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A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice

Science translational medicine, 2012-11, Vol.4 (159), p.159ra147

2012

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TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury

American journal of physiology. Lung cellular and molecular physiology, 2014-07, Vol.307 (2), p.L158-L172

2014

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N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I

The Journal of pharmacology and experimental therapeutics, 2008-08, Vol.326 (2), p.432-442

2008

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Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4

ACS medicinal chemistry letters, 2017-05, Vol.8 (5), p.549-554

2017

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Overactive Bladder and Incontinence in the Absence of the BK Large Conductance Ca2+-activated K+ Channel

The Journal of biological chemistry, 2004-08, Vol.279 (35), p.36746-36752

2004

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Enhanced sensitivity to afferent stimulation and impact of overactive bladder therapies in the conscious, spontaneously hypertensive rat

The Journal of pharmacology and experimental therapeutics, 2011-07, Vol.338 (1), p.392-399

2011

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Ion channels in smooth muscle: regulators of intracellular calcium and contractility

Canadian journal of physiology and pharmacology, 2005-03, Vol.83 (3), p.215-242

2005

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The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans

EJNMMI research, 2019-05, Vol.9 (1), p.45-12, Article 45

2019

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Enhanced bladder capacity and reduced prostaglandin E2-mediated bladder hyperactivity in EP3 receptor knockout mice

American journal of physiology. Renal physiology, 2008-08, Vol.295 (2), p.F507

2008

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Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current

The Journal of physiology, 2003-05, Vol.549 (1), p.65-74

2003

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Functional TRPV4 channels and an absence of capsaicin-evoked currents in freshly-isolated, guinea-pig urothelial cells

Channels (Austin, Tex.), 2009-05, Vol.3 (3), p.156-160

2009

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PROPERTIES OF THE TRPV4 AGONIST GSK1016790A AND the TRPV4 ANTAGONIST GSK2193874

Physiological reviews, 2017-10, Vol.97 (4), p.1231-1232

2017

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Development of Focal Segmental Glomerulosclerosis Patient-Reported Outcome Measures: Symptom Diary and Symptom Impact Questionnaire

American journal of kidney diseases, 2017-10, Vol.70 (4), p.532-540

2017

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Properties of a tonically active, sodium-permeable current in mouse urinary bladder smooth muscle

American Journal of Physiology: Cell Physiology, 2004-06, Vol.286 (6), p.C1246-C1257

2004

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Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo

The Journal of pharmacology and experimental therapeutics, 2021-03, Vol.376 (3), p.436-443

2021

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Heteromultimeric Kv1.2-Kv1.5 Channels Underlie 4-Aminopyridine-Sensitive Delayed Rectifier K+ Current of Rabbit Vascular Myocytes

Circulation research, 2001-11, Vol.89 (11), p.1038-1044

2001

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Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4)

ACS medicinal chemistry letters, 2019-08, Vol.10 (8), p.1228-1233

2019

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Protein kinase C modulation of recombinant ATP-sensitive K+ channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B

The Journal of physiology, 2002-05, Vol.541 (1), p.65-80

2002

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Predictive Value of Delayed Graft Function Definitions Following Donation After Circulatory Death Renal Transplantation in the United Kingdom

Transplant research and risk management, 2022-06, Vol.14, p.21-33

2022

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The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction

Neuroscience letters, 2009-03, Vol.452 (1), p.28-32

2009

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Assessing the Impact of Losmapimod on Proteinuria in Idiopathic Focal Segmental Glomerulosclerosis

Kidney international reports, 2020-08, Vol.5 (8), p.1228-1239

2020

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Voltage-gated Na+ Channel Blockers Reduce Functional Bladder Capacity in the Conscious Spontaneously Hypertensive Rat

Urology (Ridgewood, N.J.), 2012-06, Vol.79 (6), p.1410.e1-1410.e6

2012

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Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema

ACS medicinal chemistry letters, 2013-02, Vol.4 (2), p.293-296

2013

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A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice

TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury

An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure

Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4

Overactive Bladder and Incontinence in the Absence of the BK Large Conductance Ca2+-activated K+ Channel

Enhanced sensitivity to afferent stimulation and impact of overactive bladder therapies in the conscious, spontaneously hypertensive rat

Ion channels in smooth muscle: regulators of intracellular calcium and contractility

The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans

Enhanced bladder capacity and reduced prostaglandin E2-mediated bladder hyperactivity in EP3 receptor knockout mice

Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current

Functional TRPV4 channels and an absence of capsaicin-evoked currents in freshly-isolated, guinea-pig urothelial cells

PROPERTIES OF THE TRPV4 AGONIST GSK1016790A AND the TRPV4 ANTAGONIST GSK2193874

Development of Focal Segmental Glomerulosclerosis Patient-Reported Outcome Measures: Symptom Diary and Symptom Impact Questionnaire

Properties of a tonically active, sodium-permeable current in mouse urinary bladder smooth muscle

Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo

Heteromultimeric Kv1.2-Kv1.5 Channels Underlie 4-Aminopyridine-Sensitive Delayed Rectifier K+ Current of Rabbit Vascular Myocytes

Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4)

Protein kinase C modulation of recombinant ATP-sensitive K+ channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B

Mortality and adverse events of special interest with intravenous belimumab for adults with active, autoantibody-positive systemic lupus erythematosus (BASE): a multicentre, double-blind, randomised, placebo-controlled, phase 4 trial

Predictive Value of Delayed Graft Function Definitions Following Donation After Circulatory Death Renal Transplantation in the United Kingdom

The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction

Assessing the Impact of Losmapimod on Proteinuria in Idiopathic Focal Segmental Glomerulosclerosis

Voltage-gated Na+ Channel Blockers Reduce Functional Bladder Capacity in the Conscious Spontaneously Hypertensive Rat

Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema

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