in a preclinical murine papillomavirus (MmuPV1) infection model

mBio, 2024-05, Vol.15 (6), p.e0093324-e0093324

2024

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The dynamic balance of the skin microbiome across the lifespan

Biochemical Society transactions, 2023-02, Vol.51 (1), p.71

2023

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Longitudinal multi-omics analyses of the gut-liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis

Nature microbiology, 2023-01, Vol.8 (1), p.12

2023

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Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Nature (London), 2017-10, Vol.550 (7677), p.481

2017

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Discovery of a Novel Simian Pegivirus in Common Marmosets (Callithrix jacchus) with Lymphocytic Enterocolitis

Microorganisms (Basel), 2020-09, Vol.8 (10), p.1509

2020

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Analysis of the Binding of Mixed Lineage Leukemia 1 (MLL1) and Histone 3 Peptides to WD Repeat Domain 5 (WDR5) for the Design of Inhibitors of the MLL1−WDR5 Interaction

Journal of medicinal chemistry, 2010-07, Vol.53 (14), p.5179-5185

2010

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Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia

Cell reports (Cambridge), 2015-06, Vol.11 (9), p.1446-1457

2015

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What is slough? Defining the proteomic and microbial composition of slough and its implications for wound healing

Wound repair and regeneration, 2024-04

2024

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The porcine skin microbiome exhibits broad fungal antagonism

Fungal genetics and biology, 2024-08, Vol.173, p.103898-103898, Article 103898

2024

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The balance of type 1 and type 2 immune responses in the contexts of hepatitis B infection and hepatitis D infection

Journal of gastroenterology and hepatology, 2019-04, Vol.34 (4), p.764-775

2019

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Exploring the Link Between Platelet Numbers and Vascular Homeostasis Across Early and Late Stages of Fibrosis in Hepatitis C

Digestive diseases and sciences, 2020-02, Vol.65 (2), p.524-533

2020

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Microbial Translocation in the Context of Hepatitis B Infection and Hepatitis D Infection

Open forum infectious diseases, 2021-11, Vol.8 (11), p.ofaa496-ofaa496

2021

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Bacterial Translocation and Host Immune Activation in Chronic Hepatitis C Infection

Open forum infectious diseases, 2019-07, Vol.6 (7)

2019

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Tu1547 STATIN USE IS ASSOCIATED WITH A LOWER RISK OF HCC RECURRENCE AFTER RADIOFREQUENCY ABLATION IN PATIENTS WITH HCC

Gastroenterology (New York, N.Y. 1943), 2024-05, Vol.166 (5), p.S-1724-S-1724

2024

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Abstract LB-256: Targeting MLL1 methyltransferase activity for treatment of acute leukemia with MLL1 rearrangement

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.LB-256-LB-256

2012

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Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLL1-WDR5 protein–protein interaction as inhibitors of the MLL1 methyltransferase activity

Chinese chemical letters, 2015-04, Vol.26 (4), p.455-458

2015

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Targeting MLL1 H3 K4 methyltransferase activity in MLL leukemia

Molecular cell, 2014-01, Vol.53 (2), p.247-261

2014

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Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLLI-WDR5 protein-protein interaction as inhibitors of the MLL1 methyltransferase activity

中国化学快报：英文版, 2015 (4), p.455-458

Hacer Karatas Shirley Y. Lee Elizabeth C. Townsend Fang Cao Jing xu Denzil Bernard Liu Liu Yali Dou Shaomeng Wang

2015

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Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia

High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction

Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)–Mixed Lineage Leukemia (MLL) Protein–Protein Interaction

Key aspects of papillomavirus infection influence the host cervicovaginal microbiome in a preclinical murine papillomavirus (MmuPV1) infection model

The dynamic balance of the skin microbiome across the lifespan

Longitudinal multi-omics analyses of the gut-liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Discovery of a Novel Simian Pegivirus in Common Marmosets (Callithrix jacchus) with Lymphocytic Enterocolitis

Analysis of the Binding of Mixed Lineage Leukemia 1 (MLL1) and Histone 3 Peptides to WD Repeat Domain 5 (WDR5) for the Design of Inhibitors of the MLL1−WDR5 Interaction

Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia

What is slough? Defining the proteomic and microbial composition of slough and its implications for wound healing

The porcine skin microbiome exhibits broad fungal antagonism

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

The balance of type 1 and type 2 immune responses in the contexts of hepatitis B infection and hepatitis D infection

Exploring the Link Between Platelet Numbers and Vascular Homeostasis Across Early and Late Stages of Fibrosis in Hepatitis C

Microbial Translocation in the Context of Hepatitis B Infection and Hepatitis D Infection

Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia

Bacterial Translocation and Host Immune Activation in Chronic Hepatitis C Infection

Tu1547 STATIN USE IS ASSOCIATED WITH A LOWER RISK OF HCC RECURRENCE AFTER RADIOFREQUENCY ABLATION IN PATIENTS WITH HCC

The MDM2 Inhibitor NVP-CGM097 Is Highly Active in a Randomized Preclinical Trial of B-Cell Acute Lymphoblastic Leukemia Patient Derived Xenografts

Abstract LB-256: Targeting MLL1 methyltransferase activity for treatment of acute leukemia with MLL1 rearrangement

Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLL1-WDR5 protein–protein interaction as inhibitors of the MLL1 methyltransferase activity

Targeting MLL1 H3 K4 methyltransferase activity in MLL leukemia

Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLLI-WDR5 protein-protein interaction as inhibitors of the MLL1 methyltransferase activity

Co-activation of AMPK and mTORC1 Induce Cytotoxicity in Acute Myeloid Leukemia

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