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Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice

European journal of pharmacology, 2013-09, Vol.715 (1-3), p.246-255

2013

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SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats

European journal of pharmacology, 2014-03, Vol.727, p.66-74

2014

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Effects of sodium-glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycaemia, oxidative stress, inflammation and liver injury in streptozotocin-induced type 1 diabetic rats

Journal of pharmacy and pharmacology, 2014-07, Vol.66 (7), p.975-987

2014

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Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo

Naunyn-Schmiedeberg's archives of pharmacology, 2012-04, Vol.385 (4), p.423-436

2012

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Antidiabetic Effects of SGLT2-Selective Inhibitor Ipragliflozin in Streptozotocin–Nicotinamide-Induced Mildly Diabetic Mice

Journal of Pharmacological Sciences, 2012, Vol.120(1), pp.36-44

2012

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Regioselective Alkylation of 2-Alkyl-5,6,7,8-tetrahydro-3H-cycloheptimidazol-4-ones and 2-Alkyl-3H-cycloheptimidazol-4-ones

Chemical and Pharmaceutical Bulletin, 2006, Vol.54(5), pp.706-710

2006

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Effects of the SGLT2 inhibitor ipragliflozin on food intake, appetite-regulating hormones, and arteriovenous differences in postprandial glucose levels in type 2 diabetic rats

Biomedicine & pharmacotherapy, 2018-09, Vol.105, p.1033-1041

2018

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Effective Preparation of Cycloheptimidazol-4-one Compounds

Chemical and Pharmaceutical Bulletin, 2006, Vol.54(5), pp.703-705

2006

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Discovery of ASP5878: Synthesis and structure–activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity

Bioorganic & medicinal chemistry, 2022-04, Vol.59, p.116657-116657, Article 116657

2022

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Antidiabetic Effects of SGLT2-Selective Inhibitor Ipragliflozin in Streptozotocin^|^ndash;Nicotinamide-Induced Mildly Diabetic Mice

Journal of pharmacological sciences, 2012, Vol.120 (1), p.36-44

2012

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Synthesis and structure–activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) inhibitors

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (8), p.1683-1692

2019

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Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2

Bioorganic & medicinal chemistry, 2020-05, Vol.28 (10), p.115453, Article 115453

2020

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Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus

Bioorganic & medicinal chemistry, 2012-05, Vol.20 (10), p.3263-3279

2012

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Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Bioorganic & medicinal chemistry, 2021-03, Vol.33, p.116019-116019, Article 116019

2021

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Nitrous oxide can enhance the hypnotic effect, but not the suppression of spinal motor neuron excitability by propofol in humans

Journal of anesthesia, 2006-08, Vol.20 (3), p.173-178

2006

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Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: Discovery of YM543

Bioorganic & medicinal chemistry, 2013-07, Vol.21 (13), p.3934-3948

2013

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Catalytic asymmetric intramolecular cyclopropanation of enol silyl ether. Synthesis of the phorbol CD-ring skeleton

Tetrahedron letters, 1996-04, Vol.37 (14), p.2449-2452

1996

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Synthesis of a C-Glycoside Analogue of sTn: An HIV- and Tumor-Associated Antigen

Angewandte Chemie (International ed.), 2003-05, Vol.42 (18), p.2073-2075

2003

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Pharmacological Characterization of YM543, a Newly Synthesized, Orally Active SGLT2 Selective Inhibitor

Endocrine research, 2013-08, Vol.38 (3), p.168-183

2013

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Synthesis of Double C-Glycoside Analogue of sTn

Journal of organic chemistry, 2005-09, Vol.70 (20), p.8197-8200

2005

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Ordered structure in dilute solutions of biopolymers as studied by small-angle x-ray scattering

The Journal of chemical physics, 1985-07, Vol.83 (1), p.378-387

1985

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Synthesis of a C‐Glycoside Analogue of sTn: An HIV‐ and Tumor‐Associated Antigen

Angewandte Chemie, 2003-05, Vol.115 (18), p.2119-2121

2003

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The Infusion Rate Select Mode of a Disposable Continuous Infusion Pump Induce a Large Variation in the Infusion Rate

THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA, 2000/03/15, Vol.20(2), pp.123-126

2000

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Sivelestat sodium hydrate was effective for ARDS in a patient suffering from chronic rheumatoid arthritis with acute exacerbation after failing to respond to high dose steroid pulse therapy

Masui. The Japanese journal of anesthesiology, 2004-09, Vol.53 (9), p.1042

2004

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Withdrawal syndrome in a critically ill child after sedation with midazolam and fentanyl

Masui. The Japanese journal of anesthesiology, 2004-07, Vol.53 (7), p.791

2004

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Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice

SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats

Effects of sodium-glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycaemia, oxidative stress, inflammation and liver injury in streptozotocin-induced type 1 diabetic rats

Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo

Antidiabetic Effects of SGLT2-Selective Inhibitor Ipragliflozin in Streptozotocin–Nicotinamide-Induced Mildly Diabetic Mice

Regioselective Alkylation of 2-Alkyl-5,6,7,8-tetrahydro-3H-cycloheptimidazol-4-ones and 2-Alkyl-3H-cycloheptimidazol-4-ones

Effects of the SGLT2 inhibitor ipragliflozin on food intake, appetite-regulating hormones, and arteriovenous differences in postprandial glucose levels in type 2 diabetic rats

Effective Preparation of Cycloheptimidazol-4-one Compounds

Discovery of ASP5878: Synthesis and structure–activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity

Antidiabetic Effects of SGLT2-Selective Inhibitor Ipragliflozin in Streptozotocin^|^ndash;Nicotinamide-Induced Mildly Diabetic Mice

Synthesis and structure–activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) inhibitors

Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2

Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Nitrous oxide can enhance the hypnotic effect, but not the suppression of spinal motor neuron excitability by propofol in humans

Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: Discovery of YM543

Catalytic asymmetric intramolecular cyclopropanation of enol silyl ether. Synthesis of the phorbol CD-ring skeleton

Synthesis of a C-Glycoside Analogue of sTn: An HIV- and Tumor-Associated Antigen

Pharmacological Characterization of YM543, a Newly Synthesized, Orally Active SGLT2 Selective Inhibitor

Synthesis of Double C-Glycoside Analogue of sTn

Ordered structure in dilute solutions of biopolymers as studied by small-angle x-ray scattering

Synthesis of a C‐Glycoside Analogue of sTn: An HIV‐ and Tumor‐Associated Antigen

The Infusion Rate Select Mode of a Disposable Continuous Infusion Pump Induce a Large Variation in the Infusion Rate

Sivelestat sodium hydrate was effective for ARDS in a patient suffering from chronic rheumatoid arthritis with acute exacerbation after failing to respond to high dose steroid pulse therapy

Withdrawal syndrome in a critically ill child after sedation with midazolam and fentanyl

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