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Ibuprofen inhibits rat brain deamidation of anandamide at pharmacologically relevant concentrations. Mode of inhibition and structure-activity relationship

The Journal of pharmacology and experimental therapeutics, 1997-11, Vol.283 (2), p.729

1997

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Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide11Abbreviations: AEA, anandamide, arachidonyl ethanolamide; PEA, palmitoylethanolamide, N-(2-hydroxyethyl) hexadecamide; FAAH, fatty acid amide hydrolase; CB, cannabinoid; PMSF, phenylmethylsulfonyl fluoride; MAFP, methyl arachidonyl fluorophosphonate; methAEA, arachidonyl-1′-hydroxy-2′-propylamide; and NSAIDs, nons

Biochemical pharmacology, 2001-09, Vol.62 (5), p.517-526

2001

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Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide

Biochemical pharmacology, 2001-09, Vol.62 (5), p.517-526

2001

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Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2‐arachidonoylglycerol

British journal of pharmacology, 2004-11, Vol.143 (6), p.774-784

2004

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Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis—a difficult issue to handle

European journal of pharmacology, 2004-05, Vol.492 (1), p.1-11

2004

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Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide

British journal of pharmacology, 2001-08, Vol.133 (8), p.1263-1275

2001

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The endocannabinoid signaling system: Pharmacological and therapeutic aspects

Pharmacology, biochemistry and behavior, 2005-06, Vol.81 (2), p.248-262

2005

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Design, Synthesis, and Biological Evaluation of New Inhibitors of the Endocannabinoid Uptake: Comparison with Effects on Fatty Acid Amidohydrolase

Journal of medicinal chemistry, 2003-04, Vol.46 (8), p.1512-1522

2003

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Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro

Biochemical pharmacology, 2005-04, Vol.69 (8), p.1241-1245

2005

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Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability

Biochemical pharmacology, 2000-12, Vol.60 (12), p.1807-1813

2000

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Differences in the pharmacological properties of rat and chicken brain fatty acid amidohydrolase

British journal of pharmacology, 2000-10, Vol.131 (3), p.498-504

2000

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Acidic Nonsteroidal Anti-inflammatory Drugs Inhibit Rat Brain Fatty Acid Amide Hydrolase in a pH-dependent Manner

Journal of enzyme inhibition and medicinal chemistry, 2003-01, Vol.18 (1), p.55-58

2003

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Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors

European journal of medicinal chemistry, 2003-04, Vol.38 (4), p.403-412

2003

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Effects of pH on the inhibition of fatty acid amidohydrolase by ibuprofen

British journal of pharmacology, 2001-06, Vol.133 (4), p.513-520

2001

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Inhibition of Anandamide Hydrolysis by the Enantiomers of Ibuprofen, Ketorolac, and Flurbiprofen

Archives of biochemistry and biophysics, 1999-02, Vol.362 (2), p.191-196

1999

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Serotonin-Stimulated Calcium Responses in Human Platelets

Cellular signalling, 1998-09, Vol.10 (8), p.561-568

1998

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The Sulphydryl Oxidizing Reagent Diamide Affects Phosphoinositide-Mediated Signal Transduction

Cellular signalling, 1998-06, Vol.10 (6), p.399-406

1998

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Pharmacological properties of rat brain fatty acid amidohydrolase in different subcellular fractions using palmitoylethanolamide as substrate

Biochemical pharmacology, 2000-03, Vol.59 (6), p.647-653

2000

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Serotonin stimulation of calcium mobilisation in human platelets: choice of units of measurement, effects of age and tobacco use, and correlation with serotonin 2A receptor density

Clinica chimica acta, 1999, Vol.287 (1), p.1-18

1999

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Mechanisms of Local Anesthetic Action

Anesthesia and analgesia, 1996-03, Vol.82 (3), p.673-674

1996

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Calibration of Fura-2 signals introduces errors into measurement of thrombin-stimulated calcium mobilisation in human platelets

Clinica chimica acta, 1997-09, Vol.265 (2), p.247-261

1997

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Inhibition of Fatty Acid Amidohydrolase, the Enzyme Responsible for the Metabolism of the Endocannabinoid Anandamide, by Analogues of Arachidonoyl-serotonin

Journal of enzyme inhibition and medicinal chemistry, 2003-06, Vol.18 (3), p.225-231

2003

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Effects of pH on the inhibition of fatty acid amidohydrolase by ibuprofen

British journal of pharmacology, 2001-09, Vol.134 (2), p.451-451

2001

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Serotonin-Stimulated Calcium Responses in Human Platelets: Assay Buffer Dependency

Cellular signalling, 1998-09, Vol.10 (8), p.561-568

1998

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Comparison of the Binding Activities of Some Drugs on α2A, α2B and α2C‐Adrenoceptors and Non‐Adrenergic Imidazoline Sites in the Guinea Pig

Pharmacology & toxicology, 1995-06, Vol.76 (6), p.353-364

1995

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Ibuprofen inhibits rat brain deamidation of anandamide at pharmacologically relevant concentrations. Mode of inhibition and structure-activity relationship

Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide

Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2‐arachidonoylglycerol

Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis—a difficult issue to handle

Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide

The endocannabinoid signaling system: Pharmacological and therapeutic aspects

Design, Synthesis, and Biological Evaluation of New Inhibitors of the Endocannabinoid Uptake: Comparison with Effects on Fatty Acid Amidohydrolase

Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro

Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability

Differences in the pharmacological properties of rat and chicken brain fatty acid amidohydrolase

Acidic Nonsteroidal Anti-inflammatory Drugs Inhibit Rat Brain Fatty Acid Amide Hydrolase in a pH-dependent Manner

Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors

Effects of pH on the inhibition of fatty acid amidohydrolase by ibuprofen

Inhibition of Anandamide Hydrolysis by the Enantiomers of Ibuprofen, Ketorolac, and Flurbiprofen

Serotonin-Stimulated Calcium Responses in Human Platelets

The Sulphydryl Oxidizing Reagent Diamide Affects Phosphoinositide-Mediated Signal Transduction

Pharmacological properties of rat brain fatty acid amidohydrolase in different subcellular fractions using palmitoylethanolamide as substrate

Serotonin stimulation of calcium mobilisation in human platelets: choice of units of measurement, effects of age and tobacco use, and correlation with serotonin 2A receptor density

Mechanisms of Local Anesthetic Action

Calibration of Fura-2 signals introduces errors into measurement of thrombin-stimulated calcium mobilisation in human platelets

Inhibition of Fatty Acid Amidohydrolase, the Enzyme Responsible for the Metabolism of the Endocannabinoid Anandamide, by Analogues of Arachidonoyl-serotonin

Effects of pH on the inhibition of fatty acid amidohydrolase by ibuprofen

Serotonin-Stimulated Calcium Responses in Human Platelets: Assay Buffer Dependency

Comparison of the Binding Activities of Some Drugs on α2A, α2B and α2C‐Adrenoceptors and Non‐Adrenergic Imidazoline Sites in the Guinea Pig

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