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Turning the Tide Against Regulatory T Cells

Frontiers in oncology, 2019-04, Vol.9, p.279

2019

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Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.5

Science immunology, 2022-11, Vol.7 (77), p.eade2283

2022

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Immunity against conserved epitopes dominates after two consecutive exposures to SARS-CoV-2 Omicron BA.1

Cell reports (Cambridge), 2024-08, Vol.43 (8), p.114567, Article 114567

2024

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Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells

Frontiers in immunology, 2019-10, Vol.10, p.2382-2382

2019

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Progressive loss of conserved spike protein neutralizing antibody sites in Omicron sublineages is balanced by preserved T cell immunity

Cell reports (Cambridge), 2023-08, Vol.42 (8), p.112888-112888, Article 112888

2023

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Tumor cell expression of B7-H4 correlates with higher frequencies of tumor-infiltrating APCs and higher CXCL17 expression in human epithelial ovarian cancer

Oncoimmunology, 2019-12, Vol.8 (12), p.e1665460-e1665460

2019

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An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation

Oncoimmunology, 2022, Vol.11 (1), p.2030135-2030135

2022

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DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity

Journal for immunotherapy of cancer, 2022-06, Vol.10 (6), p.e004322

2022

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813 Combination of HexaBody-CD27 with PD-(L)1 blockade potentiates single-agent activity leading to enhanced human T-cell effector functions in vitro

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A911-A911

2023

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561 DuoBody®-PD-L1×4–1BB (GEN1046) induces superior immune-cell activation, cytokine production and cytotoxicity by combining PD-L1 blockade with conditional 4–1BB co-stimulation

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A338-A339

2020

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To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms

Science signaling, 2011-02, Vol.4 (158), p.pe4

2011

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WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity

Science (American Association for the Advancement of Science), 2021-03, Vol.371 (6536)

2021

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Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus

The Journal of immunology (1950), 2013-04, Vol.190 (7), p.3180-3188

2013

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Regulatory T cells in ovarian cancer are characterized by a highly activated phenotype distinct from that in melanoma

Clinical cancer research, 2018-11, Vol.24 (22), p.5685-5696

2018

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Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors

Cancer discovery, 2022-05, Vol.12 (5), p.1248-1265

2022

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Abstract 1846: DuoBody-CD40×4-1BB (GEN1042) induces dendritic-cell maturation and enhances T-cell activation and effector functions in vitro by conditional CD40 and 4-1BB agonist activity

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1846-1846

2021

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A signal integration model of thymic selection and natural regulatory T cell commitment

The Journal of immunology (1950), 2014-12, Vol.193 (12), p.5983-5996

2014

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Foxp3+ regulatory T‐cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen

European journal of immunology, 2015-01, Vol.45 (1), p.153-166

2015

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Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells

Oncotarget, 2017-05, Vol.8 (22), p.35542-35557

2017

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Foxp3 super(+) regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen

European journal of immunology, 2015-01, Vol.45 (1), p.153-166

2015

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Abstract 3283: GEN1046 (DuoBody®-PD-L1x4-1BB) in combination with PD-1 blockade potentiates anti-tumor immunity

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.3283-3283

2023

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Naïve blood monocytes suppress T-cell function. A possible mechanism for protection from autoimmunity

Immunology and cell biology, 2011-01, Vol.89 (1), p.7-13

2011

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Signal integration in thymocytes is crucial for thymic selection

Frontiers in immunology, 2013, Vol.4

2013

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A modified superantigen rescues Ly6G − CD11b + blood monocyte suppressor function and suppresses antigen-specific inflammation in EAE

Autoimmunity (Chur, Switzerland), 2013-06, Vol.46 (4), p.269-278

2013

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Turning the Tide Against Regulatory T Cells

Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.5

Immunity against conserved epitopes dominates after two consecutive exposures to SARS-CoV-2 Omicron BA.1

Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells

Progressive loss of conserved spike protein neutralizing antibody sites in Omicron sublineages is balanced by preserved T cell immunity

Tumor cell expression of B7-H4 correlates with higher frequencies of tumor-infiltrating APCs and higher CXCL17 expression in human epithelial ovarian cancer

An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation

DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity

813 Combination of HexaBody-CD27 with PD-(L)1 blockade potentiates single-agent activity leading to enhanced human T-cell effector functions in vitro

561 DuoBody®-PD-L1×4–1BB (GEN1046) induces superior immune-cell activation, cytokine production and cytotoxicity by combining PD-L1 blockade with conditional 4–1BB co-stimulation

To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms

WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity

Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus

Regulatory T cells in ovarian cancer are characterized by a highly activated phenotype distinct from that in melanoma

Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors

Abstract 1846: DuoBody-CD40×4-1BB (GEN1042) induces dendritic-cell maturation and enhances T-cell activation and effector functions in vitro by conditional CD40 and 4-1BB agonist activity

A signal integration model of thymic selection and natural regulatory T cell commitment

Foxp3+ regulatory T‐cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen

Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells

Foxp3 super(+) regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen

Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice

Abstract 3283: GEN1046 (DuoBody®-PD-L1x4-1BB) in combination with PD-1 blockade potentiates anti-tumor immunity

Naïve blood monocytes suppress T-cell function. A possible mechanism for protection from autoimmunity

Signal integration in thymocytes is crucial for thymic selection

A modified superantigen rescues Ly6G − CD11b + blood monocyte suppressor function and suppresses antigen-specific inflammation in EAE

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