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High Systolic Blood Pressure Induces Cerebral Microvascular Endothelial Dysfunction, Neurovascular Unit Damage, and Cognitive Decline in Mice

Hypertension (Dallas, Tex. 1979), 2019-01, Vol.73 (1), p.217-228

2019

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Hypertension accelerates cerebral tissue PO2 disruption in Alzheimer’s disease

Neuroscience letters, 2020-01, Vol.715, p.134626, Article 134626

2020

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Voluntary exercise increases brain tissue oxygenation and spatially homogenizes oxygen delivery in a mouse model of Alzheimer's disease

Neurobiology of aging, 2020-04, Vol.88, p.11-23

2020

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Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Aging (Albany, NY.), 2019-06, Vol.11 (11), p.3832-3850

2019

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Non-Alcoholic Fatty Liver Disease, and the Underlying Altered Fatty Acid Metabolism, Reveals Brain Hypoperfusion and Contributes to the Cognitive Decline in APP/PS1 Mice

Metabolites, 2019-05, Vol.9 (5), p.104

2019

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A Pilot Study Investigating Changes in Capillary Hemodynamics and Its Modulation by Exercise in the APP-PS1 Alzheimer Mouse Model

Frontiers in neuroscience, 2019-12, Vol.13, p.1261-1261

2019

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The impact of high‐intensity interval training on ventricular remodeling in patients with a recent acute myocardial infarction—A randomized training intervention pilot study

Clinical cardiology (Mahwah, N.J.), 2019-12, Vol.42 (12), p.1222-1231

2019

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Systolic hypertension-induced neurovascular unit disruption magnifies vascular cognitive impairment in middle-age atherosclerotic LDLr−/−:hApoB+/+ mice

GeroScience, 2019-10, Vol.41 (5), p.511-532

2019

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NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse

Cardiovascular research, 2010-01, Vol.85 (1), p.204-213

2010

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Angiopoietin-like 2 is essential to aortic valve development in mice

Communications biology, 2022-11, Vol.5 (1), p.1277-1277, Article 1277

2022

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Angiotensin II Type I and Prostaglandin F2α Receptors Cooperatively Modulate Signaling in Vascular Smooth Muscle Cells

The Journal of biological chemistry, 2015-01, Vol.290 (5), p.3137-3148

2015

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Impact of pulse pressure on cerebrovascular events leading to age-related cognitive decline

American journal of physiology. Heart and circulatory physiology, 2018-06, Vol.314 (6), p.H1214-H1224

2018

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The role of cellular senescence in cardiac disease: basic biology and clinical relevance

Nature reviews cardiology, 2022-04, Vol.19 (4), p.250

2022

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Knockdown of angiopoietin-like 2 mimics the benefits of intermittent fasting on insulin responsiveness and weight loss

Experimental biology and medicine (Maywood, N.J.), 2018-01, Vol.243 (1), p.45-49

2018

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Endothelium-dependent control of cerebrovascular functions through age: exercise for healthy cerebrovascular aging

American journal of physiology. Heart and circulatory physiology, 2013-09, Vol.305 (5), p.H620-H633

2013

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A single Mediterranean meal does not impair postprandial flow-mediated dilatation in healthy men with subclinical metabolic dysregulations

Applied physiology, nutrition, and metabolism, 2016-08, Vol.41 (8), p.888

2016

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Lack of Angiopoietin‐Like‐2 Expression Limits the Metabolic Stress Induced by a High‐Fat Diet and Maintains Endothelial Function in Mice

Journal of the American Heart Association, 2014-08, Vol.3 (4), p.n/a

2014

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Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence

International journal of molecular sciences, 2021-11, Vol.22 (22), p.12232

2021

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Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Frontiers in cardiovascular medicine, 2021-03, Vol.8, p.658400-658400

2021

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Pulse pressure-dependent cerebrovascular eNOS regulation in mice

Journal of cerebral blood flow and metabolism, 2017-02, Vol.37 (2), p.413-424

2017

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Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation

PloS one, 2019-08, Vol.14 (8), p.e0221547-e0221547

2019

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Epigenetic Regulatory Effect of Exercise on Glutathione Peroxidase 1 Expression in the Skeletal Muscle of Severely Dyslipidemic Mice

PloS one, 2016-03, Vol.11 (3), p.e0151526-e0151526

2016

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Vascular Disease Risk in Patients With Hypertriglyceridemia: Endothelial Progenitor Cells, Oxidative Stress, Accelerated Senescence, and Impaired Vascular Repair

Canadian journal of cardiology, 2011-09, Vol.27 (5), p.538-540

Thorin, Eric, PhD

2011

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Knockdown of ANGPTL2 promotes left ventricular systolic dysfunction by upregulation of NOX4 in mice

Frontiers in physiology, 2024-02, Vol.15, p.1320065-1320065

2024

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High Systolic Blood Pressure Induces Cerebral Microvascular Endothelial Dysfunction, Neurovascular Unit Damage, and Cognitive Decline in Mice

Hypertension accelerates cerebral tissue PO2 disruption in Alzheimer’s disease

Voluntary exercise increases brain tissue oxygenation and spatially homogenizes oxygen delivery in a mouse model of Alzheimer's disease

Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Non-Alcoholic Fatty Liver Disease, and the Underlying Altered Fatty Acid Metabolism, Reveals Brain Hypoperfusion and Contributes to the Cognitive Decline in APP/PS1 Mice

A Pilot Study Investigating Changes in Capillary Hemodynamics and Its Modulation by Exercise in the APP-PS1 Alzheimer Mouse Model

The impact of high‐intensity interval training on ventricular remodeling in patients with a recent acute myocardial infarction—A randomized training intervention pilot study

Systolic hypertension-induced neurovascular unit disruption magnifies vascular cognitive impairment in middle-age atherosclerotic LDLr−/−:hApoB+/+ mice

ADCY9 (Adenylate Cyclase Type 9) Inactivation Protects From Atherosclerosis Only in the Absence of CETP (Cholesteryl Ester Transfer Protein)

NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse

Angiopoietin-like 2 is essential to aortic valve development in mice

Angiotensin II Type I and Prostaglandin F2α Receptors Cooperatively Modulate Signaling in Vascular Smooth Muscle Cells

Impact of pulse pressure on cerebrovascular events leading to age-related cognitive decline

The role of cellular senescence in cardiac disease: basic biology and clinical relevance

Knockdown of angiopoietin-like 2 mimics the benefits of intermittent fasting on insulin responsiveness and weight loss

Endothelium-dependent control of cerebrovascular functions through age: exercise for healthy cerebrovascular aging

A single Mediterranean meal does not impair postprandial flow-mediated dilatation in healthy men with subclinical metabolic dysregulations

Lack of Angiopoietin‐Like‐2 Expression Limits the Metabolic Stress Induced by a High‐Fat Diet and Maintains Endothelial Function in Mice

Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Pulse pressure-dependent cerebrovascular eNOS regulation in mice

Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation

Epigenetic Regulatory Effect of Exercise on Glutathione Peroxidase 1 Expression in the Skeletal Muscle of Severely Dyslipidemic Mice

Vascular Disease Risk in Patients With Hypertriglyceridemia: Endothelial Progenitor Cells, Oxidative Stress, Accelerated Senescence, and Impaired Vascular Repair

Knockdown of ANGPTL2 promotes left ventricular systolic dysfunction by upregulation of NOX4 in mice

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