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Bispecific and trispecific killer cell engagers directly activate human NK cells through CD16 signaling and induce cytotoxicity and cytokine production

Molecular cancer therapeutics, 2012-12, Vol.11 (12), p.2674-2684

2012

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A tri-specific killer engager against mesothelin targets NK cells towards lung cancer

Frontiers in immunology, 2023-02, Vol.14, p.1060905-1060905

2023

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Development of a Deimmunized Bispecific Immunotoxin dDT2219 against B-Cell Malignancies

Toxins, 2018-01, Vol.10 (1), p.32

2018

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Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development

Toxins, 2015-10, Vol.7 (10), p.4067-4082

2015

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A Bispecific Recombinant Immunotoxin, DT2219, Targeting Human CD19 and CD22 Receptors in a Mouse Xenograft Model of B-Cell Leukemia/Lymphoma

Clinical cancer research, 2005-05, Vol.11 (10), p.3879-3888

2005

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A deimmunized bispecific ligand-directed toxin that shows an impressive anti-pancreatic cancer effect in a systemic nude mouse orthotopic model

Pancreas, 2012-07, Vol.41 (5), p.789-796

2012

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Intracranial elimination of human glioblastoma brain tumors in nude rats using the bispecific ligand-directed toxin, DTEGF13 and convection enhanced delivery

Journal of neuro-oncology, 2009-12, Vol.95 (3), p.331-342

2009

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A bispecific immunotoxin (DTAT13) targeting human IL‐13 receptor (IL‐13R) and urokinase‐type plasminogen activator receptor (uPAR) in a mouse xenograft model

Protein engineering, design and selection, 2004-02, Vol.17 (2), p.157-164

2004

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Intracranial therapy of glioblastoma with the fusion protein DTIL13 in immunodeficient mice

International journal of cancer, 2006-05, Vol.118 (10), p.2594-2601

2006

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Intracranial therapy of glioblastoma with the fusion protein DTAT in immunodeficient mice

International journal of cancer, 2007-01, Vol.120 (2), p.411-419

2007

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Immunotoxin pharmacokinetics : a comparison of the anti-glioblastoma bi-specific fusion protein (DTAT13) to DTAT and DTIL13

Journal of neuro-oncology, 2006-05, Vol.77 (3), p.257-266

2006

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Tetraspecific scFv construct provides NK cell mediated ADCC and self-sustaining stimuli via insertion of IL-15 as a cross-linker

Oncotarget, 2016-11, Vol.7 (45), p.73830-73844

2016

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Targeting glioblastoma multiforme with an IL-13/diphtheria toxin fusion protein in vitro and in vivo in nude mice

Protein engineering, 2002-05, Vol.15 (5), p.419-427

2002

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Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR

Molecular cancer therapeutics, 2017-05, Vol.16 (5), p.956-965

2017

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Targeting EGFR and uPAR on human rhabdomyosarcoma, osteosarcoma, and ovarian adenocarcinoma with a bispecific ligand-directed toxin

Clinical pharmacology: advances and applications, 2018-01, Vol.10, p.113-121

2018

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Impact of repeated cycles of EGF bispecific angiotoxin (eBAT) administered at a reduced interval from doxorubicin chemotherapy in dogs with splenic haemangiosarcoma

Veterinary & comparative oncology, 2020-12, Vol.18 (4), p.664-674

2020

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CD16-IL15-CD33 Trispecific Killer Engager (TriKE) induces NK cell expansion, persistence, and myeloid blast antigen specific killing

The Journal of immunology (1950), 2016-05, Vol.196 (1_Supplement), p.75-75.8

2016

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Impact of Repeated Cycles of EGF Bispecific Angiotoxin (eBAT) Administered at a Reduced Interval from Doxorubicin Chemotherapy in Dogs with Splenic Hemangiosarcoma

Veterinary & comparative oncology, 2020-04, Vol.18 (4), p.664-674

2020

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Molecular modification of a recombinant, bivalent anti-human CD3 immunotoxin (Bic3) results in reduced in vivo toxicity in mice

