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The use of spirocyclic scaffolds in drug discovery

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (16), p.3673-3682

2014

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The utilization of spirocyclic scaffolds in novel drug discovery

Expert opinion on drug discovery, 2016-09, Vol.11 (9), p.831-834

2016

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The Medicinal Chemistry of Liver X Receptor (LXR) Modulators

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7182-7205

2014

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Selecting the right compounds for screening: does Lipinski's Rule of 5 for pharmaceuticals apply to agrochemicals?

Pest management science, 2001-01, Vol.57 (1), p.3-16

Tice, Colin M

2001

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Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor

Viruses, 2022-09, Vol.14 (9), p.2025

2022

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Conformational control in structure-based drug design

Bioorganic & medicinal chemistry letters, 2017-07, Vol.27 (13), p.2825-2837

2017

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Structure based design of 11β-HSD1 inhibitors

Current pharmaceutical biotechnology, 2010-11, Vol.11 (7), p.779

2010

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PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication

Cell chemical biology, 2024-04, Vol.31 (4), p.658-668.e14

2024

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Non-canonical modulators of nuclear receptors

Bioorganic & medicinal chemistry letters, 2016-09, Vol.26 (17), p.4157-4164

2016

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Optimization of orally bioavailable alkyl amine renin inhibitors

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.694-699

2010

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Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist

Journal of medicinal chemistry, 2016-04, Vol.59 (7), p.3264-3271

2016

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Tight-Binding Hydroxypyrazole HIV‑1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC‑I Downregulation

ACS infectious diseases, 2020-02, Vol.6 (2), p.302-312

2020

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Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor

Bioorganic & medicinal chemistry, 2017-07, Vol.25 (14), p.3649-3657

2017

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Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (20), p.5044-5050

2016

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Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1

Journal of medicinal chemistry, 2011-09, Vol.54 (17), p.6050-6062

2011

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Selecting the right compounds for screening: use of surface-area parameters

Pest management science, 2002-03, Vol.58 (3), p.219-233

Tice, Colin M

2002

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Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility

ACS medicinal chemistry letters, 2011-10, Vol.2 (10), p.747-751

2011

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Spirocyclic ureas: Orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.881-886

2010

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Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket

Bioorganic & medicinal chemistry letters, 2011-08, Vol.21 (16), p.4836-4843

2011

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Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6725-6729

2010

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Design and optimization of renin inhibitors: Orally bioavailable alkyl amines

Bioorganic & medicinal chemistry, 2009-07, Vol.19 (13), p.3541-3545

2009

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Highly flexible ligand binding pocket of ecdysone receptor: a single amino acid change leads to discrimination between two groups of nonsteroidal ecdysone agonists

The Journal of biological chemistry, 2004-06, Vol.279 (26), p.27211-27218

2004

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Synthesis and SAR of cis-1-Benzoyl-1,2,3,4-tetrahydroquinoline ligands for control of gene expression in ecdysone responsive systems

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (11), p.1943-1946

2003

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Optimization of α-acylaminoketone ecdysone agonists for control of gene expression

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (11), p.1883-1886

2003

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Synthesis and SAR of α-Acylaminoketone ligands for control of gene expression

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (3), p.475-478

2003

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The use of spirocyclic scaffolds in drug discovery

The utilization of spirocyclic scaffolds in novel drug discovery

The Medicinal Chemistry of Liver X Receptor (LXR) Modulators

Selecting the right compounds for screening: does Lipinski's Rule of 5 for pharmaceuticals apply to agrochemicals?

Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor

Conformational control in structure-based drug design

Structure based design of 11β-HSD1 inhibitors

PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication

Non-canonical modulators of nuclear receptors

Optimization of orally bioavailable alkyl amine renin inhibitors

Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist

Tight-Binding Hydroxypyrazole HIV‑1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC‑I Downregulation

Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor

Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core

Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1

Selecting the right compounds for screening: use of surface-area parameters

Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility

Spirocyclic ureas: Orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design

Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket

Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1

Design and optimization of renin inhibitors: Orally bioavailable alkyl amines

Highly flexible ligand binding pocket of ecdysone receptor: a single amino acid change leads to discrimination between two groups of nonsteroidal ecdysone agonists

Synthesis and SAR of cis-1-Benzoyl-1,2,3,4-tetrahydroquinoline ligands for control of gene expression in ecdysone responsive systems

Optimization of α-acylaminoketone ecdysone agonists for control of gene expression

Synthesis and SAR of α-Acylaminoketone ligands for control of gene expression

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