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The Conformational Switch from the Factor X Zymogen to Protease State Mediates Exosite Expression and Prothrombinase Assembly

The Journal of biological chemistry, 2008-07, Vol.283 (27), p.18627-18635

2008

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Preclinical assessment of an optimized AAV-FVIII vector in mice and non-human primates for the treatment of hemophilia A

Molecular therapy. Methods & clinical development, 2022-03, Vol.24, p.20-29

2022

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Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Blood, 2009-11, Vol.114 (20), p.4562-4565

2009

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Removal of B-domain Sequences from Factor V Rather than Specific Proteolysis Underlies the Mechanism by Which Cofactor Function Is Realized

The Journal of biological chemistry, 2004-05, Vol.279 (20), p.21643-21650

2004

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Inhibitory Sequences within the B-domain Stabilize Circulating Factor V in an Inactive State

The Journal of biological chemistry, 2007-05, Vol.282 (20), p.15033-15039

2007

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Role of Hirudin-like Factor Va Heavy Chain Sequences in Prothrombinase Function

The Journal of biological chemistry, 2006-03, Vol.281 (13), p.8773-8779

2006

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Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitro

Blood, 2011-01, Vol.117 (1), p.290-298

2011

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The C-Terminus Basic Region of TFPIα Dynamically Regulates FV(a) Function: Evaluation of FV-Short

Blood, 2014-12, Vol.124 (21), p.578-578

2014

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Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice

Blood, 2015-11, Vol.126 (21), p.2415-2423

2015

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A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia

Nature biotechnology, 2011-11, Vol.29 (11), p.1028-1033

2011

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Adeno-Associated Viral Vector Delivery of Optimized Human Factor VIII Achieves Therapeutic Factor VIII Levels in Non-Human Primates

Blood, 2015-12, Vol.126 (23), p.199-199

2015

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Mapping the Location of Autoinhibitory B-Domain Motifs within Factor V: New Insights Into How Factor V Activation Unfolds

Blood, 2012-11, Vol.120 (21), p.495-495

2012

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52. Therapeutic Factor VIII Expression After AAV Delivery in Non-Human Primates

Molecular therapy, 2016-05, Vol.24, p.S52-S52

2016

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Ocular Gene Therapy-The Future Is Now

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.), 2016-07, Vol.5 (4), p.227-228

2016

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Factor V Inhibits PAR2-Mediated Lethal Inflammation

Blood, 2012-11, Vol.120 (21), p.3360-3360

2012

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Modulation of factor VII levels by intron 7 polymorphisms: population and in vitro studies

Blood, 2000-06, Vol.95 (11), p.3423-3428

2000

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Alteration of the Factor X Zymogen to Protease Transition Provides Evidence for Allosteric Linkage between the S1 and FVa Binding Sites

Blood, 2005-11, Vol.106 (11), p.30-30

2005

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The Development of Novel Hemostatic Bypassing Molecules

Blood, 2009-11, Vol.114 (22), p.SCI-20-SCI-20

2009

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Correction of the coagulation defect in hemophilia using a factor Xa variant with novel engineered protease function

Nature biotechnology, 2011-10, Vol.29 (11), p.1028-1033

2011

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Zymogen-Like Factor Xa Variants Restore Thrombin Generation and Effectively Bypass the Intrinsic Pathway in Vitro

Blood, 2008-11, Vol.112 (11), p.240-240

2008

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Destabilization of the Factor V B-Domain Results in Procofactor Activation

Blood, 2006-11, Vol.108 (11), p.198-198

2006

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The Contribution of Hirudin-Like Acidic Sequences within the Factor Va Heavy Chain to Prothrombinase Function

Blood, 2004-11, Vol.104 (11), p.1714-1714

2004

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Factor Xa Variants as Novel Bypass Agents for the Treatment of Hemophilia in Murine Models

Blood, 2008-11, Vol.112 (11), p.239-239

2008

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Successful Production of Canine FVIII: Biochemical and Functional Characterization in Hemophilia A Dogs

Blood, 2007-11, Vol.110 (11), p.495-495

2007

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A frequent human coagulation Factor VII mutation (A294V, c152) in loop 140s affects the interaction with activators, tissue factor and substrates

Biochemical journal, 2002-04, Vol.363 (Pt 2), p.411-416

2002

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The Conformational Switch from the Factor X Zymogen to Protease State Mediates Exosite Expression and Prothrombinase Assembly

Preclinical assessment of an optimized AAV-FVIII vector in mice and non-human primates for the treatment of hemophilia A

Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Removal of B-domain Sequences from Factor V Rather than Specific Proteolysis Underlies the Mechanism by Which Cofactor Function Is Realized

Inhibitory Sequences within the B-domain Stabilize Circulating Factor V in an Inactive State

Role of Hirudin-like Factor Va Heavy Chain Sequences in Prothrombinase Function

Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitro

The C-Terminus Basic Region of TFPIα Dynamically Regulates FV(a) Function: Evaluation of FV-Short

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice

A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia

Adeno-Associated Viral Vector Delivery of Optimized Human Factor VIII Achieves Therapeutic Factor VIII Levels in Non-Human Primates

Mapping the Location of Autoinhibitory B-Domain Motifs within Factor V: New Insights Into How Factor V Activation Unfolds

52. Therapeutic Factor VIII Expression After AAV Delivery in Non-Human Primates

Ocular Gene Therapy-The Future Is Now

Factor V Inhibits PAR2-Mediated Lethal Inflammation

Modulation of factor VII levels by intron 7 polymorphisms: population and in vitro studies

Alteration of the Factor X Zymogen to Protease Transition Provides Evidence for Allosteric Linkage between the S1 and FVa Binding Sites

The Development of Novel Hemostatic Bypassing Molecules

Correction of the coagulation defect in hemophilia using a factor Xa variant with novel engineered protease function

Zymogen-Like Factor Xa Variants Restore Thrombin Generation and Effectively Bypass the Intrinsic Pathway in Vitro

Destabilization of the Factor V B-Domain Results in Procofactor Activation

The Contribution of Hirudin-Like Acidic Sequences within the Factor Va Heavy Chain to Prothrombinase Function

Factor Xa Variants as Novel Bypass Agents for the Treatment of Hemophilia in Murine Models

Successful Production of Canine FVIII: Biochemical and Functional Characterization in Hemophilia A Dogs

A frequent human coagulation Factor VII mutation (A294V, c152) in loop 140s affects the interaction with activators, tissue factor and substrates

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