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Can in vitro drug metabolism studies with human tissue replace in vivo animal studies?

Environmental toxicology and pharmacology, 2006-02, Vol.21 (2), p.184-190

2006

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Bioavailability and pharmacokinetics of a praziquantel bolus in kingfish Seriola lalandi

Diseases of aquatic organisms, 2006-04, Vol.69 (2-3), p.233-238

2006

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Reversible binding of the novel anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid to plasma proteins and its distribution into blood cells in various species

Journal of pharmacy and pharmacology, 2001-04, Vol.53 (4), p.463-471

2001

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Varenicline improves motor and cognitive symptoms in early Huntington's disease

Neuropsychiatric disease and treatment, 2016-01, Vol.12, p.2381-2386

2016

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Satraplatin activation by haemoglobin, cytochrome C and liver microsomes in vitro

Cancer chemotherapy and pharmacology, 2006-04, Vol.57 (4), p.483-490

2006

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Comparative bioactivation of the novel anti‐tuberculosis agent PA‐824 in Mycobacteria and a subcellular fraction of human liver

British journal of pharmacology, 2011-01, Vol.162 (1), p.226-236

2011

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Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption

Human reproduction (Oxford), 2002-10, Vol.17 (10), p.2564-2572

2002

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Effect of dose escalation on multiple dose pharmacokinetics of orally administered praziquantel in kingfish Seriola lalandi

Aquaculture, 2006-12, Vol.261 (4), p.1168-1174

2006

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Febrile Seizures: Risks, Evaluation, and Prognosis

American family physician, 2012-01, Vol.85 (2), p.149-153

2012

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UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term

Biochemical pharmacology, 2002-02, Vol.63 (3), p.409-419

2002

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Rapid biotransformation of satraplatin by human red blood cells in vitro

Cancer chemotherapy and pharmacology, 2002-07, Vol.50 (1), p.9-15

2002

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A highly sensitive fluorescent microplate method for the determination of UDP-glucuronosyl transferase activity in tissues and placental cell lines

Drug metabolism and disposition, 2000-10, Vol.28 (10), p.1184

2000

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Identification of the human liver cytochrome P450 isoenzyme responsible for the 6-methylhydroxylation of the novel anticancer drug 5,6-dimethylxanthenone-4-acetic acid

Drug metabolism and disposition, 2000-12, Vol.28 (12), p.1449

2000

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Aerobic 2- and 4-nitroreduction of CB 1954 by human liver

Toxicology (Amsterdam), 2005-12, Vol.216 (2), p.129-139

2005

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Hepatic nitroreduction, toxicity and toxicokinetics of the anti-tumour prodrug CB 1954 in mouse and rat

Toxicology (Amsterdam), 2007-10, Vol.240 (1), p.70-85

2007

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3′-Azido-3′-deoxythymidine (AZT) induces apoptosis and alters metabolic enzyme activity in human placenta

Toxicology and applied pharmacology, 2003-10, Vol.192 (2), p.164-173

2003

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N‐Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity

British journal of clinical pharmacology, 1995-12, Vol.40 (6), p.531-538

1995

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An investigation of the role of metabolism in dapsone‐induced methaemoglobinaemia using a two compartment in vitro test system

British journal of clinical pharmacology, 1990-12, Vol.30 (6), p.829-838

1990

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Comparison of the metabolism and toxicity of dapsone in rat, mouse and man

The Journal of pharmacology and experimental therapeutics, 1997-11, Vol.283 (2), p.817

1997

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Cimetidine improves the therapeutic/toxic ratio of dapsone in patients on chronic dapsone therapy

British journal of dermatology (1951), 1995-02, Vol.132 (2), p.257-262

1995

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Species differences in the metabolism of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid in vitro : implications for prediction of metabolic interactions in vivo

Xenobiotica, 2002-02, Vol.32 (2), p.87-107

2002

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The use of a three compartment in vitro model to investigate the role of hepatic drug metabolism in drug‐induced blood dyscrasias

British journal of clinical pharmacology, 1993-07, Vol.36 (1), p.31-38

1993

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Identification and reactivity of the major metabolite (ß-1-glucuronide) of the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in humans

Xenobiotica, 2001-05, Vol.31 (5), p.277-293

2001

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The bioactivation of amodiaquine by human polymorphonuclear leukocytes in vitro : chemical mechanisms and the effects of fluorine substitution

Biochemical pharmacology, 1995-09, Vol.50 (7), p.1113-1119

1995

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Effects of anticancer drugs on the metabolism of the anticancer drug 5,6‐dimethylxanthenone‐4‐acetic (DMXAA) by human liver microsomes

British journal of clinical pharmacology, 2001-08, Vol.52 (2), p.129-136

2001

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Can in vitro drug metabolism studies with human tissue replace in vivo animal studies?

Bioavailability and pharmacokinetics of a praziquantel bolus in kingfish Seriola lalandi

Reversible binding of the novel anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid to plasma proteins and its distribution into blood cells in various species

Varenicline improves motor and cognitive symptoms in early Huntington's disease

Satraplatin activation by haemoglobin, cytochrome C and liver microsomes in vitro

Comparative bioactivation of the novel anti‐tuberculosis agent PA‐824 in Mycobacteria and a subcellular fraction of human liver

Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption

Effect of dose escalation on multiple dose pharmacokinetics of orally administered praziquantel in kingfish Seriola lalandi

Febrile Seizures: Risks, Evaluation, and Prognosis

UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term

Rapid biotransformation of satraplatin by human red blood cells in vitro

A highly sensitive fluorescent microplate method for the determination of UDP-glucuronosyl transferase activity in tissues and placental cell lines

Identification of the human liver cytochrome P450 isoenzyme responsible for the 6-methylhydroxylation of the novel anticancer drug 5,6-dimethylxanthenone-4-acetic acid

Aerobic 2- and 4-nitroreduction of CB 1954 by human liver

Hepatic nitroreduction, toxicity and toxicokinetics of the anti-tumour prodrug CB 1954 in mouse and rat

3′-Azido-3′-deoxythymidine (AZT) induces apoptosis and alters metabolic enzyme activity in human placenta

N‐Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity

An investigation of the role of metabolism in dapsone‐induced methaemoglobinaemia using a two compartment in vitro test system

Comparison of the metabolism and toxicity of dapsone in rat, mouse and man

Cimetidine improves the therapeutic/toxic ratio of dapsone in patients on chronic dapsone therapy

Species differences in the metabolism of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid in vitro : implications for prediction of metabolic interactions in vivo

The use of a three compartment in vitro model to investigate the role of hepatic drug metabolism in drug‐induced blood dyscrasias

Identification and reactivity of the major metabolite (ß-1-glucuronide) of the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in humans

The bioactivation of amodiaquine by human polymorphonuclear leukocytes in vitro : chemical mechanisms and the effects of fluorine substitution

Effects of anticancer drugs on the metabolism of the anticancer drug 5,6‐dimethylxanthenone‐4‐acetic (DMXAA) by human liver microsomes

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