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Short-term mortality and morbidity of very low-birthweight infants over 9 years at Groote Schuur Hospital, Cape Town, South Africa

SAJCH : the South African journal of child health, 2024-07, Vol.18 (2), p.e1516-102

2024

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Symptomatic congenital syphilis in a tertiary neonatal unit in Cape Town, South Africa : high morbidity and mortality in a preventable disease

SAMJ: South African Medical Journal, 2019-09, Vol.109 (9), p.652-658

2019

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An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography

Nature communications, 2021-07, Vol.12 (1), p.4461-4461, Article 4461

2021

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Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics

PLoS pathogens, 2024-06, Vol.20 (6), p.e1012235

2024

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Short-term outcomes of inborn v. outborn very-low-birth-weight neonates (<1 500 g) in the neonatal nursery at Groote Schuur Hospital, Cape Town, South Africa

SAMJ: South African Medical Journal, 2017-10, Vol.107 (10), p.900-903

2017

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Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics

eLife, 2021-03, Vol.10

2021

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β-Lactamases and β-Lactamase Inhibitors in the 21st Century

Journal of molecular biology, 2019-08, Vol.431 (18), p.3472-3500

2019

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Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition

mBio, 2022-06, Vol.13 (3), p.e0179321-e0179321

2022

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Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2

Antibiotics (Basel), 2022-03, Vol.11 (3), p.396

2022

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Short-term outcomes of very low-birthweight infants with intraventricular haemorrhage who received respiratory support in a middle-income country neonatal unit

SAJCH : the South African journal of child health, 2021-09, Vol.15 (3), p.130

2021

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Illness episodes in a cohort of preterm infants in their first year of life

SAJCH : the South African journal of child health, 2021-04, Vol.15 (1), p.44-49

2021

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Syringe drivers: incorrect selection of syringe type from the syringe menu may result in significant errors in drug delivery

Anaesthesia and intensive care, 2014-07, Vol.42 (4), p.467-472

2014

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Interscapular site for transcutaneous bilirubin measurement in preterm infants: a better and safer screening site

Journal of perinatology, 2014-03, Vol.34 (3), p.209-212

2014

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Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl–enzyme conformational dynamics to extend antibiotic resistance

The Journal of biological chemistry, 2021-01, Vol.296, p.100126, Article 100126

2021

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Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

Antimicrobial agents and chemotherapy, 2019-10, Vol.63 (10)

2019

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Illness episodes in a cohort of preterm infants in their first year of life

SAJCH : the South African journal of child health, 2021-04, Vol.15 (1), p.44

2021

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Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes

Proceedings of the National Academy of Sciences - PNAS, 2016-06, Vol.113 (26), p.E3745-E3754

2016

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Anaesthetic method and short-term outcomes of preterm infants delivered by caesarean section at a tertiary hospital in South Africa

SAJCH : the South African journal of child health, 2019-09, Vol.13 (3), p.125-129

2019

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Tautomer-Specific Deacylation and Ω‑Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC‑2 β‑Lactamase

Journal of the American Chemical Society, 2023-04, Vol.145 (13), p.7166-7180

2023

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Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β‑Lactamase-Activated Antibacterial Prodrug

Journal of medicinal chemistry, 2019-05, Vol.62 (9), p.4411-4425

2019

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Dynamical responses predict a distal site that modulates activity in an antibiotic resistance enzyme

Chemical science (Cambridge), 2024-09, Vol.15 (41), p.17232-17244

2024

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Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1

Scientific reports, 2017-01, Vol.7 (1), p.39392, Article 39392

2017

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A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation

Angewandte Chemie International Edition, 2018-01, Vol.57 (5), p.1282-1285

International ed. in English, 2018

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Profiling interactions of vaborbactam with metallo-β-lactamases

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (15), p.1981-1984

2019

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Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation

Scientific reports, 2019-09, Vol.9 (1), p.13608-9, Article 13608

2019

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Short-term mortality and morbidity of very low-birthweight infants over 9 years at Groote Schuur Hospital, Cape Town, South Africa

Symptomatic congenital syphilis in a tertiary neonatal unit in Cape Town, South Africa : high morbidity and mortality in a preventable disease

An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography

Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics

Short-term outcomes of inborn v. outborn very-low-birth-weight neonates (<1 500 g) in the neonatal nursery at Groote Schuur Hospital, Cape Town, South Africa

Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics

β-Lactamases and β-Lactamase Inhibitors in the 21st Century

Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition

Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2

Short-term outcomes of very low-birthweight infants with intraventricular haemorrhage who received respiratory support in a middle-income country neonatal unit

Illness episodes in a cohort of preterm infants in their first year of life

Syringe drivers: incorrect selection of syringe type from the syringe menu may result in significant errors in drug delivery

Interscapular site for transcutaneous bilirubin measurement in preterm infants: a better and safer screening site

Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl–enzyme conformational dynamics to extend antibiotic resistance

Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

Illness episodes in a cohort of preterm infants in their first year of life

Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes

Anaesthetic method and short-term outcomes of preterm infants delivered by caesarean section at a tertiary hospital in South Africa

Tautomer-Specific Deacylation and Ω‑Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC‑2 β‑Lactamase

Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β‑Lactamase-Activated Antibacterial Prodrug

Dynamical responses predict a distal site that modulates activity in an antibiotic resistance enzyme

Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1

A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation

Profiling interactions of vaborbactam with metallo-β-lactamases

Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation

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