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Activation of PPARδ alters lipid metabolism in db/db mice

FEBS letters, 2000-05, Vol.473 (3), p.333-336

2000

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Novel Peroxisome Proliferator-activated Receptor (PPAR) γ and PPARδ Ligands Produce Distinct Biological Effects

The Journal of biological chemistry, 1999-03, Vol.274 (10), p.6718-6725

1999

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Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor

Journal of the American Chemical Society, 1996-03, Vol.118 (10), p.2359-2365

1996

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Phenylacetic acid derivatives as hPPAR agonists

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1277-1280

2003

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5-Aryl thiazolidine-2,4-diones as selective PPARγ agonists

Bioorganic & medicinal chemistry letters, 2003-05, Vol.13 (10), p.1801-1804

2003

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Identification and Selective Inhibition of an Isozyme of Steroid 5α- Reductase in Human Scalp

Proceedings of the National Academy of Sciences - PNAS, 1992-11, Vol.89 (22), p.10787-10791

1992

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Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III

Bioorganic & medicinal chemistry letters, 2001-08, Vol.11 (16), p.2185-2188

2001

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Identification of HIV Vaccine Candidate Peptides by Screening Random Phage Epitope Libraries

Virology (New York, N.Y.), 1993-04, Vol.193 (2), p.709-716

1993

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4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase

Journal of medicinal chemistry, 1994-11, Vol.37 (23), p.3871-3874

1994

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Resolution and stereoselective synthesis of the herpes thymidine kinase inhibitor L-653180

Tetrahedron: asymmetry, 1997-03, Vol.8 (5), p.677-681

1997

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4-Aza-3-oxo-5α-androst-1-ene-17β-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5α-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5α-reductase inhibitory potency

Journal of medicinal chemistry, 1995-08, Vol.38 (17), p.3189-3192

1995

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9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication

Proceedings of the National Academy of Sciences - PNAS, 1983-07, Vol.80 (13), p.4139-4143

1983

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MK386: a potent, selective inhibitor of the human type 1 5α-reductase

The Journal of steroid biochemistry and molecular biology, 1996-07, Vol.58 (4), p.377-384

1996

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Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3845-3857

1992

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Activation by thymidine kinase and potent antiherpetic activity of 2′-nor-2′-deoxyguanosine (2′NDG)

Biochemical and biophysical research communications, 1982-10, Vol.108 (4), p.1716-1721

1982

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4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro]

The Journal of steroid biochemistry and molecular biology, 1997-03, Vol.60 (5), p.303-309

1997

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Immunogenicity of synthetic HIV-1 gp120 V3-loop peptide-conjugate immunogens

Vaccine, 1994, Vol.12 (5), p.445-451

1994

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Avermectins. Structure determination

Journal of the American Chemical Society, 1981-07, Vol.103 (14), p.4216-4221

1981

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Bimolecular chemistry of macromolecules: synthesis of bacterial polysaccharide conjugates with Neisseria meningitidis membrane protein

Journal of the American Chemical Society, 1986-08, Vol.108 (17), p.5282-5287

1986

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Acidic derivatives of homocysteine thiolactone: utility as anionic linkers

Bioconjugate chemistry, 1992-11, Vol.3 (6), p.514-518

1992

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Renin inhibitors containing C-termini derived from mercaptoheterocycles

Journal of medicinal chemistry, 1992-05, Vol.35 (11), p.2103-2112

1992

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SAR for MHC class II binding tetrapeptides: Correlation with potential binding site

Bioorganic & medicinal chemistry letters, 1997-01, Vol.7 (1), p.19-24

1997

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Synthesis and antiherpetic activity of (.+-.)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds

Journal of medicinal chemistry, 1988-12, Vol.31 (12), p.2304-2315

1988

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Assessment of a selective inhibitor of herpes simplex virus thymidine kinase (L-653,180) as therapy for experimental recurrent genital herpes

Antimicrobial Agents and Chemotherapy, 1992-09, Vol.36 (9), p.2020-2024

1992

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Evaluation of retinal toxicity and liposome encapsulation of the anti- CMV drug 2'-nor-cyclic GMP

Investigative ophthalmology & visual science, 1993-09, Vol.34 (10), p.2903-2910

1993

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Activation of PPARδ alters lipid metabolism in db/db mice

Novel Peroxisome Proliferator-activated Receptor (PPAR) γ and PPARδ Ligands Produce Distinct Biological Effects

Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor

Phenylacetic acid derivatives as hPPAR agonists

5-Aryl thiazolidine-2,4-diones as selective PPARγ agonists

Identification and Selective Inhibition of an Isozyme of Steroid 5α- Reductase in Human Scalp

Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III

Identification of HIV Vaccine Candidate Peptides by Screening Random Phage Epitope Libraries

4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase

Resolution and stereoselective synthesis of the herpes thymidine kinase inhibitor L-653180

4-Aza-3-oxo-5α-androst-1-ene-17β-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5α-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5α-reductase inhibitory potency

9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication

MK386: a potent, selective inhibitor of the human type 1 5α-reductase

Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines

Activation by thymidine kinase and potent antiherpetic activity of 2′-nor-2′-deoxyguanosine (2′NDG)

4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro]

Immunogenicity of synthetic HIV-1 gp120 V3-loop peptide-conjugate immunogens

Avermectins. Structure determination

Bimolecular chemistry of macromolecules: synthesis of bacterial polysaccharide conjugates with Neisseria meningitidis membrane protein

Acidic derivatives of homocysteine thiolactone: utility as anionic linkers

Renin inhibitors containing C-termini derived from mercaptoheterocycles

SAR for MHC class II binding tetrapeptides: Correlation with potential binding site

Synthesis and antiherpetic activity of (.+-.)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds

Assessment of a selective inhibitor of herpes simplex virus thymidine kinase (L-653,180) as therapy for experimental recurrent genital herpes

Evaluation of retinal toxicity and liposome encapsulation of the anti- CMV drug 2'-nor-cyclic GMP

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