Leukemia research, 2005-03, Vol.29 (3), p.331-341

2005

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Gram-negative bacterial infections of the mammary gland in cows

American journal of veterinary research, 1991-02, Vol.52 (2), p.184

1991

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Growth of gram-negative bacteria in dry cow secretion

Journal of dairy science, 1990-02, Vol.73 (2), p.363-372

1990

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Intramammary Challenge of the Bovine Mammary Gland with Coliform Bacteria During Early Involution1

Journal of dairy science, 1990-05, Vol.73 (5), p.1217-1224

1990

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Growth of Gram-Negative Bacteria in Dry Cow Secretion1

Journal of dairy science, 1990-02, Vol.73 (2), p.363-372

1990

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Pathogenesis of coliform bacteria in the nonlactating bovine mammary gland

Todhunter, Deborah Ann

1989

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ProQuest

Intramammary challenge of the bovine mammary gland with coliform bacteria during early involution

Journal of dairy science, 1990-05, Vol.73 (5), p.1217-1224

1990

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Bispecific and trispecific killer cell engagers directly activate human NK cells through CD16 signaling and induce cytotoxicity and cytokine production

A tri-specific killer engager against mesothelin targets NK cells towards lung cancer

Development of a Deimmunized Bispecific Immunotoxin dDT2219 against B-Cell Malignancies

Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development

A Bispecific Recombinant Immunotoxin, DT2219, Targeting Human CD19 and CD22 Receptors in a Mouse Xenograft Model of B-Cell Leukemia/Lymphoma

A deimmunized bispecific ligand-directed toxin that shows an impressive anti-pancreatic cancer effect in a systemic nude mouse orthotopic model

Intracranial elimination of human glioblastoma brain tumors in nude rats using the bispecific ligand-directed toxin, DTEGF13 and convection enhanced delivery

A bispecific immunotoxin (DTAT13) targeting human IL‐13 receptor (IL‐13R) and urokinase‐type plasminogen activator receptor (uPAR) in a mouse xenograft model

Intracranial therapy of glioblastoma with the fusion protein DTIL13 in immunodeficient mice

Intracranial therapy of glioblastoma with the fusion protein DTAT in immunodeficient mice

Immunotoxin pharmacokinetics : a comparison of the anti-glioblastoma bi-specific fusion protein (DTAT13) to DTAT and DTIL13

Tetraspecific scFv construct provides NK cell mediated ADCC and self-sustaining stimuli via insertion of IL-15 as a cross-linker

Targeting glioblastoma multiforme with an IL-13/diphtheria toxin fusion protein in vitro and in vivo in nude mice

Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR

Targeting EGFR and uPAR on human rhabdomyosarcoma, osteosarcoma, and ovarian adenocarcinoma with a bispecific ligand-directed toxin

Impact of repeated cycles of EGF bispecific angiotoxin (eBAT) administered at a reduced interval from doxorubicin chemotherapy in dogs with splenic haemangiosarcoma

CD16-IL15-CD33 Trispecific Killer Engager (TriKE) induces NK cell expansion, persistence, and myeloid blast antigen specific killing

Impact of Repeated Cycles of EGF Bispecific Angiotoxin (eBAT) Administered at a Reduced Interval from Doxorubicin Chemotherapy in Dogs with Splenic Hemangiosarcoma

Molecular modification of a recombinant, bivalent anti-human CD3 immunotoxin (Bic3) results in reduced in vivo toxicity in mice

Gram-negative bacterial infections of the mammary gland in cows

Growth of gram-negative bacteria in dry cow secretion

Intramammary Challenge of the Bovine Mammary Gland with Coliform Bacteria During Early Involution1

Growth of Gram-Negative Bacteria in Dry Cow Secretion1

Pathogenesis of coliform bacteria in the nonlactating bovine mammary gland

Intramammary challenge of the bovine mammary gland with coliform bacteria during early involution

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