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Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

The Journal of biological chemistry, 2009-09, Vol.284 (36), p.24185-24191

2009

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The atomic-resolution structure of human caspase-8, a key activator of apoptosis

Structure (London), 1999-09, Vol.7 (9), p.1135-1143

1999

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Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6

Journal of molecular biology, 2010-07, Vol.400 (3), p.413-433

2010

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Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1

Bioorganic & medicinal chemistry letters, 2007-06, Vol.17 (12), p.3378-3383

2007

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Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Nature (London), 1999-12, Vol.402 (6761), p.533-537

1999

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Autoactivation of human ADAM8: a novel pre-processing step is required for catalytic activity

Bioscience reports, 2009-08, Vol.29 (4), p.217-228

2009

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Differential kinetics and inhibition of purified recombinant tyrosine kinase 2 (TYK-2) and its catalytic domain JH-1

Protein and peptide letters, 2012-05, Vol.19 (5), p.485-491

2012

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Employing a superior BACE1 cleavage sequence to probe cellular APP processing

Journal of neurochemistry, 2003-03, Vol.84 (5), p.1006-1017

2003

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The titerless infected-cells preservation and scale-up (TIPS) method for large-scale production of NO-sensitive human soluble guanylate cyclase (sGC) from insect cells infected with recombinant baculovirus

Protein expression and purification, 2009-06, Vol.65 (2), p.122-132

2009

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Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.776-781

2007

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Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors

Biochimica et biophysica acta, 2010-09, Vol.1804 (9), p.1817-1831

2010

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Structure analysis reveals the flexibility of the ADAMTS‐5 active site

Protein science, 2011-04, Vol.20 (4), p.735-744

2011

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ADAM8 substrate specificity: Influence of pH on pre-processing and proteoglycan degradation

Archives of biochemistry and biophysics, 2009-11, Vol.491 (1), p.106-111

2009

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Design of potent inhibitors of human β-secretase. Part 1

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.73-77

2007

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Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family

Biochemical and biophysical research communications, 2010-05, Vol.396 (2), p.543-548

2010

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Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain

Protein expression and purification, 2010-01, Vol.69 (1), p.54-63

2010

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Design of potent inhibitors of human β-secretase. Part 2

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.78-81

2007

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High yield purification of soluble guanylate cyclase from bovine lung

Protein expression and purification, 2008-07, Vol.60 (1), p.58-63

2008

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Purification and characterization of recombinant human soluble guanylate cyclase produced from baculovirus-infected insect cells

Protein expression and purification, 2009-06, Vol.65 (2), p.133-139

2009

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Structure of human ADAM-8 catalytic domain complexed with batimastat

Acta crystallographica. Section F, Structural biology and crystallization communications, 2012-06, Vol.68 (6), p.616-621

2012

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A high performance liquid chromatography assay for monitoring proprotein convertase activity

Journal of Chromatography A, 2007-04, Vol.1148 (1), p.46-54

2007

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Mechanism, structure-activity studies, and potential applications of glutathione S-transferase-catalyzed cleavage of sulfonamides

Drug metabolism and disposition, 1999-09, Vol.27 (9), p.992

1999

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An efficient method to express and refold a truncated human procaspase-9: A caspase with activity toward Glu-X bonds

Protein expression and purification, 2006-04, Vol.46 (2), p.299-308

2006

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Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

Journal of medicinal chemistry, 1995-09, Vol.38 (18), p.3624-3637

1995

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Activated sulfonamides are cleaved by glutathione-S-transferases

Drug metabolism and disposition, 1999-09, Vol.27 (9), p.986

1999

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Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

The atomic-resolution structure of human caspase-8, a key activator of apoptosis

Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6

Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Autoactivation of human ADAM8: a novel pre-processing step is required for catalytic activity

Differential kinetics and inhibition of purified recombinant tyrosine kinase 2 (TYK-2) and its catalytic domain JH-1

Employing a superior BACE1 cleavage sequence to probe cellular APP processing

The titerless infected-cells preservation and scale-up (TIPS) method for large-scale production of NO-sensitive human soluble guanylate cyclase (sGC) from insect cells infected with recombinant baculovirus

Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase

Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors

Structure analysis reveals the flexibility of the ADAMTS‐5 active site

ADAM8 substrate specificity: Influence of pH on pre-processing and proteoglycan degradation

Design of potent inhibitors of human β-secretase. Part 1

Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family

Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain

Design of potent inhibitors of human β-secretase. Part 2

High yield purification of soluble guanylate cyclase from bovine lung

Purification and characterization of recombinant human soluble guanylate cyclase produced from baculovirus-infected insect cells

Structure of human ADAM-8 catalytic domain complexed with batimastat

A high performance liquid chromatography assay for monitoring proprotein convertase activity

Mechanism, structure-activity studies, and potential applications of glutathione S-transferase-catalyzed cleavage of sulfonamides

An efficient method to express and refold a truncated human procaspase-9: A caspase with activity toward Glu-X bonds

Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

Activated sulfonamides are cleaved by glutathione-S-transferases

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