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Drug design from the cryptic inhibitor envelope

Nature communications, 2016-02, Vol.7 (1), p.10638-10638, Article 10638

2016

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In Situ Growth of a Stoichiometric Peg-Like Conjugate at a Protein's N-terminus with Significantly Improved Pharmacokinetics

Proceedings of the National Academy of Sciences - PNAS, 2009-09, Vol.106 (36), p.15231-15236

2009

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Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis

PloS one, 2014-02, Vol.9 (2), p.e88983-e88983

2014

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Derivatives of Plant Phenolic Compound Affect the Type III Secretion System of Pseudomonas aeruginosa via a GacS-GacA Two-Component Signal Transduction System

Antimicrobial Agents and Chemotherapy, 2012-01, Vol.56 (1), p.36-43

2012

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Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC

mBio, 2017-07, Vol.8 (4)

2017

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Improving upon Nature: Active Site Remodeling Produces Highly Efficient Aldolase Activity toward Hydrophobic Electrophilic Substrates

Biochemistry (Easton), 2012-02, Vol.51 (8), p.1658-1668

2012

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Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis

Proceedings of the National Academy of Sciences - PNAS, 2011-06, Vol.108 (25), p.10284-10289

2011

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A Small-Molecule Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase with Antitumor Activity in Cancer Cells

Proceedings of the National Academy of Sciences - PNAS, 2005-03, Vol.102 (12), p.4336-4341

2005

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The Cluster Glycoside Effect

Chemical reviews, 2002-02, Vol.102 (2), p.555-578

2002

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Soft-Lithographic Approach to Functionalization and Nanopatterning Oxide-Free Silicon

Langmuir, 2011-05, Vol.27 (10), p.6478-6485

2011

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Identification and Inhibitory Properties of a Novel Ca2+/Calmodulin Antagonist

Biochemistry (Easton), 2010-05, Vol.49 (19), p.4244-4254

2010

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On the Meaning of Affinity: Cluster Glycoside Effects and Concanavalin A

Journal of the American Chemical Society, 1999-11, Vol.121 (44), p.10286-10296

1999

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Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.6954-6966

2013

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Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens

Science translational medicine, 2023-08, Vol.15 (708), p.eadf5668

2023

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A general and efficient cantilever functionalization technique for AFM molecular recognition studies

Biopolymers, 2012-10, Vol.97 (10), p.761-765

2012

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A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058

Journal of organic chemistry, 2016-05, Vol.81 (10), p.4393-4398

2016

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A Direct Measure of the Contribution of Solvent Reorganization to the Enthalpy of Binding

Journal of the American Chemical Society, 1994-11, Vol.116 (23), p.10533-10539

1994

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High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors

Journal of antimicrobial chemotherapy, 2016-10, Vol.71 (10), p.2874-2882

2016

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Multivalency Effects in Protein−Carbohydrate Interaction: The Binding of the Shiga-like Toxin 1 Binding Subunit to Multivalent C-Linked Glycopeptides

Journal of organic chemistry, 2000-12, Vol.65 (24), p.8245-8250

2000

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Specific Binding at the Cellulose Binding Module–Cellulose Interface Observed by Force Spectroscopy

Langmuir, 2015-03, Vol.31 (11), p.3431-3440

2015

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stochastic, cantilever approach to the evaluation of solution phase thermodynamic quantities

Proceedings of the National Academy of Sciences - PNAS, 2007-02, Vol.104 (8), p.2579-2584

2007

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Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC

ACS chemical biology, 2014-01, Vol.9 (1), p.237-246

2014

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Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold

Bioorganic & medicinal chemistry, 2011-01, Vol.19 (2), p.852-860

2011

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S-Nitrosothiol Repletion by an Inhaled Gas Regulates Pulmonary Function

Proceedings of the National Academy of Sciences - PNAS, 2001-05, Vol.98 (10), p.5792-5797

2001

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Practical synthesis of fully protected globotriaose and its glycopolymers

Carbohydrate polymers, 2007-06, Vol.69 (2), p.326-335

2007

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Drug design from the cryptic inhibitor envelope

In Situ Growth of a Stoichiometric Peg-Like Conjugate at a Protein's N-terminus with Significantly Improved Pharmacokinetics

Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis

Derivatives of Plant Phenolic Compound Affect the Type III Secretion System of Pseudomonas aeruginosa via a GacS-GacA Two-Component Signal Transduction System

Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC

Improving upon Nature: Active Site Remodeling Produces Highly Efficient Aldolase Activity toward Hydrophobic Electrophilic Substrates

Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis

A Small-Molecule Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase with Antitumor Activity in Cancer Cells

The Cluster Glycoside Effect

Soft-Lithographic Approach to Functionalization and Nanopatterning Oxide-Free Silicon

Identification and Inhibitory Properties of a Novel Ca2+/Calmodulin Antagonist

On the Meaning of Affinity: Cluster Glycoside Effects and Concanavalin A

Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors

Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens

A general and efficient cantilever functionalization technique for AFM molecular recognition studies

A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058

A Direct Measure of the Contribution of Solvent Reorganization to the Enthalpy of Binding

High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors

Multivalency Effects in Protein−Carbohydrate Interaction: The Binding of the Shiga-like Toxin 1 Binding Subunit to Multivalent C-Linked Glycopeptides

Specific Binding at the Cellulose Binding Module–Cellulose Interface Observed by Force Spectroscopy

stochastic, cantilever approach to the evaluation of solution phase thermodynamic quantities

Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC

Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold

S-Nitrosothiol Repletion by an Inhaled Gas Regulates Pulmonary Function

Practical synthesis of fully protected globotriaose and its glycopolymers

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