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Inflammation, Infection and Venous Thromboembolism

Circulation research, 2021-06, Vol.128 (12), p.2017-2036

2021

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Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy

Trends in pharmacological sciences (Regular ed.), 2017-11, Vol.38 (11), p.1006-1015

2017

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15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5[S]

Journal of lipid research, 2020-07, Vol.61 (7), p.1087-1103

2020

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ENTPD-1 disrupts inflammasome IL-1β–driven venous thrombosis

The Journal of clinical investigation, 2019-07, Vol.129 (7), p.2872-2877

2019

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The emerging role of oxylipins in thrombosis and diabetes

Frontiers in pharmacology, 2014-01, Vol.4, p.176-176

2014

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Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race

Blood, 2014-11, Vol.124 (23), p.3450-3458

2014

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Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics

Arteriosclerosis, thrombosis, and vascular biology, 2018-07, Vol.38 (7), p.1632-1643

2018

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5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1

Biochemistry (Easton), 2018-12, Vol.57 (48), p.6726-6734

2018

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Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis

Arteriosclerosis, thrombosis, and vascular biology, 2014-12, Vol.34 (12), p.2644-2650

2014

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First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis

Arteriosclerosis, thrombosis, and vascular biology, 2017-10, Vol.37 (10), p.1828-1839

2017

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5S,15S‑Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5‑Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase‑1

Biochemistry (Easton), 2018-12, Vol.57 (48), p.6726-6734

2018

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12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-γ-Linolenic Acid, Inhibits Thrombosis via Gαs Signaling in Platelets

Arteriosclerosis, thrombosis, and vascular biology, 2016-10, Vol.36 (10), p.2068-2077

2016

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Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators

Biochemistry (Easton), 2020-05, Vol.59 (19), p.1832-1844

2020

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Role of Human 15-Lipoxygenase‑2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase‑1

Biochemistry (Easton), 2020-10, Vol.59 (42), p.4118-4130

2020

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B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia

Blood, 2014-02, Vol.123 (6), p.931-934

2014

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Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents

International journal of molecular sciences, 2023-02, Vol.24 (4), p.4167

2023

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Coronary heart disease risk factors take a disproportional toll on women

Arteriosclerosis, thrombosis, and vascular biology, 2015-04, Vol.35 (4), p.750-751

2015

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Platelet Functional Testing Via High‐Throughput Microtiter Plate‐Based Assays

Current protocols, 2023-02, Vol.3 (2), p.e668-n/a

2023

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Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation

Blood, 2014-10, Vol.124 (14), p.2271-2279

2014

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Fatty acids negatively regulate platelet function through formation of noncanonical 15‐lipoxygenase‐derived eicosanoids

Pharmacology research & perspectives, 2023-02, Vol.11 (1), p.e01056-n/a

2023

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Immunoreceptor Tyrosine-Based Inhibitory Motif (ITIM)-Mediated Inhibitory Signaling Is Regulated by Sequential Phosphorylation Mediated by Distinct Nonreceptor Tyrosine Kinases: A Case Study Involving PECAM‑1

Biochemistry (Easton), 2013-04, Vol.52 (15), p.2597-2608

2013

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Anchoring IgG-degrading enzymes to the surface of platelets selectively neutralizes antiplatelet antibodies

Blood advances, 2022-08, Vol.6 (15), p.4645-4656

2022

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12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor

Blood advances, 2017-06, Vol.1 (15), p.1124-1131

2017

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The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa B

The Journal of immunology (1950), 2010-03, Vol.184 (6), p.3157-3163

2010

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Abstract 59: Disparity in Protection from Thrombotic Risk Depends on Platelet Thrombin Receptor PAR4

Arteriosclerosis, thrombosis, and vascular biology, 2015-05, Vol.35 (suppl_1)

2015

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Inflammation, Infection and Venous Thromboembolism

Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5[S]

ENTPD-1 disrupts inflammasome IL-1β–driven venous thrombosis

The emerging role of oxylipins in thrombosis and diabetes

Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race

Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics

5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1

Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis

First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis

5S,15S‑Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5‑Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase‑1

12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-γ-Linolenic Acid, Inhibits Thrombosis via Gαs Signaling in Platelets

Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators

Role of Human 15-Lipoxygenase‑2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase‑1

B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia

Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents

Coronary heart disease risk factors take a disproportional toll on women

Platelet Functional Testing Via High‐Throughput Microtiter Plate‐Based Assays

Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation

Fatty acids negatively regulate platelet function through formation of noncanonical 15‐lipoxygenase‐derived eicosanoids

Immunoreceptor Tyrosine-Based Inhibitory Motif (ITIM)-Mediated Inhibitory Signaling Is Regulated by Sequential Phosphorylation Mediated by Distinct Nonreceptor Tyrosine Kinases: A Case Study Involving PECAM‑1

Anchoring IgG-degrading enzymes to the surface of platelets selectively neutralizes antiplatelet antibodies

12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor

The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa B

Abstract 59: Disparity in Protection from Thrombotic Risk Depends on Platelet Thrombin Receptor PAR4

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