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Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening

PLoS neglected tropical diseases, 2018-11, Vol.12 (11), p.e0006969-e0006969

2018

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Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme

PLoS neglected tropical diseases, 2020-05, Vol.14 (5), p.e0008339-e0008339

2020

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Asymmetric Synthesis of Benzylic Quaternary Difunctionalized Carbons Mediated by a Remote Sulfinyl Group

Journal of organic chemistry, 2011-05, Vol.76 (9), p.3597-3603

2011

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Stereodivergent Quaternization of 2-Alkyl-2-p-tolylsulfinylacetonitriles: NMR Spectroscopic Evidence of Planar and Pyramidal Benzylic Carbanions

Chemistry : a European journal, 2010-06, Vol.16 (21), p.6317-6325

2010

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Direct-to-biology platform: From synthesis to biological evaluation of SHP2 allosteric inhibitors

Bioorganic & medicinal chemistry letters, 2024-03, Vol.100, p.129626-129626, Article 129626

2024

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Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERBβ and Autophagy

Journal of medicinal chemistry, 2015-08, Vol.58 (15), p.5900-5915

2015

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A Catalytic Asymmetric Reaction Involving Enolizable Anhydrides

Organic letters, 2012-04, Vol.14 (7), p.1850-1853

2012

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Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis

Angewandte Chemie (International ed.), 2016-09, Vol.55 (37), p.11193-11197

International ed. in English, 2016

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The first catalytic asymmetric cycloadditions of imines with an enolisable anhydride

Organic & biomolecular chemistry, 2016-01, Vol.14 (29), p.6955-6959

2016

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Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors

ACS medicinal chemistry letters, 2023-02, Vol.14 (2), p.156-162

2023

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Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

ACS medicinal chemistry letters, 2020-05, Vol.11 (5), p.740-746

2020

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The first catalytic asymmetric cycloadditions of imines with an enolisable anhydrideElectronic supplementary information (ESI) available: Experimental procedures, spectral, X-ray and characterisation data. CCDC 1481218. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ob00048g

2016-07

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Asymmetric 1,3-dipolar reactions of cyclic vinyl p-tolyl sulfimines with diazoalkanes

ARKIVOC, 2005-03, Vol.2005 (9), p.146-158

2005

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Use of Lithiated Chiral o‑Sulfinylbenzyl Carbanions for the One-Pot Building of Linear Fragments Containing up to Four Connected Stereocenters

Journal of organic chemistry, 2013-01, Vol.78 (2), p.647-657

2013

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Synthesis of Enantiomerically Pure anti-1,2-Diaryl and syn-1,2-Alkylaryl vic-Selenoamines

Journal of organic chemistry, 2012-02, Vol.77 (4), p.1974-1982

2012

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Asymmetric Intramolecular Pauson–Khand Reaction Mediated by a Remote Sulfenyl or Sulfinyl Group

Journal of organic chemistry, 2012-08, Vol.77 (15), p.6583-6599

2012

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Stereoselective Michael additions of lithiated ortho-sulfinylbenzyl carbanions derived from [alpha]-amino nitriles

Journal of sulfur chemistry, 2013-12, Vol.34 (6), p.559

2013

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Efficient Synthesis of Enantiomerically Pure α-Alkyl Cyclopropanecarbonitrile Derivatives from Pyrazolines

Organic letters, 2004-12, Vol.6 (26), p.4945-4948

2004

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Stereoselective synthesis of 2,3-epoxy alcohols mediated by a remote sulfinyl group

Tetrahedron, 2010-02, Vol.66 (8), p.1581-1585

2010

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Influence of an ortho-sulfinyl group on the configurational stability of α-lithiated aryloxiranes: deuteration of tolylsulfinyl styrene oxides

Tetrahedron, 2009-01, Vol.65 (1), p.383-388

2009

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Stereoselective Michael additions of lithiated ortho-sulfinylbenzyl carbanions derived from α-amino nitriles

Journal of sulfur chemistry, 2013-12, Vol.34 (6), p.559-565

2013

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Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis

Angewandte Chemie, 2016-09, Vol.128 (37), p.11359-11363

2016

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Diastereodivergent Synthesis of Benzylic Quaternary Centers Mediated by a Remote Sulfinyl Group: Spectroscopic Evidence of the Structure of the Carbanionic Intermediates

Phosphorus, sulfur, and silicon and the related elements, 2011-05, Vol.186 (5), p.1119-1129

2011

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Synthesis of Enantiomerically Pure 1,2-Disubstituted 2-Selenoamines

Phosphorus, sulfur, and silicon and the related elements, 2011-05, Vol.186 (5), p.1268-1273

2011

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Efficient Enantioselective Synthesis of Cyclopropanes from Sulfonylpyrazolines

Phosphorus, sulfur, and silicon and the related elements, 2005-05, Vol.180 (5-6), p.1445-1446

2005

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Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening

Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme

Asymmetric Synthesis of Benzylic Quaternary Difunctionalized Carbons Mediated by a Remote Sulfinyl Group

Stereodivergent Quaternization of 2-Alkyl-2-p-tolylsulfinylacetonitriles: NMR Spectroscopic Evidence of Planar and Pyramidal Benzylic Carbanions

Direct-to-biology platform: From synthesis to biological evaluation of SHP2 allosteric inhibitors

Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERBβ and Autophagy

A Catalytic Asymmetric Reaction Involving Enolizable Anhydrides

Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis

The first catalytic asymmetric cycloadditions of imines with an enolisable anhydride

Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors

Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

Asymmetric 1,3-dipolar reactions of cyclic vinyl p-tolyl sulfimines with diazoalkanes

Use of Lithiated Chiral o‑Sulfinylbenzyl Carbanions for the One-Pot Building of Linear Fragments Containing up to Four Connected Stereocenters

Synthesis of Enantiomerically Pure anti-1,2-Diaryl and syn-1,2-Alkylaryl vic-Selenoamines

Asymmetric Intramolecular Pauson–Khand Reaction Mediated by a Remote Sulfenyl or Sulfinyl Group

Stereoselective Michael additions of lithiated ortho-sulfinylbenzyl carbanions derived from [alpha]-amino nitriles

Efficient Synthesis of Enantiomerically Pure α-Alkyl Cyclopropanecarbonitrile Derivatives from Pyrazolines

Stereoselective synthesis of 2,3-epoxy alcohols mediated by a remote sulfinyl group

Influence of an ortho-sulfinyl group on the configurational stability of α-lithiated aryloxiranes: deuteration of tolylsulfinyl styrene oxides

Stereoselective Michael additions of lithiated ortho-sulfinylbenzyl carbanions derived from α-amino nitriles

Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis

Diastereodivergent Synthesis of Benzylic Quaternary Centers Mediated by a Remote Sulfinyl Group: Spectroscopic Evidence of the Structure of the Carbanionic Intermediates

Synthesis of Enantiomerically Pure 1,2-Disubstituted 2-Selenoamines

Efficient Enantioselective Synthesis of Cyclopropanes from Sulfonylpyrazolines

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