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Current Development Status of MEK Inhibitors

Molecules (Basel, Switzerland), 2017-09, Vol.22 (10), p.1551

2017

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Metal-Organic Framework (MOF)-Based Drug Delivery

Current medicinal chemistry, 2020-01, Vol.27 (35), p.5949

2020

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High-speed axial impact of aluminum honeycomb – Experiments and simulations

Composites. Part B, Engineering, 2014-01, Vol.56, p.1-8

2014

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Radioprotective effects and mechanism of HL-003 on radiation-induced salivary gland damage in mice

Scientific reports, 2022-05, Vol.12 (1), p.8419-8419, Article 8419

2022

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Polycysteine as a new type of radio-protector ameliorated tissue injury through inhibiting ferroptosis in mice

Cell death & disease, 2021-02, Vol.12 (2), p.195-16, Article 195

2021

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Current Developments in Pt(IV) Prodrugs Conjugated with Bioactive Ligands

Bioinorganic chemistry and applications, 2018-01, Vol.2018, p.8276139-18

2018

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Development of small-molecule immune checkpoint inhibitors of PD-1/PD-L1 as a new therapeutic strategy for tumour immunotherapy

Journal of drug targeting, 2019-03, Vol.27 (3), p.244-256

2019

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Preclinical characterization of tunlametinib, a novel, potent, and selective MEK inhibitor

Frontiers in pharmacology, 2023-09, Vol.14, p.1271268-1271268

2023

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Dynamic simulation of railway vehicle occupants under secondary impact

Vehicle system dynamics, 2013-12, Vol.51 (12), p.1803-1817

2013

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Phase I pharmacokinetic study of an oral, small-molecule MEK inhibitor tunlametinib in patients with advanced NRAS mutant melanoma

Frontiers in pharmacology, 2022-11, Vol.13, p.1039416-1039416

2022

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Development and engineering application of integrated safety monitoring systems for China's high-speed trains

Transportation safety and environment Online, 2024-04, Vol.6 (2)

2024

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Protective effects of new aryl sulfone derivatives against radiation-induced hematopoietic injury

Journal of radiation research, 2020-05, Vol.61 (3), p.388-398

2020

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N‐Heterocyclic Carbene‐Protected Ag Nanoparticles Immobilized on Polyacrylonitrile Fiber as Efficient Catalysts for a Three‐Component Coupling Reaction

Chemistry, an Asian journal, 2018-06, Vol.13 (12), p.1561-1569

2018

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Influencing Factors and Sensitivity Analysis of Occupant Impact Injury in Passenger Compartment

Traffic injury prevention, 2013-01, Vol.14 (8), p.816-822

2013

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New wind speed forecasting approaches using fast ensemble empirical model decomposition, genetic algorithm, Mind Evolutionary Algorithm and Artificial Neural Networks

Renewable energy, 2015-11, Vol.83, p.1066-1075

2015

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A New Compound with Increased Antitumor Activity by Cotargeting MEK and Pim-1

iScience, 2020-07, Vol.23 (7), p.101254-101254, Article 101254

2020

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Enantioselective Epoxidation of Terminal Olefins by Chiral Dioxirane

Organic letters, 2001-06, Vol.3 (12), p.1929-1931

2001

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Oral delivery of WR-1065 by ROS-responsive PEG-PCL nanoparticles for radioprotection

Colloids and surfaces. A, Physicochemical and engineering aspects, 2020-08, Vol.599, p.124886, Article 124886

2020

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Development of ERK1/2 inhibitors as a therapeutic strategy for tumour with MAPK upstream target mutations

Journal of drug targeting, 2020-02, Vol.28 (2), p.154-165

2020

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Experiments and parametric studies on 3D metallic auxetic metamaterials with tuneable mechanical properties

Smart materials and structures, 2015-09, Vol.24 (9), p.95016

2015

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Design and evaluation of pH-responsive hydrogel for oral delivery of amifostine and study on its radioprotective effects

Colloids and surfaces, B, Biointerfaces, 2020-11, Vol.195, p.111200-111200, Article 111200

2020

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A simple auxetic tubular structure with tuneable mechanical properties

Smart materials and structures, 2016-06, Vol.25 (6), p.65012-65020

2016

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Designing New Chiral Ketone Catalysts. Asymmetric Epoxidation of cis-Olefins and Terminal Olefins

Journal of organic chemistry, 2002-04, Vol.67 (8), p.2435-2446

2002

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1,4-Dithiothreitol treatment ameliorates hematopoietic and intestinal injury in irradiated mice: Potential application of a treatment for acute radiation syndrome

International immunopharmacology, 2019-11, Vol.76, p.105913, Article 105913

2019

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Neuroprotective Effect of a New Free Radical Scavenger HL-008 in an Ischemia–Reperfusion Injury Rat Model

Neuroscience, 2021-06, Vol.465, p.105-115

2021

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Current Development Status of MEK Inhibitors

Metal-Organic Framework (MOF)-Based Drug Delivery

High-speed axial impact of aluminum honeycomb – Experiments and simulations

Radioprotective effects and mechanism of HL-003 on radiation-induced salivary gland damage in mice

Polycysteine as a new type of radio-protector ameliorated tissue injury through inhibiting ferroptosis in mice

Current Developments in Pt(IV) Prodrugs Conjugated with Bioactive Ligands

Development of small-molecule immune checkpoint inhibitors of PD-1/PD-L1 as a new therapeutic strategy for tumour immunotherapy

Preclinical characterization of tunlametinib, a novel, potent, and selective MEK inhibitor

Dynamic simulation of railway vehicle occupants under secondary impact

Phase I pharmacokinetic study of an oral, small-molecule MEK inhibitor tunlametinib in patients with advanced NRAS mutant melanoma

Development and engineering application of integrated safety monitoring systems for China's high-speed trains

Protective effects of new aryl sulfone derivatives against radiation-induced hematopoietic injury

N‐Heterocyclic Carbene‐Protected Ag Nanoparticles Immobilized on Polyacrylonitrile Fiber as Efficient Catalysts for a Three‐Component Coupling Reaction

Influencing Factors and Sensitivity Analysis of Occupant Impact Injury in Passenger Compartment

New wind speed forecasting approaches using fast ensemble empirical model decomposition, genetic algorithm, Mind Evolutionary Algorithm and Artificial Neural Networks

A New Compound with Increased Antitumor Activity by Cotargeting MEK and Pim-1

Enantioselective Epoxidation of Terminal Olefins by Chiral Dioxirane

Oral delivery of WR-1065 by ROS-responsive PEG-PCL nanoparticles for radioprotection

Development of ERK1/2 inhibitors as a therapeutic strategy for tumour with MAPK upstream target mutations

Experiments and parametric studies on 3D metallic auxetic metamaterials with tuneable mechanical properties

Design and evaluation of pH-responsive hydrogel for oral delivery of amifostine and study on its radioprotective effects

A simple auxetic tubular structure with tuneable mechanical properties

Designing New Chiral Ketone Catalysts. Asymmetric Epoxidation of cis-Olefins and Terminal Olefins

1,4-Dithiothreitol treatment ameliorates hematopoietic and intestinal injury in irradiated mice: Potential application of a treatment for acute radiation syndrome

Neuroprotective Effect of a New Free Radical Scavenger HL-008 in an Ischemia–Reperfusion Injury Rat Model

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