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Maturation of beta cells: lessons from in vivo and in vitro models

Diabetologia, 2022-06, Vol.65 (6), p.917-930

2022

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Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

eLife, 2018-11, Vol.7

2018

Volltextzugriff (PDF)

Human pluripotent reprogramming with CRISPR activators

Nature communications, 2018-07, Vol.9 (1), p.2643-12, Article 2643

2018

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Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

Nature biotechnology, 2022-07, Vol.40 (7), p.1042-1055

2022

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Stem Cell Based Models in Congenital Hyperinsulinism - Perspective on Practicalities and Possibilities

Frontiers in endocrinology (Lausanne), 2022-02, Vol.13, p.837450-837450

2022

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Tissue- and cell-type–specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (38), p.E3622-E3630

2013

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Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

Nature communications, 2019-02, Vol.10 (1), p.620-620, Article 620

2019

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Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation

Stem cell reports, 2015-09, Vol.5 (3), p.448-459

2015

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Copy number variation and selection during reprogramming to pluripotency

Nature (London), 2011-03, Vol.471 (7336), p.58-62

2011

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Human pluripotent stem cell based islet models for diabetes research

Best Practice & Research Clinical Endocrinology & Metabolism, 2015-12, Vol.29 (6), p.899-909

2015

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Metabolic determination of cell fate through selective inheritance of mitochondria

Nature cell biology, 2022-02, Vol.24 (2), p.148

2022

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SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism

Diabetologia, 2021-03, Vol.64 (3), p.630-640

2021

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MANF protects human pancreatic beta cells against stress-induced cell death

Diabetologia, 2018-10, Vol.61 (10), p.2202-2214

2018

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Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress

Diabetes (New York, N.Y.), 2021-04, Vol.70 (4), p.1006-1018

2021

Volltextzugriff (PDF)

IL-17 immunity in human type 1 diabetes

The Journal of immunology (1950), 2010-08, Vol.185 (3), p.1959-1967

2010

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GAD65 Antigen Therapy in Recently Diagnosed Type 1 Diabetes Mellitus

The New England journal of medicine, 2012-02, Vol.366 (5), p.433-442

2012

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MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells

Cell reports (Cambridge), 2014-04, Vol.7 (2), p.366-375

2014

Volltextzugriff (PDF)

The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

Nature communications, 2022-10, Vol.13 (1), p.6363-6363, Article 6363

2022

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In vitro beta-cell killing models using immune cells and human pluripotent stem cell-derived islets: Challenges and opportunities

Frontiers in endocrinology (Lausanne), 2023-01, Vol.13, p.1076683-1076683

2023

Volltextzugriff (PDF)

High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity

Nature biotechnology, 2010-04, Vol.28 (4), p.371-377

2010

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Combined negative effect of donor age and time in culture on the reprogramming efficiency into induced pluripotent stem cells

Stem cell research, 2015-07, Vol.15 (1), p.254-262

2015

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Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential

Stem cell reports, 2016-02, Vol.6 (2), p.200-212

2016

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ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons

Neurobiology of disease, 2020-07, Vol.141, p.104940-104940, Article 104940

2020

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An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

Cell reports (Cambridge), 2017-04, Vol.19 (2), p.281-294

2017

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Aberrant metabolite trafficking and fuel sensitivity in human pluripotent stem cell-derived islets

Cell reports (Cambridge), 2023-08, Vol.42 (8), p.112970-112970, Article 112970

2023

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Maturation of beta cells: lessons from in vivo and in vitro models

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

Human pluripotent reprogramming with CRISPR activators

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

Stem Cell Based Models in Congenital Hyperinsulinism - Perspective on Practicalities and Possibilities

Tissue- and cell-type–specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation

Copy number variation and selection during reprogramming to pluripotency

Human pluripotent stem cell based islet models for diabetes research

Metabolic determination of cell fate through selective inheritance of mitochondria

SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism

MANF protects human pancreatic beta cells against stress-induced cell death

Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress

IL-17 immunity in human type 1 diabetes

GAD65 Antigen Therapy in Recently Diagnosed Type 1 Diabetes Mellitus

MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells

The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

In vitro beta-cell killing models using immune cells and human pluripotent stem cell-derived islets: Challenges and opportunities

High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity

Combined negative effect of donor age and time in culture on the reprogramming efficiency into induced pluripotent stem cells

Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential

ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

Aberrant metabolite trafficking and fuel sensitivity in human pluripotent stem cell-derived islets

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