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SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads

Clinical cancer research, 2018-12, Vol.24 (24), p.6570-6582

2018

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Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload

ACS medicinal chemistry letters, 2016-11, Vol.7 (11), p.983-987

2016

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Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumor Agents

Journal of medicinal chemistry, 2010-04, Vol.53 (7), p.2927-2941

2010

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Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation

Antibodies (Basel), 2017-11, Vol.6 (4), p.20

2017

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A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

Bioconjugate chemistry, 2013-07, Vol.24 (7), p.1256-1263

2013

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An Isomerization Approach to Tesirine and Pyrrolobenzodiazepines

Organic process research & development, 2019-11, Vol.23 (11), p.2543-2548

2019

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Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity

Molecular cancer therapeutics, 2023-02, Vol.22 (2), p.254-263

2023

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An Alternative Focus for Route Design for the Synthesis of Antibody–Drug Conjugate Payloads

Journal of organic chemistry, 2019-04, Vol.84 (8), p.4830-4836

2019

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Scale-up Synthesis of Tesirine

Organic process research & development, 2018-09, Vol.22 (9), p.1241-1256

2018

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Preclinical characterization of an antibody-drug conjugate targeting CS-1 and the identification of uncharacterized populations of CS-1-positive cells

Molecular cancer therapeutics, 2020-08, Vol.19 (8), p.1649-1659

2020

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Synthesis and in vitro evaluation of SG3227, a pyrrolobenzodiazepine dimer antibody-drug conjugate payload based on sibiromycin

Bioorganic & medicinal chemistry letters, 2017-03, Vol.27 (5), p.1154-1158

2017

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SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity

Cancer research (Chicago, Ill.), 2010-09, Vol.70 (17), p.6849-6858

2010

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Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1- c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (22), p.6463-6466

2009

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An asymmetric C8/C8′-tripyrrole-linked sequence-selective pyrrolo[2,1- c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs

Bioorganic & medicinal chemistry letters, 2008-03, Vol.18 (6), p.2073-2077

2008

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Application of the Stille coupling reaction to the synthesis of C2-substituted endo-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

Bioorganic & medicinal chemistry letters, 2004-10, Vol.14 (20), p.5041-5044

2004

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An optimised synthesis of SG3376, a non-cleavable antibody-drug conjugate pyrrolobenzodiazepine drug-linker

Tetrahedron letters, 2017-11, Vol.58 (46), p.4363-4366

2017

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SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer pro-drug that cross-links DNA and exerts highly potent antitumor activity

Cancer research (Chicago, Ill.), 2010-07, Vol.70 (17), p.6849-6858

2010

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Application of the Stille Coupling Reaction to the Synthesis of C2-Substituted endo-exo Unsaturated Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

ChemInform, 2005-01, Vol.36 (4), p.no-no

2005

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ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies

Blood, 2018-03, Vol.131 (10), p.1094-1105

2018

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ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Molecular cancer therapeutics, 2016-11, Vol.15 (11), p.2709-2721

2016

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Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates

Clinical cancer research, 2017-10, Vol.23 (19), p.5858-5868

2017

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A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis

PLoS neglected tropical diseases, 2019-05, Vol.13 (5), p.e0007373-e0007373

2019

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Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine−Poly(N-methylpyrrole) Conjugates

Journal of medicinal chemistry, 2006-09, Vol.49 (18), p.5442-5461

2006

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Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents

Chemical communications (Cambridge, England), 2002-08 (16), p.1764-1765

2002

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SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads

Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload

Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumor Agents

Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

An Isomerization Approach to Tesirine and Pyrrolobenzodiazepines

Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity

An Alternative Focus for Route Design for the Synthesis of Antibody–Drug Conjugate Payloads

Scale-up Synthesis of Tesirine

Preclinical characterization of an antibody-drug conjugate targeting CS-1 and the identification of uncharacterized populations of CS-1-positive cells

Synthesis and in vitro evaluation of SG3227, a pyrrolobenzodiazepine dimer antibody-drug conjugate payload based on sibiromycin

SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity

Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1- c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate

An asymmetric C8/C8′-tripyrrole-linked sequence-selective pyrrolo[2,1- c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs

Application of the Stille coupling reaction to the synthesis of C2-substituted endo-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

An optimised synthesis of SG3376, a non-cleavable antibody-drug conjugate pyrrolobenzodiazepine drug-linker

Comparison of pyrrolobenzodiazepine dimer bis-imine versus mono-imine: DNA interstrand cross-linking, cytotoxicity, and antibody-drug conjugate efficacy and toxicity

SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer pro-drug that cross-links DNA and exerts highly potent antitumor activity

Application of the Stille Coupling Reaction to the Synthesis of C2-Substituted endo-exo Unsaturated Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies

ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates

A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis

Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine−Poly(N-methylpyrrole) Conjugates

Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents

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