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Mouse Models of Cardiomyopathies Caused by Mutations in Troponin C

International journal of molecular sciences, 2023-08, Vol.24 (15), p.12349

2023

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Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure–Activity Relationship

Journal of chemical information and modeling, 2023-06, Vol.63 (11), p.3462-3473

2023

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Photorhabdus luminescens TccC3 Toxin Targets the Dynamic Population of F-Actin and Impairs Cell Cortex Integrity

International journal of molecular sciences, 2022-06, Vol.23 (13), p.7026

2022

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Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin‐Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

Journal of the American Heart Association, 2018-05, Vol.7 (10), p.n/a

2018

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Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates

PloS one, 2012-06, Vol.7 (6), p.e38259

2012

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Discovery of Novel Small-Molecule Calcium Sensitizers for Cardiac Troponin C: A Combined Virtual and Experimental Screening Approach

Journal of chemical information and modeling, 2020-07, Vol.60 (7), p.3648-3661

2020

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Designing Calcium-sensitizing Mutations in the Regulatory Domain of Cardiac Troponin C

The Journal of biological chemistry, 2004-08, Vol.279 (34), p.35341-35352

2004

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Hypertrophic Cardiomyopathy-Linked Mutation D145E Drastically Alters Calcium Binding by the C-Domain of Cardiac Troponin C

Biochemistry (Easton), 2010-06, Vol.49 (23), p.4813-4820

2010

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Successful Identification of Cardiac Troponin Calcium Sensitizers Using a Combination of Virtual Screening and ROC Analysis of Known Troponin C Binders

Journal of chemical information and modeling, 2017-12, Vol.57 (12), p.3056-3069

2017

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Ca(2+) exchange with troponin C and cardiac muscle dynamics

Cardiovascular research, 2008-03, Vol.77 (4), p.619-626

2008

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3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP

The Journal of general physiology, 2019-01, Vol.151 (1), p.9-17

2019

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Measurement of calcium dissociation rates from troponin C in rigor skeletal myofibrils

Frontiers in physiology, 2011-01, Vol.2, p.70-70

2011

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Engineered Troponin C Constructs Correct Disease-related Cardiac Myofilament Calcium Sensitivity

The Journal of biological chemistry, 2012-06, Vol.287 (24), p.20027-20036

2012

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Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I

Frontiers in physiology, 2016-12, Vol.7, p.632-632

2016

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Designing proteins to combat disease: Cardiac troponin C as an example

Archives of biochemistry and biophysics, 2016-07, Vol.601, p.4-10

2016

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Effects of Thin and Thick Filament Proteins on Calcium Binding and Exchange with Cardiac Troponin C

Biophysical journal, 2007-05, Vol.92 (9), p.3195-3206

2007

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Engineering Competitive Magnesium Binding into the First EF-hand of Skeletal Troponin C

The Journal of biological chemistry, 2002-12, Vol.277 (51), p.49716-49726

2002

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Molecular and functional consequences of mutations in the central helix of cardiac troponin C

Archives of biochemistry and biophysics, 2014-04, Vol.548, p.46-53

2014

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Influence of enhanced troponin C Ca2+-binding affinity on cooperative thin filament activation in rabbit skeletal muscle

The Journal of physiology, 2007-08, Vol.583 (1), p.337-350

2007

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Effect of Calcium-Sensitizing Mutations on Calcium Binding and Exchange with Troponin C in Increasingly Complex Biochemical Systems

Biochemistry (Easton), 2010-03, Vol.49 (9), p.1975-1984

2010

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Effect of Hypertrophic Cardiomyopathy-Linked Troponin C Mutations on the Response of Reconstituted Thin Filaments to Calcium upon Troponin I Phosphorylation

Biochemistry (Easton), 2012-05, Vol.51 (17), p.3614-3621

2012

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Divergent Soybean Calmodulins Respond Similarly to Calcium Transients: Insight into Differential Target Regulation

Frontiers in plant science, 2017-02, Vol.8, p.208-208

2017

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Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy

Frontiers in physiology, 2015, Vol.6, p.242

2015

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Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart

The Journal of biological chemistry, 2004-11, Vol.279 (48), p.49579-49587

2004

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Modulation of the rate of cardiac muscle contraction by troponin C constructs with various calcium binding affinities

American journal of physiology. Heart and circulatory physiology, 2007-10, Vol.293 (4), p.H2580-H2587

2007

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Mouse Models of Cardiomyopathies Caused by Mutations in Troponin C

Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure–Activity Relationship

Photorhabdus luminescens TccC3 Toxin Targets the Dynamic Population of F-Actin and Impairs Cell Cortex Integrity

Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin‐Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates

Discovery of Novel Small-Molecule Calcium Sensitizers for Cardiac Troponin C: A Combined Virtual and Experimental Screening Approach

Designing Calcium-sensitizing Mutations in the Regulatory Domain of Cardiac Troponin C

Hypertrophic Cardiomyopathy-Linked Mutation D145E Drastically Alters Calcium Binding by the C-Domain of Cardiac Troponin C

Successful Identification of Cardiac Troponin Calcium Sensitizers Using a Combination of Virtual Screening and ROC Analysis of Known Troponin C Binders

Ca(2+) exchange with troponin C and cardiac muscle dynamics

3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP

Measurement of calcium dissociation rates from troponin C in rigor skeletal myofibrils

Engineered Troponin C Constructs Correct Disease-related Cardiac Myofilament Calcium Sensitivity

Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I

Designing proteins to combat disease: Cardiac troponin C as an example

Effects of Thin and Thick Filament Proteins on Calcium Binding and Exchange with Cardiac Troponin C

Engineering Competitive Magnesium Binding into the First EF-hand of Skeletal Troponin C

Molecular and functional consequences of mutations in the central helix of cardiac troponin C

Influence of enhanced troponin C Ca2+-binding affinity on cooperative thin filament activation in rabbit skeletal muscle

Effect of Calcium-Sensitizing Mutations on Calcium Binding and Exchange with Troponin C in Increasingly Complex Biochemical Systems

Effect of Hypertrophic Cardiomyopathy-Linked Troponin C Mutations on the Response of Reconstituted Thin Filaments to Calcium upon Troponin I Phosphorylation

Divergent Soybean Calmodulins Respond Similarly to Calcium Transients: Insight into Differential Target Regulation

Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy

Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart

Modulation of the rate of cardiac muscle contraction by troponin C constructs with various calcium binding affinities

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