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Inhibition of Protein−Protein Association by Small Molecules: Approaches and Progress

Journal of medicinal chemistry, 2002-04, Vol.45 (8), p.1543-1558

Toogood, Peter L

2002

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Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts

Molecular cancer therapeutics, 2004-11, Vol.3 (11), p.1427-1438

2004

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Synthesis of (−)-PNU-286607 by Asymmetric Cyclization of Alkylidene Barbiturates

Journal of the American Chemical Society, 2009-03, Vol.131 (11), p.3991-3997

2009

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Discovery of a Potent and Selective Inhibitor of Cyclin-Dependent Kinase 4/6

Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2388-2406

2005

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Small molecule immuno-oncology therapeutic agents

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (3), p.319-329

Toogood, Peter L.

2018

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A novel therapeutic combination using PD 0332991 and bortezomib: study in the 5T33MM myeloma model

Cancer research (Chicago, Ill.), 2008-07, Vol.68 (14), p.5519-5523

2008

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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?

Pharmacological research, 2021-03, Vol.165, p.105465-105465, Article 105465

2021

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Cyclin-dependent kinase inhibitors for treating cancer

Medicinal research reviews, 2001-11, Vol.21 (6), p.487-498

Toogood, Peter L.

2001

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Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists

Nature chemical biology, 2015-02, Vol.11 (2), p.141

2015

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Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists

Nature chemical biology, 2015-01, Vol.11 (2), p.141-147

2015

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Mitochondrial drugs

Current opinion in chemical biology, 2008-08, Vol.12 (4), p.457-463

Toogood, Peter L

2008

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COVID-19: Living through Another Pandemic

ACS infectious diseases, 2020-07, Vol.6 (7), p.1548-1552

2020

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Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor‑γ (RORγ) Agonist for Use in Treating Cancer

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13410-13428

2021

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Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity

Oncoimmunology, 2016-12, Vol.5 (12), p.e1254854-e1254854

2016

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A Short and Efficient Synthesis of l-5,5,5,5‘,5‘,5‘-hexafluoroleucine from N-Cbz-l-Serine

Organic letters, 2002-11, Vol.4 (24), p.4281-4283

2002

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Pyrido[2,3-d]pyrimidin-7-ones as Specific Inhibitors of Cyclin-Dependent Kinase 4

Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2371-2387

2005

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Progress toward the development of agents to modulate the cell cycle

Current Opinion in Chemical Biology, 2002-08, Vol.6 (4), p.472-478

Toogood, Peter L

2002

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Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.665-669

2009

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2-Aminoquinazoline inhibitors of cyclin-dependent kinases

Bioorganic & medicinal chemistry letters, 2005-09, Vol.15 (17), p.3881-3885

2005

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Inhibition of Protein Synthesis by Didemnin B: How EF-1α Mediates Inhibition of Translocation

Biochemistry (Easton), 2000-04, Vol.39 (15), p.4339-4346

2000

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Total Synthesis of Motuporin and 5-[l-Ala]-Motuporin

Journal of organic chemistry, 1999-04, Vol.64 (8), p.2711-2728

1999

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Mechanism of Protein Synthesis Inhibition by Didemnin B in Vitro

Biochemistry (Easton), 1995-07, Vol.34 (28), p.9177-9184

1995

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Inhibition of protein synthesis by didemnin B is not sufficient to induce apoptosis in human mammary carcinoma (MCF7) cells

Biochemical pharmacology, 1999-09, Vol.58 (6), p.1067-1074

1999

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Inhibition of Protein Synthesis by Didemnins: Cell Potency and SAR

Journal of medicinal chemistry, 2000-11, Vol.43 (22), p.4212-4218

2000

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Sodium-directed selective cleavage of lactones: a method for structure determination of cyclodepsipeptides

International journal of mass spectrometry, 1999-03, Vol.182, p.289-298

1999

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Inhibition of Protein−Protein Association by Small Molecules: Approaches and Progress

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts

Synthesis of (−)-PNU-286607 by Asymmetric Cyclization of Alkylidene Barbiturates

Discovery of a Potent and Selective Inhibitor of Cyclin-Dependent Kinase 4/6

Small molecule immuno-oncology therapeutic agents

A novel therapeutic combination using PD 0332991 and bortezomib: study in the 5T33MM myeloma model

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?

Cyclin-dependent kinase inhibitors for treating cancer

Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists

Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists

Mitochondrial drugs

COVID-19: Living through Another Pandemic

Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor‑γ (RORγ) Agonist for Use in Treating Cancer

Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity

A Short and Efficient Synthesis of l-5,5,5,5‘,5‘,5‘-hexafluoroleucine from N-Cbz-l-Serine

Pyrido[2,3-d]pyrimidin-7-ones as Specific Inhibitors of Cyclin-Dependent Kinase 4

Progress toward the development of agents to modulate the cell cycle

Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase

2-Aminoquinazoline inhibitors of cyclin-dependent kinases

Inhibition of Protein Synthesis by Didemnin B: How EF-1α Mediates Inhibition of Translocation

Total Synthesis of Motuporin and 5-[l-Ala]-Motuporin

Mechanism of Protein Synthesis Inhibition by Didemnin B in Vitro

Inhibition of protein synthesis by didemnin B is not sufficient to induce apoptosis in human mammary carcinoma (MCF7) cells

Inhibition of Protein Synthesis by Didemnins: Cell Potency and SAR

Sodium-directed selective cleavage of lactones: a method for structure determination of cyclodepsipeptides

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