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Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

Nature communications, 2020-12, Vol.11 (1), p.6310-6310, Article 6310

2020

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Mutations in Iron-Sulfur Cluster Scaffold Genes NFU1 and BOLA3 Cause a Fatal Deficiency of Multiple Respiratory Chain and 2-Oxoacid Dehydrogenase Enzymes

American journal of human genetics, 2011-10, Vol.89 (4), p.486-495

2011

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Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis

Cell metabolism, 2006-03, Vol.3 (3), p.199-210

2006

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The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

Cancer cell, 2011-09, Vol.20 (3), p.315-327

2011

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Human ISD11 is essential for both iron–sulfur cluster assembly and maintenance of normal cellular iron homeostasis

Human molecular genetics, 2009-08, Vol.18 (16), p.3014-3025

2009

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Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis

Biometals, 2007-06, Vol.20 (3-4), p.549-564

2007

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Subcellular Compartmentalization of Human Nfu, an Iron-Sulfur Cluster Scaffold Protein, and Its Ability to Assemble a [4Fe-4S] Cluster

Proceedings of the National Academy of Sciences - PNAS, 2003-08, Vol.100 (17), p.9762-9767

2003

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Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery

Blood, 2010-01, Vol.115 (4), p.860-869

2010

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Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (33), p.12028-12033

2008

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Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia

Heliyon, 2022-08, Vol.8 (8), p.e10371-e10371, Article e10371

2022

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TLR-activated repression of Fe-S cluster biogenesis drives a metabolic shift and alters histone and tubulin acetylation

Blood advances, 2018-05, Vol.2 (10), p.1146-1156

2018

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Iron–sulfur cluster biogenesis and human disease

Trends in genetics, 2008-08, Vol.24 (8), p.398-407

2008

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Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells

The EMBO journal, 2000-11, Vol.19 (21), p.5692-5700

2000

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Cochaperone Binding to LYR Motifs Confers Specificity of Iron Sulfur Cluster Delivery

Cell metabolism, 2014-03, Vol.19 (3), p.445-457

2014

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Roles of the Mammalian Cytosolic Cysteine Desulfurase, ISCS, and Scaffold Protein, ISCU, in Iron-Sulfur Cluster Assembly

The Journal of biological chemistry, 2006-05, Vol.281 (18), p.12344-12351

2006

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Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis

Nature reviews. Molecular cell biology, 2005-04, Vol.6 (4), p.345-351

2005

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Tangled Up In Red: Intertwining of the Heme and Iron-Sulfur Cluster Biogenesis Pathways

Cell metabolism, 2009-08, Vol.10 (2), p.80-81

2009

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Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

Cell metabolism, 2013-02, Vol.17 (2), p.271-281

2013

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Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle

Human molecular genetics, 2014-01, Vol.23 (1), p.24-39

2014

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Splice Mutation in the Iron-Sulfur Cluster Scaffold Protein ISCU Causes Myopathy with Exercise Intolerance

American journal of human genetics, 2008-03, Vol.82 (3), p.652-660

2008

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Tissue specificity of a human mitochondrial disease: differentiation-enhanced mis-splicing of the Fe-S scaffold gene ISCU renders patient cells more sensitive to oxidative stress in ISCU myopathy

The Journal of biological chemistry, 2012-11, Vol.287 (48), p.40119-40130

2012

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Biochemical and biophysical methods for studying mitochondrial iron metabolism

Methods in enzymology, 2014, Vol.547, p.275-307

2014

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Iron control of erythroid development by a novel aconitase-associated regulatory pathway

Blood, 2010-07, Vol.116 (1), p.97-108

2010

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Abstract B08: Metabolic adaption in inflammatory macrophages through the modulation of Fe-S cluster biogenesis factors

Molecular cancer research, 2016-01, Vol.14 (1_Supplement), p.B08-B08

2016

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Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development

Blood cells, molecules, & diseases, 2006-03, Vol.36 (2), p.283-287

2006

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Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

Mutations in Iron-Sulfur Cluster Scaffold Genes NFU1 and BOLA3 Cause a Fatal Deficiency of Multiple Respiratory Chain and 2-Oxoacid Dehydrogenase Enzymes

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis

The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

Human ISD11 is essential for both iron–sulfur cluster assembly and maintenance of normal cellular iron homeostasis

Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis

Subcellular Compartmentalization of Human Nfu, an Iron-Sulfur Cluster Scaffold Protein, and Its Ability to Assemble a [4Fe-4S] Cluster

Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery

Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice

Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia

TLR-activated repression of Fe-S cluster biogenesis drives a metabolic shift and alters histone and tubulin acetylation

Iron–sulfur cluster biogenesis and human disease

Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells

Cochaperone Binding to LYR Motifs Confers Specificity of Iron Sulfur Cluster Delivery

Roles of the Mammalian Cytosolic Cysteine Desulfurase, ISCS, and Scaffold Protein, ISCU, in Iron-Sulfur Cluster Assembly

Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis

Tangled Up In Red: Intertwining of the Heme and Iron-Sulfur Cluster Biogenesis Pathways

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle

Splice Mutation in the Iron-Sulfur Cluster Scaffold Protein ISCU Causes Myopathy with Exercise Intolerance

Tissue specificity of a human mitochondrial disease: differentiation-enhanced mis-splicing of the Fe-S scaffold gene ISCU renders patient cells more sensitive to oxidative stress in ISCU myopathy

Biochemical and biophysical methods for studying mitochondrial iron metabolism

Iron control of erythroid development by a novel aconitase-associated regulatory pathway

Abstract B08: Metabolic adaption in inflammatory macrophages through the modulation of Fe-S cluster biogenesis factors

Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development

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